Vol 81, No 2 (2000)

Formulary system of drug supply and its formation in the republic of tatarstan

Ziganshina L.E., Galiullin N.I., Safiullin R.S., Gazizova N.T., Ziganshin A.U.


Currently, according to WHO, at least 70% of drugs on the world market are duplicates or are not vital drugs. A number of drugs have an unfavorable balance of risk and effect. According to indications, many new drugs do not meet the basic needs of the majority of the population; they are much more expensive than existing drugs. A stable trend in recent years on a global scale is an increase in the cost of drugs, according to WHO experts, by an average of 20% per year, and those that are most often used by the majority of the population (antiulcer, antihypertensive drugs and antibiotics) [1]. In such conditions, the problem of rational use of drugs becomes extremely urgent. In daily practice, doctors need to make the choice of a drug for a particular patient, thereby ensuring the maximum therapeutic effect at a reasonable cost. This choice of medicinal product must be scientifically based.

Kazan medical journal. 2000;81(2):81-85
pages 81-85 views

Healthcare mangement

Ways to improve the efficiency of pharmacies

Tukhbatullina R.G., Safiullin R.S.


The financial and economic analysis of the pharmaceutic institutions of Tatarstan is performed. It is established that in conditions of deficiency of turnover means the pharmaceutic institutions do not use bank credits. The concrete model of using bank credit for increasing the efficiency of pharmacy activities, availability and quality of medicinal aid to population is suggested.

Kazan medical journal. 2000;81(2):86-86
pages 86-86 views

Marketing research in the field of drug supply for patients with diabetes mellitus

Khusainova G.I., Shakirova D.K.


Diabetes mellitus (DM) is the most acute medical and social problem and belongs to the priorities of national health systems in almost all countries of the world, protected by WHO regulations [7]. The drama and urgency of the problem are determined by the widespread prevalence of diabetes mellitus, high mortality and early disability of patients [1].

Kazan medical journal. 2000;81(2):89-91
pages 89-91 views

Optimal structure of the pharmaceutical market in the context of the privatization of pharmacies

Muslimov N.N., Latypova G.R.


The socialogic studies among pharmaceutic institutions managers, chemists and pharmacists are carried out. The positive attitude of these employees to privatization was revealed by questionnaire. However, as for now the pharmacetic managers prefer transition of the property in the form closed joint- stock company as more gradual way of reforms.

Kazan medical journal. 2000;81(2):87-88
pages 87-88 views

Relevance of the problem of preferential drug provision in the Republic of Tatarstan

Safiullin R.S., Nuzhnova T.I., Yarkaeva F.F.


In connection with significant structural changes in the Republic of Tatarstan associated with market transformations and a deficit of budgetary funds, providing the population with medicines and medical products on preferential terms is one of the problems that have sharply aggravated in recent years and have thus become of major social importance. Currently, more than 1 million people enjoy the right to preferential purchase of medicines in the Republic of Tatarstan.

Kazan medical journal. 2000;81(2):92-94
pages 92-94 views

Pricing for medical products in the context of non-monetary forms of payment

Akhmetzyanov I.M.


The various forms of accounts used in financing practical health system as a factor determining the formation of prices on medical products are studied. The practical experience of organizing purchases of medical products using various forms of accounts is analyzed. The possibility of the effect on the reduction of prices of medical products in nonmonetary payments including interpayments, barter is shown on the concrete examples. The neccesity to study raw material market for using the industrial potential of the region providing delivery of medical products at prices lower than market ones is shown. The recommendations on optimizing the schemes of delivery of medical products into medical prophylactic institutions with maximum economy of budget means are suggested.

Kazan medical journal. 2000;81(2):95-100
pages 95-100 views

Theoretical and clinical medicine

The nature of changes in collagen metabolism in iron deficiency anemia

Nikitin E.N., Korepanov A.M., Eremenko L.L., Sharaev P.N., Nazarov A.M.


Collagen metabolism parameters are studied in 48 females aged 17—53 with iron-deficiency anemia. This protein metabolism state is estimated on the basis of determining the concentration of free and peptide- and protein-connected hydroxyproline forms in plasma and gastric juice of the patients. The significant decrease of this protein anabolism processes is revealed in relative predominance of this catabolism in the organism of the observed patients.

Kazan medical journal. 2000;81(2):101-102
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Phenotype of peripheral blood lymphocytes in angina

Mustafin I.G., Fazylov V.K., Baryshnikov A.O.


