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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">64546</article-id><article-id pub-id-type="doi">10.17816/kazmj64546</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Effect of ximedone on the state of humoral antibacterial immunity in patients with angina</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние ксимедона на состояние гуморального антибактериального иммунитета у больных ангиной</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zinkevich</surname><given-names>O. D.</given-names></name><name xml:lang="ru"><surname>Зинкевич</surname><given-names>О. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Professor, Head of the Laboratory of Immunochemistry, Department of Infectious Diseases</p></bio><bio xml:lang="ru"><p>Профессор, заведующий лаборатории иммунохимии, Кафедра инфекционных болезней </p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kravchenko</surname><given-names>I. E.</given-names></name><name xml:lang="ru"><surname>Кравченко</surname><given-names>И. Э.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Infectious Diseases, Laboratory of Immunochemistry</p></bio><bio xml:lang="ru"><p>Кафедра инфекционных болезней, Лаборатория иммунохимии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fazylov</surname><given-names>V. K.</given-names></name><name xml:lang="ru"><surname>Фазылов</surname><given-names>В. Х.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Professor, Head of the Department of Infectious Diseases, Laboratory of Immunochemistry</p> <p> </p><p> </p> </bio><bio xml:lang="ru"><p>Профессор, заведующий кафедрой инфекционных болезней, Лаборатория иммунохимии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Safina</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Сафина</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Infectious Diseases, Laboratory of Immunochemistry</p></bio><bio xml:lang="ru"><p>Кафедра инфекционных болезней, Лаборатория иммунохимии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Platonov</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Платонова</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Infectious Diseases, Laboratory of Immunochemistry</p></bio><bio xml:lang="ru"><p>Кафедра инфекционных болезней, Лаборатория иммунохимии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Urazaev</surname><given-names>R A.</given-names></name><name xml:lang="ru"><surname>Уразаев</surname><given-names>Р. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Infectious Diseases, Laboratory of Immunochemistry</p></bio><bio xml:lang="ru"><p>Кафедра инфекционных болезней, Лаборатория иммунохимии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan NIIEM</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Kazan State Medical University</institution></aff><aff><institution xml:lang="ru">Казанский НИИЭМ</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Kazan State Medical University</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Kazan NIIEM</institution></aff><aff><institution xml:lang="ru">Казанский НИИЭМ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1998-09-14" publication-format="electronic"><day>14</day><month>09</month><year>1998</year></pub-date><volume>79</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>354</fpage><lpage>358</lpage><history><date date-type="received" iso-8601-date="2021-04-02"><day>02</day><month>04</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-04-02"><day>02</day><month>04</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1998, Zinkevich O.D., Kravchenko I.E., Fazylov V.K., Safina N.A., Platonov O.A., Urazaev R.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1998, Зинкевич О.Д., Кравченко И.Э., Фазылов В.Х., Сафина Н.А., Платонова О.А., Уразаев Р.А.</copyright-statement><copyright-year>1998</copyright-year><copyright-holder xml:lang="en">Zinkevich O.D., Kravchenko I.E., Fazylov V.K., Safina N.A., Platonov O.A., Urazaev R.A.</copyright-holder><copyright-holder xml:lang="ru">Зинкевич О.Д., Кравченко И.Э., Фазылов В.Х., Сафина Н.А., Платонова О.А., Уразаев Р.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/64546">https://kazanmedjournal.ru/kazanmedj/article/view/64546</self-uri><abstract xml:lang="en"><p>The concentration of antibodies to antigens Streptococcus pyogenes, li posaccharide E of the salt 0 14, Pseudomonas aeruginosa, Proteus mirabilis, Staphylococcus aureus, Candida albicans, Streptococcus pneumoniae as well as to endotoxin (glycolipid RE 595 S.Minnesota) of Gram — negative flora in patients with angina in the treatment dynamics is determined by the hardphase immunofermental analysis method. The data obtained show the low concentration of antibodies to staphylococcus, endotoxin of Gram — negative flora, Candida and the high concentration — to Pseudomonas aeryginosa for the whole time of observation. The changes revealed show the dysbalance in specific humoral immunity in patients with angina. The new drug — ximedone normalizes the state of humoral antibacterial immunity in patients with angina.</p></abstract><trans-abstract xml:lang="ru"><p>С общепатологической точки зрения, основой и патогенетической сущностью банальной ангины является острое воспаление как универсальный способ реализации защитного потенциала организма в ответ на бактериальное повреждение</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Анохин В.А., Хасанова Г.Р. // Педиатрия. - 1994.-№6.-С. 8-10.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Апполонин А.В., Яковлев М.Ю., Рудин А.А. и др.//Журн, микробиол. — 1990.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Бидненко С.И., Назарчук Л.В. и ф.//Журн. микробиол. — 1992. — № 1. — С.ЗЗ—36.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Киселев П.Н. 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