Activity of blood cholinesterases upon administration of muscle relaxants

Abstract

With repeated injections of depolarizing muscle relaxants, a “double” block of the type of competitive can occur due to the accumulation of succinyl monocholine in the blood [11, 12, 13, 14]. Payne (1959) considers the division of muscle relaxants into depolarizing and non-depolarizing as relative. All of them act in two phases: if succinylcholine acts for a sufficiently long time, then the depolarizing block is replaced by a competitive one. The depolarization phase is extremely short in D-tubocurarine and its synthetic analogs. In succinylcholine, the first phase is longer and the second does not always occur.