Features of immunity in patients with diphtheria
- Authors: Lebenzon S.S.1,2, Mayansky D.N.1,2, Spiridonova E.A.1,2, Vasyunin A.V.1,2, Altukhova I.V.1,2, Garbuzova S.B.1,2
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Affiliations:
- Novosibirsk Medical Institute
- Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
- Issue: Vol 63, No 5 (1982)
- Pages: 41-42
- Section: Articles
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/64519
- DOI: https://doi.org/10.17816/kazmj64519
- ID: 64519
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Abstract
The indices of humoral and cellular immunity were studied in 10 patients with typical and 7 atypical (carriage) forms of diphtheria infection. The highest level of antibodies (4.25 ± 1.2 AU / ml) was in carriers of diphtheria bacteria, and the lowest (0.07 AU / ml) was in patients with toxic diphtheria. Disturbances in the structure of cellular immunogomeostasis - a decrease in the total number of T-lymphocytes, an increase in Ta-ROK, an increase in the functional activity of phagocytic neutrophils and peripheral blood monocytes - were found in all and were most pronounced in patients with toxic diphtheria. In children, according to epidemiological indications, vaccinated with ADS, while the number of T-lymphocytes was preserved, all other studied parameters turned out to be increased.
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About the authors
S. S. Lebenzon
Novosibirsk Medical Institute; Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
Author for correspondence.
Email: info@eco-vector.com
Russian Federation
D. N. Mayansky
Novosibirsk Medical Institute; Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation
E. A. Spiridonova
Novosibirsk Medical Institute; Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation
A. V. Vasyunin
Novosibirsk Medical Institute; Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation
I. V. Altukhova
Novosibirsk Medical Institute; Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation
S. B. Garbuzova
Novosibirsk Medical Institute; Institute of Clinical and Experimental Medicine, Siberian Branch of the USSR Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation
References
- Покровский В. И., Авербах М. М„ Литвинов В. И., Рубцов И. В. Приобретенный иммунитет и инфекционный процесс. М., Медицина, 1979.
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