The phenotype of peripheric blood lymphocytes is studied in 87 patients with angina by cytofluorimetry. It is shown that the course of the disease is accompanied by significant changes of the phenotype of lymphocytes: the increase of expression of activation markers, the increase of the content of CD16+cells. However, the changes of the phenotype of lymphocytes in groups of patients with lacunar and ulceromembranous anginas are ambiguous in the acute period of the disease as well as late in the observation.

Kazan medical journal. 2000;81(2):103-107
pages 103-107 views

Pharmaco-epidemiological analysis of approaches to the prescription of antibacterial drugs in the treatment of acute respiratory viral infections in children

Ziganshina L.E., Pikuza O.I., Maksumova D.R., Koroleva O.I.


The pharmacoepidemic analysis of 500 clinical charts of children aged 1 day to 15 years on the basis of 7 pediatric polyclinics is earned out. If the indications and quality of prescribing antibacterial drugs in acute respiratory viral infections are taken into account, their injustified use is established in 36,5% of the cases, the discrepancy between standard doses on a number of drugs is established in 33—61,5% of the cases. This justifies the necessity of phamiacoepidemic monitoring of pharmacotherapy of patients with acute respiratory viral infections.

Kazan medical journal. 2000;81(2):108-109
pages 108-109 views

Preparation and study of polycomplex matrix systems containing ibuprofen

Mustafin R.I., Vasilyeva E.A.


The solution to the problem of creating microencapsulated drugs (MP) with prolonged action is the search for polymer excipients with film-forming properties that ensure long-term maintenance of the therapeutic level of drug concentration in the blood and meet the requirements of pharmaceutical technology. Interpolymer complexes (IPCs) are of considerable interest, the structural features and properties of which allow them to be used as polymer carriers in the technology of microencapsulated and tableted preparations [1-4].

Kazan medical journal. 2000;81(2):110-113
pages 110-113 views

X-ray computed tomography and magnetic resonance imaging in the recognition of multiple sclerosis

Kamalov I.I., Matveeva T.V., Appakova A.Z., Kamalova L.I.


The comparicon of diagnostic possibilities of x- ray computer tomography and magnetic resonance tomography in detecting disseminated sclerosis and its evolution is performed. Demyelinizating foci in the second examination method are revealed twice as often than in the first examination method at the expense % of the double relaxation. Selection of the treatment tactics and prediction of disseminated sclerosis determine various forms of its course.


Kazan medical journal. 2000;81(2):114-116
pages 114-116 views

The value of the method of ultrasound diagnostics in the system of diagnostic and consultative-diagnostic centers

Bakirov R.S., Khasanov Z.I.


The examination of 20000 patients revealed coincidence of by the ultrasonic and preliminary diagnosis in the diseases of hepatopancreatobiliary system in 35,2% of the cases, urinary system —in 64,4% of the cases thyroid gland — in 90,7% of the cares. The practical importance of the ultrasonic investigation is determined by the study quickness, . the method has no side effects to doctor or patient, it can be repeated to control the changes of the disease course, to estimate the efficiency of medical measures, timely diagnosis of complications.

Kazan medical journal. 2000;81(2):117-118
pages 117-118 views

Hepatobiliscintigraphy in the diagnosis of bile leakage in the early postoperative period in patients with cholelithiasis

Farrakhov A.Z., Yusupova A.F., Valiullina P.M.


The importance of hepatobiliar scintigraphy in the diagnosis of complications in early postoperative period in patients operated for cholelithiasis is considered. The high efficiency of this noninvasive method as compared with ultrasonography is shown.

Kazan medical journal. 2000;81(2):119-120
pages 119-120 views

Intensive therapy and anesthesia for diffuse phlegmon of the neck and maxillofacial region, complicated by respiratory disorders and mediastinitis

Nazipov A.A., Surinov M.A.


The peculiarities of intensive therapy in 5 patients with Dupuytren’s phlegmons complicated by mediastinitis and respiratory distresses are considered. The prolonged artificial pulmonary ventilation in the positive pressure regime in the expiration end of prevents not only respiratory insufficiency but phlegmon propagation from lower neck parts into the chest, as well as improves mediastinum drainage.

Kazan medical journal. 2000;81(2):121-124
pages 121-124 views

Experience in the Treatment of Diverticular Colon Disease

Timerbulatov V.M., Mehdiev D.I., Zagidullin S.Z., Verzakova I.V., Mikheeva E.A., Kovalskaya S.F., Magafurov R.F.


