Vol 79, No 5 (1998)

The diagnostic allergens from yeast-like and mold fungi of 18 names are developed and studied. The drugs are polysaccharide — protein complexes, they do not contain toxic components and conservants. They are used for the diagnosis of sensibilization in vivo and in vitro as well as for immunotherapy.

On the basis of examination of 5020 patients during 1991—1997 it is concluded that each third patient had bronchobstructive syndrome. If in disseminated and fibrocavernous tuberculosis the aggravation of bronchi permeability was found in each second patient, so in chronic obstructive bronchitis — in all patients. At the same time in sarcoidosis, in idiopathic fibrosing alveolitis this syndrome was rarely found. The analysis of 155 cases of the use of atrovent as an acute test with broncholithic showed the high efficiency of this cholinoblockator in significant obstruction and minimal effect in patients without ventilational insufficiency.

It is established that in most of patients the course of atopic bronchial asthma occurs as clinical attacks of expiratory asphyxia repeated both by day and at night. In children aged 1 to 6 the course of this disease is principally slight, medium and grave. In elder age group (7—15 years) the share ef graver forms of bronchial asthma increases. The disease is determined by increased sensitivity to domestic allergens. Atypical forms are found only in young age group and obviously are not connected with hypersensitivity. The specific immunotherapy is an effective treatment method of the classical atopic bronchial asthma in children aged 7 to 15.

The concentration of antibodies to antigens Streptococcus pyogenes, li posaccharide E of the salt 0 14, Pseudomonas aeruginosa, Proteus mirabilis, Staphylococcus aureus, Candida albicans, Streptococcus pneumoniae as well as to endotoxin (glycolipid RE 595 S.Minnesota) of Gram — negative flora in patients with angina in the treatment dynamics is determined by the hardphase immunofermental analysis method. The data obtained show the low concentration of antibodies to staphylococcus, endotoxin of Gram — negative flora, Candida and the high concentration — to Pseudomonas aeryginosa for the whole time of observation. The changes revealed show the dysbalance in specific humoral immunity in patients with angina. The new drug — ximedone normalizes the state of humoral antibacterial immunity in patients with angina.

The examination results of the humoral immune response in children with allergodermatosis and in healthy children of various age groups are presented. The following immune diagnosis methods are used: the determination of the basic class immunoglobulins content, complement activity and general Ig E level. The markers for the immune status estimation and atopic type response prediction taking into account the immune system ontogenesis are proposed.

The use of riboxin in atopic dermatosis and urticaria allows to increase significantly the efficiency of the treatment: to decrease the acute period and hospitalization time of children as well as to increase the remission time. The use of riboxin is recommended in the treatment and rehabilitation of children with acute and chronic forms of allergodermatoses.

The state of cellular and humoral components of the immune system, phagocytic activity of peri pheric blood neutrophiles in 76 puerperas in late postnatal period is studied. The changes in the immune system response depending on the delivery method, the presence of postnatal complication as endometritis are revealed in puerperas with the complicated course of postnatal period. The pronounced changes in immune status confirming the developed second immunodeficiency accompanied by the gravest course of postnatal endometritis are revealed in puerperas with the complicated course of postoperative period.

The considerable increase of the free fatty acids part, phospholipid lysophorms and the decrease of the main membrane lipids level are found in tissue lipids spectrum in peritonitis. The changes in organ li pids composition in many cases are correlated with those in blood plasma. Hence, the complex estimation of blood li pids is an adequate method of determining the biochemical lipid disorders intensity on the organ level.

Urticaria is one of the most common diseases. All age groups are affected by this nosological form. Differences in etiological factors and body reactivity determine the variety of clinical forms of urticaria, the treatment of which requires a differentiated approach.

The allergological service in the city of Nizhnekamsk has existed since 1982. The city is located in the zone of influence of a large petrochemical production, which leads to an increase in allergic and bronchopulmonary pathologies, including bronchial asthma of exo- and endogenous origin.

Malaria is a serious problem in developing countries. Currently, mortality from it varies from 1.5 to 2.7 million people per year, and the incidence - from 300 to 500 million people annually. Social and economic losses in Africa alone are estimated at US $ 1.8 billion per year (Kondrashin, Traig, 1996).