Vol 64, No 4 (1983)

Experimental substantiation of the introduction of new chemical compounds into clinical practice


The actual problems of pharmacology are the search for biologically active substances and the study of the mechanism of their action. Kazan pharmacologists have been engaged in experimental research of new chemical compounds from various chemical classes for more than 25 years. These searches are conducted on the basis of scientific observation of the relationship between chemical structure and pharmacological activity and pursue the goal of practical use of the most biologically active substances as medicines.

Kazan medical journal. 1983;64(4):241-246
pages 241-246 views

Clinical medicine

Clinical significance of the determination of peripheral t- and vlymphocytes in viral hepatitis a in children

Bashirova D.K., Zakirov I.G.


A number of authors have shown that viral hepatitis suppresses cellular immunity, depending on the severity of the disease [1-4]. However, the influence of various factors on the immune response in viral hepatitis A (HCV) remains poorly understood.

Kazan medical journal. 1983;64(4):246-248
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Circulating immune complexes in jaundice

Samerkhanova L.C., Enaleeva D.S., Mayansky A.N.


In recent years, intensive research has been conducted to detect immune complexes (IC) in viral hepatitis [6]. ICS are determined in the acute phase of viral hepatitis B [4, 5] and A [2, 3]. In the literature available to us, we have not found works on the detection of IR in jaundice of a non-viral nature, therefore, the purpose of this study was to study the content of circulating IR in jaundice of various genesis.

Kazan medical journal. 1983;64(4):248-251
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Clinical significance of the study of the platelet link of hemostasis in viral hepatitis

Sorinson S.N., Kozulin V.E.


The decisive importance in the pathogenesis of hemostasis disorders in viral hepatitis is mainly attributed to a decrease in the content of plasma coagulation factors. The development of an extensive cytolytic process in the liver explains the violation of the synthesis of prothrombin, proaccelerin, proconvertin, partially fibrinogen, a disorder of the regulation of fibrinolysis [1, 4]. Changes in the platelet link of hemostasis in viral hepatitis are completely insufficiently covered in the literature [5, 10]. At the same time, it is known that at the initial stages of hemostasis disorders, it is the platelet link that plays the leading role. This is due to angiotrophic (maintaining the normal state of microvascular walls), adhesive-aggregation (the property of forming a primary platelet plug), concentration-transport (adsorption of many coagulation factors) functions, the ability to maintain microvascular spasm and inhibitory effect on fibrinolysis [2].

Kazan medical journal. 1983;64(4):251-254
pages 251-254 views

Clinic and treatment of viral hepatitis b in children

Faerman N.N., Oleinik M.D., Shilenok A.I., Ryabikova T.F., Pavlova T.V., Nosenko N.V., Kivatovsky M.V., Zhivnina L.A., Kalyagina L.S.


Despite the large number of works devoted to the study of viral hepatitis B (HBV) in children, the issues of the clinic, diagnosis and treatment of this infection have not yet been fully resolved. The frequency of HBV among children hospitalized in the hepatitis department is 12.2% [7].

Kazan medical journal. 1983;64(4):254-258
pages 254-258 views

Glucocorticosteroid therapy for viral hepatitis in children

Shilenok A.I., Pavlova T.V., Krasnov V.V., Zhivotovsky M.V., Zhivnina L.A.


Despite the large number of works devoted to the treatment of children with viral hepatitis (VH), this issue has not yet been fully resolved. A number of authors recommend the use of glucocorticosteroids along with basic therapy [1, 6, 7]. The basis for their appointment is their characteristic anti-inflammatory, anti-allergic effect, the ability to stabilize cell membranes and stimulate the protein-synthetic function of the liver [7], positively affect fat metabolism [9] and the state of the liver RES [8], normalize redox processes [3].

Kazan medical journal. 1983;64(4):258-260
pages 258-260 views

Differential diagnosis of viral hepatitis and mechanical jaundice on the basis of neoplasms

Fatkulov M.S.


Correct and timely differential diagnosis of viral hepatitis from mechanical jaundice, especially on the basis of neoplasms, is still an urgent problem.

Kazan medical journal. 1983;64(4):260-262
pages 260-262 views

Liver damage in rheumatism

Starkova N.V.


In some cases, the rheumatic process goes into the stage of autoaggression. At the same time, there is a lesion not only of the heart and visceral membranes, but also of the liver and other organs. In order to detect autoaggressive liver damage in rheumatism, we established a reaction of inhibition of leukocyte migration (RTML) using purified liver tissue antigens [1]. The dilution of the antigen with a protein content of 10 micrograms in 1 ml was used.

