Diagnosis, prevention and organ-preserving method of delivery in pregnant women with placenta accreta

Cover Page


Cite item

Abstract

The article considers one of the causes of maternal mortality - uterine postpartum bleeding developing as a result of the placental growth into the uterus and surrounding organs. It is highlighted that the processes of trophoblast invasion during pregnancy and tumor progression have much in common. The article describes a significant role of Kiss1-gene and its receptor GPR54 in the placenta accreta development. The causes of placental abnormalities and conventional methods of treatment and surgical management in placenta accreta (controlled uterine balloon tamponade, uterine vessels ligation, uterine compression sutures, uterine artery embolization, internal iliac arteries ligation, temporary clamping or major uterine vessels ligation, hysterectomy, «Triple-P» method) are analyzed, the possible complications of these methods of treatment are listed. The developed at the Department of Obstetrics and Gynecology №1 of Kazan State Medical University examination algorithm when planning pregnancy, gestation management and organ-preserving method of delivery in pregnant women with abnormal placental attachment is presented. Used by authors methods of uterine scar examination after organ-preserving surgery or caesarean section in women in the non-pregnant state (hysterography, hysteroscopy, ultrasound scan, double-contrast study) and sonographic signs of scar failure (myometrial thinning in the scar area, irregular contour of the scar, discontinuous contours of the scar, significant number of hyperechoic inclusions, presence of non-vascular liquid formations in the scar area, triangle in the scar area) are listed. Interesting illustrative material is also presented.

About the authors

A A Khasanov

Kazan State Medical University

Author for correspondence.
Email: albirkhasanov@mail.ru

References

  1. Груздев В.С. Курс акушерства и женских болезней. Часть 2. Акушерство. В 2 т. Берлин. 1922; 1: 628.
  2. Курцер М.А., Лукашина М.В., Панин А.В. и др. Истинное врастание плаценты. Органосохраняющие операции. Вопр. гинекол., акушерства и перинатол. 2009; 8 (5): 31-35.
  3. Милованов А.П. Патология системы «мать-плацента-плод». М.: Медицина. 1999; 448 с.
  4. Doumouchtsis S.K., Arulkumaran S. The morbidly adherent placenta: an overview of management options. Acta Obstet. Gynecol. Scand. 2010; 89 (9): 1126-1133. http://dx.doi.org/10.3109/00016349.2010.503869
  5. Bilban M., Ghaffari-Tabrizi N., Hintermann E. et al. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. J. Cell Sci. 2004; 117 (8): 1319-1328. http://dx.doi.org/10.1242/jcs.00971
  6. Oyelese Y., Smulian J.C. Placenta previa, placenta accreta, and vasaprevia. Obstet. Gynecol. 2006; 107 (4), 927-941. http://dx.doi.org/10.1097/01.AOG.0000207559.15715.98
  7. Beard J. The enzyme treatment of cancer and its scientific basis. London: Chatto and Windus. 1911.
  8. Ohtaki T., Shintani Y., Honda S. et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G protein-coupled receptor. Nature. 2001; 411: 613-617. http://dx.doi.org/10.1038/35079135
  9. Dinh T.V., Bedi D.G., Salinas J. Placenta membranacea previa and accreta. J. Reprod. Med. 1992; 37 (1): 97-99.
  10. Kanal E., Borgstede J.P., Barkovich A.J. et al. American College of Radiology White Paper on MR Safety: 2004 update and revisions. Am. J. Roen-tergenol. 2004; (182): 1111-1114.
  11. Horikoshi Y., Matsumoto H., Takatsu Y. et al. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J. Clin. Endocrinol. Metab. 2003; 88: 914-919. http://dx.doi.org/10.1210/jc.2002-021235
  12. Takino T., Koshikawa N., Miyamori H. et al. Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. Oncogene. 2003; 22 (30): 4617-4626.
  13. Schmid K., Wang X., Haitel A. et al. KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohis-tochemical study. Virchows Archiv. 2007; 450 (2): 143-149. http://dx.doi.org/10.1007/s00428-006-0352-9
  14. Jordan N.V., Johnson G.L., Abell A.N. Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer. Cell Cycle. 2011; 10 (17): 2865-2873. http://dx.doi.org/10.4161/cc.10.17.17188
  15. Maymo J.L., Perez A.P., Gambino Y. et al. Review: Leptin gene expression in the placenta - regulation of a key hormone in trophoblast proliferation and survival. Placenta. 2011; 32 (2): S146-S153. http://dx.doi.org/10.1016/j.placenta.2011.01.004
  16. Tao Y., Pinzi V., Bourhis J., Deutsch E. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway-therapeutic perspectives in cancer. Nat. Clin. Pract. Oncol. 2007; 4 (10): 591-602. http://dx.doi.org/10.1038/ncponc0934
  17. West A., Vojta P.J., Welch D.R., Weissman B.E. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). Genomics. 1998; 54 (1): 145-148. http://dx.doi.org/10.1006/geno.1998.5566
  18. Ohtaki T., Shintani Y., Honda S. et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G protein-coupled receptor. Nature. 2001; 411: 613-617. http://dx.doi.org/10.1038/35079135
  19. Tena-Sempere M. GPR54 and kisspeptin in reproduction. Human Reprod. Update. 2006; 12: 631-639. http://dx.doi.org/10.1093/humupd/dml023

© 2016 Khasanov A.A.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.





This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies