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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">64542</article-id><article-id pub-id-type="doi">10.17816/kazmj64542</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Formation of humoral immune response in atopic dermatitis in children</article-title><trans-title-group xml:lang="ru"><trans-title>Становление гуморального иммунитета при атопическом дерматите у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Agafonova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Агафонова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pediatric Diseases, Faculty of General Medicine, Department of Dermatovenereology</p></bio><bio xml:lang="ru"><p>Кафедра детских болезней лечебного факультета, Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malanicheva</surname><given-names>T. G.</given-names></name><name xml:lang="ru"><surname>Маланичева</surname><given-names>Т. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pediatric Diseases, Faculty of General Medicine, Department of Dermatovenereology</p></bio><bio xml:lang="ru"><p>Кафедра детских болезней лечебного факультета, Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamov</surname><given-names>B. A.</given-names></name><name xml:lang="ru"><surname>Шамов</surname><given-names>Б. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Professor, Head of the Department of Childhood Diseases, Faculty of General Medicine, Department of Dermatovenereology</p> <p> </p><p> </p> </bio><bio xml:lang="ru"><p>Профессор, заведующий кафедрой детских болезней лечебного факультета, Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Medical University</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1998-09-14" publication-format="electronic"><day>14</day><month>09</month><year>1998</year></pub-date><volume>79</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>363</fpage><lpage>366</lpage><history><date date-type="received" iso-8601-date="2021-04-02"><day>02</day><month>04</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-04-02"><day>02</day><month>04</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1998, Agafonova E.V., Malanicheva T.G., Shamov B.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1998, Агафонова Е.В., Маланичева Т.Г., Шамов Б.А.</copyright-statement><copyright-year>1998</copyright-year><copyright-holder xml:lang="en">Agafonova E.V., Malanicheva T.G., Shamov B.A.</copyright-holder><copyright-holder xml:lang="ru">Агафонова Е.В., Маланичева Т.Г., Шамов Б.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/64542">https://kazanmedjournal.ru/kazanmedj/article/view/64542</self-uri><abstract xml:lang="en"><p>The examination results of the humoral immune response in children with allergodermatosis and in healthy children of various age groups are presented. The following immune diagnosis methods are used: the determination of the basic class immunoglobulins content, complement activity and general Ig E level. The markers for the immune status estimation and atopic type response prediction taking into account the immune system ontogenesis are proposed.</p></abstract><trans-abstract xml:lang="ru"><p>Формирование и развитие аллергических заболеваний у детей тесно связаны с изменениями иммунной системы. При атопическом дерматите (АД) доказана роль дисфункций гуморального иммунного ответа [2, 3]. Система синтеза иммуноглобулинов у детей в различные возрастные периоды не является статичной, она находится в состоянии нелинейной прогрессии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Краснов В.М., Ботвиньева В.В. Иммунологическая реактивность детей. — Чебоксары, 1993.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Куваева И.Б., Ладодо К.С. Микробиологические и иммунные нарушения у детей. — М., 1991.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Пыцкий В.И., Андриянова Н.В., Артамасова А.В. Аллергические заболевания. — М., 1991.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Стефани Д.В., Вельтищев Ю.Е. Иммунология и иммунопатология детского возраста. — М., 1996.</mixed-citation></ref></ref-list></back></article>