The results of the treatment of 645 patients with the large intestine diverticulum (women — 65,4%, men — 34,6%) are analyzed. As many as 54,4% of the patients were hospitalized in case of emergency, 45,6% of the patients — in planned cases. The conservative treatment was given to 82,5% of the patients, the operative theatment — to 24,8% of the patients. In the hyperkinetic type of intestine motility, preference was given to low invasive operations conserving organs (in 28 cases the Reilly and Hodgson laparoscopic seromyotomt were carried out, in 17 cases — through miniaccess), in the hypokinetic type the various kinds of large intestine resections were carried out (in 20 cases). In cases of emergency depending on the general state of a patient, nature and incidence of the pathologic process, the possibility of choosing various intervention methods is presented (in 29 cases — the primary resection with anastomosis was carried out).

Kazan medical journal. 2000;81(2):125-128
pages 125-128 views

Classification of uterine perforations and medical tactics for them

Kozlov L.A., Khairutdinova S.G., Nigmatullina I.A., Sharafutdinova L.I.


The causes producing the uterus perforation and adequate medical tactics in this case are considered. The most suitable classification of the uterus perforations is presented. The recommendations on the prevention of this complication are given.

Kazan medical journal. 2000;81(2):129-132
pages 129-132 views

Psychological aspects of personality formation in children with chronic somatic diseases

Aron I.S.


The psychologic aspects of forming the personality of a child under school age with chronic, disease such as allergy are studied. The basic psychologic factors, determining the peculiarities of “social development situation” of children with allergy are revealed. The importance of personal features of parents in forming the personality of a sick child is emphasized.

Kazan medical journal. 2000;81(2):133-135
pages 133-135 views

The use of external fixation rods in the treatment of femoral fractures

Lushnikov E.V., Kovalenko N.A., Astakhov V.G.


The results of the treatment of patients with the femoral fractures using the rod apparatus for external fixation are analyzed. The basics for the estimation of the results are the anatomic, roentgenologic and functional possibilities of extremities as well as job performance. The indicators of remote results of the treatment confirmed the utility of using the rod apparatus of one-side external fixation in the treatment of the complicated femoral fractures.

Kazan medical journal. 2000;81(2):136-137
pages 136-137 views

Rationale for the use of xymedon in the complex therapy of patients with psoriasis

Galiullina L.A., Khafizyanova R.K., Mordovtsev V.I.


The use of the new home-made drug — ximedone in combined therapy of patients with psoriasis is justified. Its immunosimulating effect, normalizing influence on the immune status indices, the absence of side effects are shown making it possible to recommend ximedone for the treatment of patients of any age.

Kazan medical journal. 2000;81(2):138-140
pages 138-140 views


Modern advances in the development of neurotropic drugs

Nasibullina N.M.


Among the drugs that prevent the development of mental illness, the consequences of epilepsy and cerebral palsy, the use of neurotropic drugs in various dosage forms (DF) is considered promising and expedient [1, 4–9, 18]. Over the past 10-15 years, a large number of publications have been accumulated on the achievements in the development of highly active neurotropic drugs, which served as an impetus for the study of their pharmacological activity and mechanism of action. Nevertheless, among specialists involved in the search and development of nootropics, there is no single point of view regarding the classification of this group of drugs, which makes it very difficult to assess the drug market [5]. So, along with antidepressants, tranquilizers, anxiolytics and neuroleptics, in France, nootropics are referred to as psychotropic drugs, in Japan - to CNS stimulants, in Italy - to analeptics [6]. About 60 leading pharmaceutical companies in various countries of the world are engaged in the search and research of nootropic drugs [6].

Kazan medical journal. 2000;81(2):141-143
pages 141-143 views

Technology, study and use of anti-tuberculosis drugs isoniazid, pyrazinamide, rifampicin and ethambutol

Egoshina Y.A., Samartsev A.A., Potselueva L.A., Valiev R.S., Galiullina T.N.


At present, the effectiveness of the treatment of patients with tuberculosis in Russia has significantly decreased in comparison with the literature data for the period from 1992 to 1997. For example, the cure rates of patients with respiratory lesions decreased by 25.1%, abacillation - by 27%, closure of decay cavities - by 20.2% [4].

Kazan medical journal. 2000;81(2):144-145
pages 144-145 views

Methods for modeling in vitro percutaneous absorption of drugs from local dosage forms

Egorova S.N.


Transdermal absorption of medicinal substances (LP) proceeds as a two-stage process, consisting of penetration of drugs from dosage forms (LF) into the skin and absorption itself [4]. In biopharmaceutical studies, when choosing the optimal composition of dermal DF and studying the role of pharmaceutical factors affecting the release of drugs from LF, dialysis methods (equilibrium and flow) are widely used, designed to simulate both stages of transdermal absorption. A number of requirements are imposed on model membranes, which are a diffusion barrier: they must have an insignificant thickness and a small internal volume so that the amount of LS remaining in it is minimal; be sufficiently resistant to mechanical stress so that during the experiment its integrity is not violated; should provide a correlation between the results of experiments in vivo and in vitro [5, 6, 10].

