On the cellular response of the body in acute rheumatism

The modern view of acute rheumatism as a disease with an underlying allergic state of the organism is shared by most authors. Aschoff first noted in acute rheumatism the formation of specific granulomas in the myocardium. Subsequent studies by Talalaev, Klinge and others made it possible to establish a certain regularity in the development of Aschoff granulomas (stage of disorganization of connective tissue, stage of proliferation and stage of sclerosis development). These anatomo-histological changes observed in acute rheumatism are similar to the changes in the inflammatory focus of sensitized animals, on the basis of which most authors recognize that acute rheumatism has in its basis an allergic character of the disease.