Kazan medical journal. 1983;64(4):262-263
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Diagnosis and treatment of diffuse liver lesions in mechanical jaundice

Kuznetsov V.A., Kharin G.M., Georgikia R.K., Kharitonov G.I.


The frequency of involvement of the liver in the pathological process, accompanied by significant changes in the resistance of the body, and the unsatisfactory results of the treatment currently lead to an intensified search for new methods and means for the diagnosis and correction of lesions of the hepatoportal system in mechanical jaundice. The complex of changes developing in the liver with extrahepatic cholestasis and manifested in a combination of dystrophic, inflammatory, necrotic and sclerotic processes is well known. At the same time, in this type of pathology, in recent years, violations of immunological regulation have been increasingly noted, often underlying the development of structural and functional liver lesions [5, 6]. However, until now, in clinical practice, mainly biochemical blood tests with very relative reliability are used to assess the degree of involvement of the liver in the pathological process. In particular, we have previously shown that when comparing the functional and morphological indicators of the liver condition in patients with chronic calculous cholecystitis and its complications, a discrepancy between the data of biochemical blood tests and the severity of diffuse organ damage is found in 64%. There are no corresponding functional criteria for altered histophysiological parameters of the liver [2]. In this regard, a detailed comparative analysis of morphological, biochemical, immunological and clinical data obtained in pre and postoperative periods in patients with mechanical jaundice is theoretically and practically justified.

Kazan medical journal. 1983;64(4):263-266
pages 263-266 views

Express diagnostics of acute liver and biliary tract diseases with jaundice syndrome in emergency surgery

Salikhov I.A., Voronin V.N., Zolkin N.N.


The relevance of the diagnosis and differentiation of acute liver and biliary tract diseases with other diseases accompanied by jaundice is beyond doubt. This problem is of particular importance in the practice of emergency abdominal surgery when patients with jaundice are admitted to a hospital providing urgent care. The difficulty of establishing the type of jaundice and their prognosis is well known. It is due to both the severity of the patients' condition and the presence of contraindications to complex diagnostic studies.

Kazan medical journal. 1983;64(4):267-269
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Histamine dynamics in acute respiratory viral diseases in children

Tsaregorodtsev A.D., Tukhvatullina R.R., Anokhin V.A.


Blood mediators, including histamine, play an essential role in the pathogenesis of acute respiratory diseases (ARI) in children [3].

Kazan medical journal. 1983;64(4):267-271
pages 267-271 views

Escherichiosis in adult patients

Gelfand L.L.


Intestinal infections caused by enteropathogenic Escherichia coli (ESCH) have long been considered primarily a childhood infection. However, in recent years, cases of escherichiosis among adults have become more frequent.

Kazan medical journal. 1983;64(4):272-273
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X-ray diagnostics of lumbar osteochondrosis and its consequences

Kamalov I.I.


The purpose of this work was to identify the radiological features of lumbar osteochondrosis and its consequences - herniated discs.

Kazan medical journal. 1983;64(4):273-275
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Vertebrogenic ilio-lumbar syndrome (Ilio-lumbar muscle syndrome)

Popelyansky A.Y., Khabirov F.A.


It has been established that pathological tension of the lumbosacral muscle constantly accompanies violations of the function of the thoracic spine due to organic diseases of the internal organs with lumbalgia, coccalgia and coccygodynia [3], as well as in connection with orthostatic ilio-lumbar spasm [2]. However, the clinical features and pathogenesis of this syndrome remain insufficiently studied. The iliopsoas muscle is formed from the junction of the large lumbar (ch. psoas major) and iliac (m. iliacus) muscles. The large lumbar muscle is located on the posterior abdominal wall on the sides of the spine. It originates from the transverse processes of all lumbar vertebrae, from the lateral surface of the bodies of the last thoracic and all lumbar vertebrae and from the lateral surface of the intervertebral discs of the corresponding vertebrae. To understand the function of the muscle, it is important to take into account that in its upper parts it begins from the posterior surfaces of the vertebral bodies, with the reduction of these parts of it, lumbar lordosis increases. The reduction of the bulk of the bundles attached to the anterior and lateral surfaces of the vertebral bodies provides kyphosis [1].

Kazan medical journal. 1983;64(4):275-279
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Remission clinic in patients with lumbar osteochondrosis

Veselovsky V.P., Naumova N.V.