Kazan medical journal. 2000;81(2):146-147
pages 146-147 views

Short articles

Effect of adenosine on the course of experimental pulmonary edema

Ovchinnikova A.G., Eliseev V.V., Krylova I.B.
Kazan medical journal. 2000;81(2):148-149
pages 148-149 views

Влияние эфорана на сократительную активность миометрия

Ziganshin A.U., Garayev R.S., Katamay G.A., Zaitsev A.P., Zaitseva I.P., Wiesel A.O.


Eforan - tributyl ester of 2-carboxypropylphosphonic acid - is a representative of low-toxic organophosphorus compounds. Currently, it is undergoing preclinical testing as an anti-inflammatory and antiseptic agent for gynecological purposes. As part of these studies, we studied the effect of eforan on the contractile activity of the uterus in experimental animals.

Kazan medical journal. 2000;81(2):149-149
pages 149-149 views

Study of the local irritating effect of suppositories with gabutamine

Sidullina S.A., Dementieva P.P.


In the practice of anticonvulsant therapy, a significant arsenal of drugs is used. In recent years, it has been established that nitrogen-containing derivatives of trichloromethylpropanoic acid are mainly low-toxic compounds with pronounced anticonvulsant and anti-tremor effects. Among them, one can distinguish a new original biologically active substance habutamine - 1,3dichloro-2-chloromethylaminopropane hydrochloride, obtained at the Kazan Research Institute of Chemical Products. Based on the pharmacological effect of gabutamine, studied at the Department of Pharmacology of the KSMU, and the possibility of its use in all age groups, a rational dosage form was proposed - rectal suppositories.

Kazan medical journal. 2000;81(2):149-150
pages 149-150 views

The phenomenon of acceleration of the conduction of excitation through the CNS in patients with tick-borne encephalitis

Remnev A.G., Nazarenko N.V., Schumacher G.I.


We have previously established that in the acute period of tick-borne encephalitis (TBE), which occurs with damage to the membranes and substance of the brain, the latent periods of recorded responses are increased. In dynamics, in the period of convalescence, these same patients showed an improvement in the conduction of excitation in the form of a decrease in the latent periods of the recorded responses. Due to the continued long-term disability (8-10 months after the acute period), 19 patients were referred for a consultation at the Bureau of Medical and Social Expertise to study the conduction pathways of the CNS. In 3 patients, signs of acceleration of the conduction of excitation were registered in comparison with the normal values ​​obtained in neurologically healthy patients.

Kazan medical journal. 2000;81(2):150-150
pages 150-150 views


Hygienic characteristics and rationalization of the nutritional status of railway workers

Zhilyaev N.S., Novikov Y.V., Istomin A.V., Artamonov S.V.


The labour conditions, actual alimentation and biochemical indicators of the health state of workers repairing railway tracks are studied. The revealed peculiarities of the alimentary status are the basis for developing the hygienic recommendations on alimentation optimization, their health improvement.

Kazan medical journal. 2000;81(2):151-154
pages 151-154 views


Silver jubilee of the Faculty of Pharmacy of Kazan State Medical University


At the turn of the century, 25 years have passed since that significant day, when in 1975 the first admission of students to the Faculty of Pharmacy of the Kazan State Medical University (then - the Institute) was carried out. The need to create such a faculty was dictated by the fact that the pharmaceutical faculties and institutes of the Soviet Union that existed by that time could not meet the needs of the Republic of Tatarstan and neighboring regions in highly qualified pharmaceutical specialists. Its opening in Kazan was associated with the presence of a higher medical educational institution with an established pharmacological school, an internationally recognized scientific school of organic chemists headed by academicians A.E. Arbuzov and B.A. Arbuzov, a developed chemical industry, as well as a large chemical and pharmaceutical enterprise. However, no matter how favorable these factors were, by themselves they could not lead to a positive outcome in the creation of the Faculty of Pharmacy. This event was destined to come true thanks to the initiative of several specific people, supported by the entire emerging teaching staff of the faculty.

Kazan medical journal. 2000;81(2):155-157
pages 155-157 views


The first department of allergology and the allergological service of the Republic of Tatarstan is 30 years old


In March 2000, the Allergology Department of the Kazan State Medical Academy and the Allergological Service of the Republic of Tatarstan celebrated its 30th anniversary. Created on the initiative of the rector of GIDUV prof. THEM. Rakhmatullina with the support of Academician of the Academy of Medical Sciences A.D. Ado, the department became the first base for the training of allergists in the USSR.

Kazan medical journal. 2000;81(2):157-157
pages 157-157 views

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