Vol 67, No 5 (1986)

The domestic tranquilizer mebicar attracted our attention. Previously, this drug was found to have antihypoxic, analgesic, stress-protective, and antiarrhythmic properties. This combination of effects can be very valuable in the treatment of patients with coronary heart disease. This paper evaluates the effectiveness of mebicar in the treatment of patients with angina pectoris; based on the results of a study by one of the authors, an experimental substantiation of the antianginal action of the drug is given.

Relatively late complications resulting from long-term smoking are well known, both from the lungs (chronic bronchitis, emphysema, lung cancer) and the cardiovascular system (atherosclerosis, coronary heart disease, arterial hypertension, etc.). We studied right ventricular contractility in young smokers. We observed 33 smokers aged 18 to 30 years and 35 age-matched healthy nonsmokers. All 68 subjects underwent complete clinical, laboratory and instrumental examination in a therapeutic clinic.

The purpose of this work was to clinically evaluate the efficacy of lithium electrophoresis in some thyroid diseases. We examined 28 patients with primary toxic diffuse goiter aged from 20 to 54 years (2 men and 26 women). Seventeen patients had mild thyrotoxicosis, nine had moderate, and two had severe thyrotoxicosis. Diffuse increase of thyroid gland of I-II degree was found in 22 patients, III - in 6 patients. thyrogenic ophthalmopathy of I-II degree was observed in 6 patients. Conservative antithyroid therapy was required in 23 patients, and 5 patients underwent strumulectomy.

Trigeminal neuralgia is one of the most severe and common forms of facial pain syndrome. Its etiology is varied. Most researchers characterize trigeminal neuralgia as a complex process in which the focus of irritation in the afferent part of the nerve causes changes in the stem and subcortical structures in the form of foci of pathological activity manifested by paroxysms.

Comprehensive anti-inflammatory treatment with intracutaneous antibiotic injection was performed in 20 patients under 30 years of age with acute inflammatory diseases of the appendages of the uterus. On admission, nine women were diagnosed with acute pelvio-peritonitis, six - with acute metoendometritis and bilateral salpingo-oophoritis, two - with acute purulent salpingo-oophoritis, two - with posterolateral parametritis and one - with diffuse peritonitis. Three women were admitted on the first day of the onset of the disease, the remaining 17 were admitted in the first 5 days.

The aim of this work was to study some indices of immunological reactivity in newborns with intrauterine hypotrophy of different genesis and peculiarities of their development during the first year of life. For this purpose, in 141 newborn infants with intrauterine hypotrophy (treatment group) and in 28 normotrophic children (control group) the general state at birth and the peculiarities of the adaptation period were evaluated. In 54 of them the immunoglobulin spectrum of blood serum, the level of circulating immune complexes and individual components of kininin system were studied.

The aim of this study was to compare the state of nonspecific resistance, cellular and humoral immunity in young children with acute respiratory infections with a smooth course, with the first episode of bronchoobstructive syndrome (BOS) and with recurrence of this syndrome.

We followed up 61 children with urate nephropathies. Of them there were 34 children aged from 1 to 7 years, from 8 to 14 years - 27. Dysmetabolic nephropathy proper, characterized by minimal clinical and laboratory manifestations, was diagnosed in 13 patients, interstitial nephritis of dysmetabolic genesis - in 18, secondary pyelonephritis developed against the background of disturbed purine metabolism - in 30, pyelonephritis due to urolithiasis - in 3.

Pickwick's syndrome is characterized by marked obesity, somnolence (daytime), intermittent breathing during night sleep, cyanosis, polycythemia, right ventricular hypertrophy, shortness of breath, decreased minute respiratory volume, alveolar ventilation volume, blood oxygen saturation, hypercapnia, right ventricular failure. In this disease there is so-called exogenous alimentary obesity with predominant deposition of fat in the subcutaneous tissue of the anterior abdominal wall.

Hypothalamic pubertal syndrome is a common disease of adolescence and adolescence that occurs during the period of physical status and personality formation. It is characterized by interstitial brain damage and hypothalamic-pituitary-endocrine dysregulation (hypercorticism, hyperaldosteronism, hyperprolactinemia, gonadotropin production disorders). Often this syndrome limits the fitness of young men and women for some professions requiring physical and emotional stress, in particular for military service.

In order to prevent complications in the department of anesthesiology and intensive care, we conducted a clinical trial of the above drug as a local antiseptic agent for fixation of the catheter located in the subclavian vein. Two identical groups of patients from different departments were formed by random sampling: neurosurgical, surgical, traumatological, pediatric surgery, ENT, and maxillofacial surgery. Group 1 consisted of 177 patients in whom the drug Lifusol was used for catheterization of the subclavian vein; 187 patients in Group 2 received catheter fixation by the usual method using adhesive plaster.

In the pathogenesis of scleroderma an essential role is played by intensive collagen biosynthesis, which causes the development of fibrotic-sclerotic lesions. In this connection, it is pathogenetically substantiated the use of agents, the effect of which is aimed at decreasing the synthesis and increasing the catabolism of collagen.

In this work we studied the possibilities of the unloading perimetric test depending on the glaucoma stage and the degree of visual field expansion along the meridians during the test.

A cumulative examination of 4,070 schoolchildren aged 7 to 14 years was conducted in Kazan. Symptoms of digestive tract lesions were found in 340 children. In addition to these patients 290 children with a history of gastroenterological risk factors were identified. Parents had gastroenterological diseases in 40% of those examined, 63% had chronic foci of infection, and 36.9% had acute gastrointestinal and parasitic diseases.

We studied the content of chondroitinseric acid, glucuronic acid, hexosamines, fucose, and N-acetylneuraminic acid, as well as the activity of trypsin-like proteases in the papule tissues (biopsied skin from the lesion focus, including papillary layer of derma, basal and thorny layers of epidermis) and in parakeratotic scales of 104 psoriasis patients (53 of them were diagnosed with progressing stage, 37 with stabilizing stage, 14 with regressing stage).

The high prevalence and progressive course of periodontal disease dictate the need for dispensary monitoring of these patients. We have more than 10 years of experience in specialized treatment of this category of patients. The work in the periodontal office is performed by two specially trained doctors and a nurse. Patients undergo laboratory and X-ray examinations, receive treatment, and there is also a patient record book.

Advances in pharmacy, pharmacology in recent years and the rapid development of the chemical-pharmaceutical industry have significantly expanded the arsenal of drugs used, the number of which continues to increase. With the introduction into practice of new drugs, the possibilities of etiotropic and pathogenetic therapy have increased. However, at the same time as the effectiveness of drug therapy has increased, it has become less safe. In recent years, cases of drug-induced side effects, which often exceed the severity of the underlying disease, have increased.