Lumbar osteochondrosis — one of the most common chronic human diseases - is the cause of temporary disability from 12 to 14% of all workers of large industrial enterprises. In this regard, the reduction of morbidity due to lumbar osteochondrosis is an important economic problem. The most promising in this regard are preventive measures, which, however, cannot be carried out without taking into account the clinical features of the disease in remission. There is no complete description of this pathology in the literature during the so-called cold period. A number of authors believe that the symptoms of the disease do not appear during remission [2]. At the same time, it is known that osteochondrosis of the spine has a chronic course, therefore, the process continues both during the period of exacerbation and during remission. The objective of this study was to identify the clinical features of lumbar osteochondrosis during remission.

Kazan medical journal. 1983;64(4):279-281
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Standards of rheoencephalogram of children

Khaibullina F.G.


It is generally recognized that one of the adequate methods for assessing the state of cerebral hemodynamics is rheoencephalography, which has found wide application in general neurology. In relation to children, the rheoencephalographic assessment of cerebral blood flow has been studied completely insufficiently, and even with severe cerebral vascular disorders, according to REG data, it is difficult to draw serious conclusions, since there are no unified ideas about normal rheoencephalographic parameters in childhood. Isolated publications on this topic contain contradictory information [1, 4, 5].

Kazan medical journal. 1983;64(4):282-283
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Intracranial hypertension in cerebral autonomic disorders in children

Ismagilov M.F., Khasanova D.R., Ainulov D.S.


Common generalized forms of autonomic disorders of cerebral genesis in children and adolescents are described as vegetative vascular dystonia syndrome [2, 4]. Analysis of the clinical picture and course of these disorders suggests that hypertension-hydrocephalus syndrome plays a significant role in their formation. What are its clinical manifestations, to what extent are these signs expressed, by what means and techniques can they be established in outpatient and inpatient settings? To solve these issues, we analyzed the fundus picture, the results of X-ray examination of the skull and echoencephalography in 156 children aged 8 to 15 years.

Kazan medical journal. 1983;64(4):283-286
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The effect of natal injuries of the cervical spine on the development of myopia in children

Ratner A.Y., Berezina T.G., Ratush A.M.


We found a relationship between natal damage to the cervical spine, vertebral arteries and the development of myopia in children. In the process of rehabilitation treatment of patients with mild upper paraparesis and other manifestations of natal cervical inferiority, we were faced with the fact that in some of these children, who also had myopia, the severity of visual disturbances after neurological treatment became significantly weaker. This prompted us to conduct a special set of targeted studies and try to comprehend the findings.

Kazan medical journal. 1983;64(4):286-288
pages 286-288 views

Experience of coping with severe alcohol withdrawal

Kovalenko V.P.


The issues of treatment of alcoholic psychoses are currently being successfully solved using forced diuresis, infusion therapy, various narcotic drugs, hemodialysis using an artificial kidney device and detoxification hemosorption. The relief of severe alcohol withdrawal should resemble, in our opinion, the treatment of alcoholic psychoses, which requires the organization of intensive care wards in ordinary drug treatment hospitals.

Kazan medical journal. 1983;64(4):288-290
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Clinical evaluation of long-term remissions in alcoholism

Shaidukova L.K.


We studied 418 remissions lasting 2-7 years in 110 men (average age — 45 years) with chronic alcoholism. 78 people were in remission for 2-5 years, the remaining 32 abstained from 5 to 7 years.

Kazan medical journal. 1983;64(4):290-292
pages 290-292 views

Collagen metabolites in gastric and duodenal ulcer

Panfilov Y.A., Kochetkov S.G.


The introduction of a fiber-optic endoscope into clinical practice has created optimal conditions for dynamic examination and evaluation of the effectiveness of the treatment of patients with gastric and duodenal ulcer. However, gastroscopic examination is a complex instrumental method. During gastroscopy, in 0.04—0.1% of cases, such formidable complications as perforations and cracks of the esophagus and stomach may develop [2].

Kazan medical journal. 1983;64(4):292-293
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Dynamics of gastrin level in the blood during surgical treatment of duodenal ulcer

Maltchikov A.Y.


Recently, the attention of clinicians has been drawn to deciphering the role of gastrin in the pathogenesis of peptic ulcer disease. Literature data on the content of gastrin in the blood of patients with duodenal ulcer are very contradictory. In most studies, the level of gastrin was studied depending on the age of the patients, the location of the ulcer, and the phase of activity. Information about the dynamics of gastrin in blood serum after surgical treatment is presented in single publications [1, 2, 5].

