Effect of combined treatment of hypertension with cristepine and obzidan on hemodynamics and parameters of the renin-aldosterone system

Abstract

The aim of the present study was to study the effect of combined therapy with ß-blocker obzidan (40-80 mg per day) and cristepine (2-3 tablets per day) on central hemodynamics and indices of renin activity and blood plasma aldosterone level. We observed 67 patients with grade II hypertension aged 35 to 60 years. Hypertension was diagnosed by excluding all possible forms of symptomatic arterial hypertension. Its cerebral manifestations - headaches, dizziness, darkening of the eyes, nausea - dominated in the disease clinic.