The structure of intestinal infections in the infectious department

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Background. Every year in Russia, the number of patients with acute intestinal infections of unknown etiology remains at a significant level.

Aim. To determine the current etiological structure and features of the clinical course of acute intestinal infections in the infectious diseases department of a city hospital.

Material and methods. For the period from 2017 to 2019, 181 patients with manifestations of acute intestinal infections, who were in the infectious departments of the “City Hospital No. 5, Barnaul”, were examined. The age of the patients ranged from 18 to 76 years (mean age 35.4±14.8 years), including 55.6% females and 44.4% males. The study of biological material from patients (feces) was performed using polymerase chain reaction with hybridization-fluorescence detection, bacteriological examination and serological method (indirect hemagglutination reaction) for the presence of antibodies to pathogens of acute intestinal infections (in blood serum). The statistical significance of differences was assessed by the χ2 test.

Results. Out of 181 patients with acute intestinal infections, 108 (59.7%) had the etiology of the disease, of which 54 (50%) patients had an infection of viral etiology, including in the form of monoinfection — in 45 cases, and caused by a combination of two viruses — in 9 cases. In 41 (38%) patients, acute intestinal infections of bacterial etiology were diagnosed, including a combination of two pathogens in 4 cases, and three pathogens in 1 case. 13 patients had viral-bacterial intestinal infections. As a result of the survey, on the existing list of laboratory tests, the etiology of intestinal infection was not established in 73 (40.3%) patients. In patients with acute intestinal infection of bacterial etiology, the disease proceeded more severely, with higher body temperature and colitis, in patients with intestinal infection of viral etiology — with gastroenteritis.

Conclusion. A high proportion of intestinal infections of viral etiology (up to 50%) with etiological dominance of noroviruses has been established. Among the causative agents of bacterial acute intestinal infections, Campylobacter and Salmonella prevailed.

Full Text

Restricted Access

About the authors

Marina A. Nikonorova

Altai state medical University

Author for correspondence.
ORCID iD: 0000-0001-6621-9310
SPIN-code: 5396-5198

M.D., D. Sci. (Med.), Prof., Depart. of Infectious Diseases

Russian Federation, Barnaul, Russia

Nina V. Karbysheva

Altai state medical university


M.D., D. Sci. (Med.), Prof., Head, Depart. of Infectious Diseases

Russian Federation, Barnaul, Russia

Elena F. Kotovshchikova

Altai state medical university

ORCID iD: 0000-0002-3246-5609

M.D., D. Sci. (Med.), Prof., Head, Depart. of Propaedeutics of Internal Diseases named after Professor Z.S. Barkagan

Russian Federation, Barnaul, Russia

Ekaterina Shevtsova

Altai state medical university

ORCID iD: 0000-0001-8342-3110

M.D., PhD Stud., Depart. of Infectious Diseases

Russian Federation, Barnaul, Russia

Olga V. Beskhlebova

Altai state medical university

ORCID iD: 0000-0003-4561-1019
SPIN-code: 5033-5574

M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Infectious Diseases

Russian Federation, Barnaul, Russia


  1. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2019 godu. Gosudarstvennyy doklad. (On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2019. State report.) M.: Federal'naya sluzhba po nadzoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka; 2020. 299 р. (In Russ.)
  2. vedushchikh prichin smerti v mire. Informatsionnyy byulleten; 2020. (Top 10 causes of death in the world. WHO fact sheet, 2020.) (access date: 19.07.2020. (In Russ.)]
  3. Usenko DV, Gorelova EA. Acute intestinal infections of viral etiology in children: possibilities of diagnosis and therapy. Meditsinskiy sovet. 2017;(9):86–92. (In Russ.) doi: 10.21518/2079-701X-2017-9-86-92.
  4. Bobrova NK, Vorob’yeva OA. Modern clinical and epidemiological features of the course of rotavirus infection in adults. Zabaykal′skiy meditsinskiy vestnik. 2020;(1):7–11. (In Russ.)
  5. Molochnyy VP, Kopachevskaya KA, Zavartseva LI, Shchegoleva IE, Ko-rovayeva NV. On the rationality of the existing practice of empirical antibiotic therapy in young children with acute intestinal infections. Dalnevostochnyy meditsinskiy zhurnal. 2017;(1):47–51. (In Russ.)
  6. Sergevnin VI, Kuzovnikova EZh, Tryasolobova MA. Intra-annual dynamics of the epidemic process of acute intestinal infections and the reasons for its nature. Meditsinskiy alfavit. 2017;2(18):32–33. (In Russ.)
  7. Grizhevskaya AN, Ostrovskaya OS, Lyahovskaya NV, Khnykov AM. Structure of hospitalized acute intestinal infections in 2015–2016 In: Dostizheniya fundamental'noy, klinicheskoy meditsiny i farmatsii. Materialy 72-y nauchnoy sessii sotrudnikov universiteta. (Achievements of fundamental, clinical medicine and pharmacy. Materials of the 72nd scientific session of university staff.) Vitebskiy gosudarstvennyy meditsinskiy universitet; 2017. р. 76–78. (In Russ.)
  8. Antipov MO, Mindlina AYa. Epidemiological characteristics of the most urgent diseases of the digestive system of an infectious nature in the regions of Russia. Profilakticheskaya meditsina. 2020;(3):76–80. (In Russ.) doi: 10.17116/profmed20202303176.
  9. Lyubeznova ON, Utenkova EO. Rotavirus and norovirus infections in adults. Meditsinskiy vestnik Severnogo Kavkaza. 2017;(1):32–35. (In Russ.)
  10. Yakovlev AA, Ivanova EN, Kotlyarova SI, Karnaukhov EV, Gorbova IV. Mono- and co-infected with viruses forms of salmonellosis in adults. Zhurnal infektologii. 2013;(3):13–18. (In Russ.)
  11. Nikonorova MA, Saldan IP, Karbysheva NV, Pak SG, Belaya OF, Bobrovskiy EA, Yakimenko EA, Nemilostiva EA. Acute intestinal infections in outpatient practice. Epidemiologiya i infektsionnyye bolezni. 2018;(2):85–88. (In Russ.) doi: 10.18821/1560-9529-2018-23-2-85-88.
  12. Kapustin DV, Sokolov SN, Khokhlova NI, Krasnova EI, Tikunova NV. Viral diarrhea in the structure of acute intestinal infections in adult residents of Novosibirsk. Meditsina i obrazovaniye Sibiri. Spetsial′nyy vypusk. 2016. text_full.php?id=2048. (access date: 26.01.2020). (In Russ.)
  13. Privalova MA, Silayeva VV, Puzyryova LV, Bardina NV. Acute intestinal infections in the Omsk region in 2013–2015. Sibirskiy meditsinskiy vestnik. 2017;(2):24–30. (In Russ.)
  14. Nikonorova MA, Karbysheva NV, Beskhlebova OV, Shevtsova EA, Suzopov EV. Verification of the etiology of intestinal infections (viral/bacterial). Certificate of registration of the computer program 2021616311, 20.04.2021. Application No. 2021615206 dated 12.04.2021. (In Russ.)
  15. Pawlowski SW, Warren CA, Guerrant R. Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology. 2009;136(6):1874–1886. doi: 10.1053/j.gastro.2009.02.072.

Supplementary files

There are no supplementary files to display.

© 2022 Eco-Vector

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies