Vol 62, No 3 (1981)

56 indicators of the blood coagulation and fibrinolysis system were studied in 866 men, healthy and suffering from coronary artery disease. Based on the mathematical analysis, tables of the significance of individual indicators for recognizing the clinical stages of coronary artery disease were compiled.

In 11 deaths from myocardial infarction and in the experiment in animals subjected to ligation of the anterior interventricular artery of the heart, the content of Na+ and K+ in the myocardium was determined. In the ischemic zone, the content of K+ is reduced, and Na+ is increased. These changes occur even before the appearance of morphological signs of myocardial infarction.

Ethanol, ß-naphthol (test for "fibrinogen B") and protamine sulfate tests, performed simultaneously in the blood plasma of patients with acute myocardial infarction, showed a high degree of correlation with each other, but they differed in sensitivity: ethanol> ß-naphthol> protamine sulfate. Heparin did not distort the results of the ethanol and β-naphthol tests, while the protamine sulfate test results strongly depended on the presence of heparin. The formation of a granular precipitate is not a positive protamine sulfate test and indicates hyperheparinemia. The ethanol test on the basis of data can be recommended to monitor the state of the hemocoagulation system in acute myocardial infarction, including the period of heparin therapy.

Analysis of radiographs of the lungs and case histories of 80 patients who were hospitalized for acute myocardial infarction revealed a direct relationship between the width of the right pulmonary artery and the value of the Moore index on the degree of stagnation in the pulmonary circulation. These values were greatest in alveolar pulmonary edema.

Treatment of patients with circulatory insufficiency of I and IIA stages with Siberian adonis provides a significant clinical effect; its influence on the dynamics of electrocardiogram indices, the phase structure of systole, the content of potassium and sodium in the blood and daily urine and the state of the minute blood volume is similar to the action of the spring adonis.

Treatment of cor pulmonale with vetrazine gave a pronounced therapeutic effect, indicating an improvement in hemodynamics in the pulmonary circulation and a decrease in the load on the right heart. The research results give reason to recommend the inclusion of vetrazine in the complex treatment of cor pulmonale.

The case histories of 360 patients with rheumatism were analyzed. Variants of the clinical course of primary and recurrent rheumatism are described. In view of the high frequency of latent and oligosymptomatic rheumatism, attention is drawn to the difficulties in diagnosing primary rheumatism proceeding according to the cardiac type, which is often the reason for its late diagnosis.

The operation technique for the surgical treatment of thromboangiitis obliterans of the lower extremities is described. 42 patients with stages II, III and IV ischemia were operated on. In the II Art. ischemia is recommended to perform tecectomy. In the III Art. ischemia in the presence of segmental occlusions tecectomy is combined with autovenous plastic or thromboendarterectomy.

The case histories of 81 patients with gynecological peritonitis were analyzed. 80.2% of patients with this complication were between the ages of 20 and 40. The use of local hypothermia along with drug therapy in the acute period and a rational regimen of nursing patients made it possible to reduce the percentage of surgical interventions to 13.6%, and mortality to 1.2%. The discharge of patients from the department with full rehabilitation contributed to a sharp decrease in the frequency of recurrence of inflammatory diseases.

A rheographic study of the blood supply to the facial muscles in patients with neuritis of the facial nerve and secondary contracture of the facial muscles was carried out. In the acute stage of neuritis, stagnant changes in the hemodynamics of the face were found. A significant difference in blood flow was revealed in patients with contracture of the facial muscles, depending on the presence of pain manifestations or their absence. Algic forms of contracture are characterized by a deterioration in both arterial inflow and venous outflow.

An analysis of the results of treatment of 124 patients with stage I cervical cancer showed that with a depth of invasion of up to 3 mm, the volume of surgical intervention can be reduced to a simple extirpation of the uterus without risk to the patient's health and life.

The medical histories of those who died from heart rupture (PC) were analyzed. Of the 1499 patients with myocardial infarction (MI) who were admitted to the specialized department for patients with myocardial infarction from 1972 to 1978, 221 died; PC was the direct cause of death in 56 of them (25.3%). MS was mainly observed in the elderly, more often in women than in men. In the 51-60 age group, PC occurred in 5 out of 284 men (1.8%) and in 3 out of 70 women (4.3%), in the 61-70 age group - in 8 out of 270, respectively (2.9 %) and 18 out of 191 (9.4%); in the group of MI patients over 70 years old - in 5 out of 107 (4.7%) and in 17 out of 155 (10.9%). In all patients, MS occurred against the background of transmural MI in the anterior wall region. More often MS was observed in primary MI (76.7%), in 2 cases with repeated MI (3.3%), in 12 with recurrent MI (20.0%). On the first day of myocardial infarction, cardiac rupture occurred in 30 patients, on days 2-3 - in 10, on 4-7 - in 2, on 19-23 - in 8. All cases of late ruptures (after 7 day) were associated with recurrent myocardial infarction.

It has now been established that the occurrence of Wolff-Parkinson-White (WPW) syndrome is directly related to the presence and functioning of additional muscular pathways through which excitation is carried out from the atria to the ventricles.

The clinical picture of nonparasitic liver cysts is characterized by poor symptoms and depends primarily on the size of the cyst, its location and complications. Patients complain mainly of dull and bursting pains in the right hypochondrium, epigastrium, as well as a feeling of discomfort and enlargement of the liver and abdomen.

The lipid complex (LC) of bile was studied by electrophoresis in polyacrylamide gel (PAGE) in 103 patients; in 86 with chronic non-calculous cholecystitis (30 children and 56 adults) and in 17 with chronic calculous cholecystitis (age - from 36 to 54 years). For control, we studied the lipid profile of bile in two age groups of 20 people in whom the diagnosis of cholecystitis was rejected after a thorough examination.

A complex of reasons plays a role in the occurrence of postoperative thrombosis, among which the leading place is occupied by an increase in the thrombogenic properties of blood, as well as a violation of its rheological properties. These circumstances were the reason for the development of a method for active management of the early postoperative period with the use of non-specific and specific prevention of thromboembolic complications.

For three years, dynamic observation and in-depth examination of workers in contact with lead was carried out. 420 people were examined - 130 women and 290 men. 35.5% of them were under the age of 30, the rest were older. 52.4% of the surveyed had a production experience of up to 10 years and 47.6% - more than 10 years. The control group (80 people) consisted of machine shop workers who worked in similar conditions, but without contact with lead.

A comprehensive physiological and hygienic examination of the working conditions of foremen of machine-building enterprises was carried out. The duties of the foremen include solving a number of organizational tasks, the implementation of which is associated with being directly in the shop for 60% of the working time. Physiological studies have established a decrease in the work capacity of foremen by the end of the working day due to an increase in fatigue.

A dry differential semi-synthetic medium to distinguish meningococci from non-pathogenic Neisseria was tested with 306 freshly isolated Neisseria strains. Tests have shown the high diagnostic value of the environment. It is convenient to prepare and easy to use.

May 5, 1981 marked the 60th anniversary of his birth and 36 years of scientific, pedagogical and social activities of the head of the Department of Normal Human Anatomy of the Kazan Medical Institute, Honored Scientist of the TASSR, Professor Alexander Grigorievich Korotkov.