Kazan medical journal. 1983;64(4):293-295
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Continuous removable monofilament suture of the abdominal wall with lateral appendicular accesses

Kochnev O.S., Gainullin U.S.


Большинство хирургов считают, что наилучшим при аппендэктомии является разрез брюшной стенки по Волковичу—Дьяконову (Мак-Бернею), и незаслуженно игнорируют поперечный доступ [3].

Kazan medical journal. 1983;64(4):295-298
pages 295-298 views

Surgical treatment of cholecystitis

Lysenko V.A., Sitnikov V.A., Ivanenkov A.A., Pushkarev V.P., Ivanov A.M., Bryndin V.V.


According to domestic and foreign authors, the frequency of gallbladder diseases and surgical interventions for cholecystitis has increased markedly in recent years. Acute cholecystitis currently occupies the second place in urgent abdominal surgery after appendicitis, and in elderly and senile people it is more common. Despite the increase in the number of patients hospitalized as planned for surgical treatment from Therapeutic departments, the majority of patients continue to be admitted urgently with various diagnoses — with acute cholecystitis, exacerbation of chronic cholecystitis, acute hematocholecystitis, cholecystopancreatitis and others. Surgeons are faced with the task of understanding this variety of diagnoses, establishing the true cause of suffering and choosing the most rational treatment tactics. For many years, surgeons have adhered to conservative and wait-and-see tactics in acute cholecystitis. Attempts to activate surgical treatment of acute cholecystitis, equate it with tactics for acute appendicitis led to high postoperative mortality (10-20%) and unsatisfactory long-term results [1-3]. This forced most surgeons to refuse to perform operations at the height of an attack of acute cholecystitis, to consider only the picture of peritonitis as an indication for an emergency operation.

Kazan medical journal. 1983;64(4):298-230
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Lithium carbonate and mercazolil in preoperative preparation of patients with toxic goiter

Slobozhanin M.I.


One of the important problems in thyroid surgery for toxic forms of goiter is preoperative preparation, the main purpose of which is to achieve the euthyroid state. Only under this condition, the risk of exacerbation of thyrotoxicosis in the postoperative period is excluded.

Kazan medical journal. 1983;64(4):300-302
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Clinical experiences

Clinical and immunological parallels in intestinal coliinfection in children of the first year of life

Lavrentiev G.P., Tseka Y.S.


The study of cellular and humoral immunity in intestinal coliinfection in children of the first year of life, depending on the characteristics of the clinical course of the disease. For this purpose, the absolute content of T-, B-, D-lymphocytes and immunoglobulins G, M, and in the blood of 71 patients with intestinal coliinfection under the age of 1 year was determined, 55 of them had a moderate disease, 16 had a severe form, which was observed in children of the first six months.

Kazan medical journal. 1983;64(4):302-302
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Energy metabolism and its correction in patients with food toxicoinfections

Tselik N.I.


The content of adenyl nucleotides and deformability of peripheral blood erythrocytes were studied in patients with food toxicoinfections (PTI). 92 patients aged 16 to 55 years were examined, of which 34 had severe disease and 58 had moderate. Salmonella etiology of PTI was confirmed in 55 individuals in the laboratory. The patients were treated with solutions of "Kvartasol" (intravenously) and "Oratil" (orally). Blood for the study was obtained from the cubital vein before treatment, 2 and 24 hours after infusion and 5-7 days after treatment. The content of 2,3-DPH, ATP, ADP and AMP in erythrocytes was determined; the sum of nucleotides and the relative concentration of ATP were calculated. The deformability of erythrocytes was judged by the filterability index, using Synpor-1 filters. The control group consisted of 20 practically healthy individuals (the results are presented in the table).

Kazan medical journal. 1983;64(4):302-304
pages 302-304 views

About pathogenetic therapy of food toxicoinfections of salmonella etiology

Turyanov M.X.


From 1977 to 1980, 324 patients with food toxicoinfections were under our supervision, 148 of them had coprocultures of various groups of salmonella isolated. Food toxicoinfection of moderate severity was noted in 267 patients, severe — in 57.

Kazan medical journal. 1983;64(4):304-305
pages 304-305 views

Duration of labor activity in different age groups

Baiterek I.K., Yarullin A.X.


According to current opinion , childbirth in primiparous women lasts on average 18-20 hours . However, at present, new information has appeared in the literature, according to which their duration in most cases is 11-12 hours. There is also evidence that during childbirth for more than 16 hours, the cerebral hemodynamics of the fetus and newborn are disrupted and significant changes in the metabolic processes of the child are noted.

Kazan medical journal. 1983;64(4):305-305
pages 305-305 views

Closed craniocerebral injury

Nikolaev G.M., Khabibrakhmanov R.M.


From 1970 to 1980, 14,099 patients were admitted to the neurosurgery department of the 15th City Hospital in Kazan, of which 4,358 (30.9%) people were operated on for injuries. We conducted a survey of the victims in 1979. In total, 1,442 people with traumatic brain injury were hospitalized during the year, 748 of them (51.9%) with concussion,' 182 (12,6%)--- with a brain contusion, not complicated by intracranial hemorrhage. As can be seen, concussions and bruises of the brain prevail, amounting to 64.5%. Of the above-mentioned contingent of victims, only one patient died, who had a brain contusion (clinical diagnosis) on the background of a fracture of the cranial vault and the base of the brain at the autopsy.

Kazan medical journal. 1983;64(4):305-306
pages 305-306 views

Surgical treatment of complications after suturing of a perforated ulcer of the stomach and duodenum

Yakovlev A.Y., Smirnov A.G.


It is known that in a certain part of patients who have undergone suturing of perforated ulcers of the stomach and duodenum, complications subsequently arise in which repeated surgery becomes inevitable. Usually, resection of the organ is performed, which is associated with known difficulties due to the adhesive process and pronounced scarring changes.

Kazan medical journal. 1983;64(4):306-307
pages 306-307 views

Giant false pancreatic cyst

Krasilnikov D.M., Yunusov R.V.


Due to the increased frequency of pancreatic pseudocysts, it is of great practical importance to study the issues of diagnosis, choice of volume and method of surgical intervention in this pathology. Here is our observation.

Kazan medical journal. 1983;64(4):307-308
pages 307-308 views

Absorption function of macrophages in patients with syringomyelia

Zarudi Z.X.


We studied nonspecific reactivity in patients with syringomyelia. To determine the absorption capacity of macrophages, a method was used to study the phagocytic function of the reticuloendothelial system (RES) using a colloidal 198 Au.

Kazan medical journal. 1983;64(4):308-308
pages 308-308 views

The effect of dimethyl sulfoxide and glycerin on the activity of tissue thromboplastin

Baykeev R.F.


In the present study, the effect of glycerin and dimethyl sulfoxide (DMSO) cryoprotectors on the thromboplastic activity of myelin and tissue thromboplastin manufactured by the Kaunas Enterprise of Human Brain Preparations was studied. The appearance of a tissue thromboplastin in the bloodstream causes thrombosis or thrombohemorrhagic syndrome, characteristic of a large number of surgical, obstetric, therapeutic, infectious and other diseases.[1]

Kazan medical journal. 1983;64(4):308-309
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Results of dynamic examination of acute and chronic HBsAg carriers

Podlevsky A.F., Maslov V.P.


188 former donors, carriers of the Australian antigen (HBsAg) of young and middle age, who do not have concomitant diseases, were under observation. In accordance with the recommendations of the WHO scientific group, 80 people were classified as acute and 79 as chronic carriers. Of these, 3/4 were men and ¼ were women. All of them were subjected to a thorough clinical and laboratory examination, with 154 people both on an outpatient basis and in the clinic, and 34 - only on an outpatient basis. After the initial examination, all of them were taken on dispensary registration and were under supervision from one year to 3.5 years, undergoing examination in the 1st quarter monthly, and subsequently at least once every six months.

Kazan medical journal. 1983;64(4):309-310
pages 309-310 views



Mindubaeva Ф.Z., Tukhvatullina L.M.


The causes of disorders of menstrual and reproductive functions of women are mainly disorders of the hypothalamic-pituitary system, adrenal cortex, ovaries. With the central genesis of the disease, endocraniosis is often detected in various manifestations [2-4,86].

Kazan medical journal. 1983;64(4):310-312
pages 310-312 views

Social hygiene and healthcare management

A simplified version of the calculation of the annual dynamics of morbidity in viral hepatitis

Trifonov V.A., Oleinik M.D., Vasilyeva L.A., Shamsutdinov F.S.


Statistical analysis of the annual dynamics of morbidity makes it possible to quantify three forms of manifestation of the epidemic process: 1) year-round morbidity; 2) seasonal, "premium", 3) outbreak morbidity [4]. The obtained results can be used for separate planning of anti-epidemic measures for the purpose of operational observation and short-term forecasting [1, 2a, b].

Kazan medical journal. 1983;64(4):312-315
pages 312-315 views

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