Evaluation of the treatment effectiveness in patients with stage IIB–IIIB ovarian cancer

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Abstract

BACKGROUND: The relevance of the study is due to the urgent problem of assessing therapy effectiveness for stage IIB–IIIB ovarian cancer.

AIM: Study of patients' survival rates after surgical treatment of various forms of stages IIB–IIIB of ovarian cancer depending on a number of clinical and morphological factors.

MATERIAL AND METHODS: The material for the study was long-term observations of patients who received treatment from 2004 to 2021 at the Primorsky Regional Oncology Dispensary, the source was the medical record of an inpatient (form 003/u). The group of patients with stage IIB–IIIB ovarian cancer consisted of 107 patients, average age 50.7±11.5 years. Of these, 43 (40.2%) were women with stage IIB, 46 (43.0%) patients with stage IIIA, 3 (2.8%) patients with stage IIIA2, 15 (14.0%) patients with stage IIIB. Overall survival and progression-free survival were assessed. Statistical methods included survival analysis using the Kaplan–Meier method with the construction of survival curves, medians and standard errors of survival time, and comparison of survival between groups of patients using the log-rank test.

RESULTS: In patients with low-grade serous carcinoma, the five-year progression-free survival rate was higher than in patients with high-grade serous carcinoma (71.1±13.5 and 39.5±7.7%, respectively; p <0.01). Primary surgical treatment performed in gynecological hospitals reduced the median life expectancy and five-year survival rate by 150.0 months and 25.9% (p <0.01; RR=3.4; 95% CI=1.2–9.4). Interval cytoreduction reduced the median time to progression and five-year progression-free survival in patients with stage IIB–IIIB ovarian cancer (53.0±35.2 months and 43.7±16.5%) compared with patients underwent primary surgery (70.0±37.5 months and 57.3±6.0%). The five-year survival rate was higher in patients receiving a combination of platinum and taxanes — 94.7±5.1% (p <0.01; HR=0.2; 95% CI=0.05–0.5).

CONCLUSION: In patients with stage IIB–IIIB ovarian cancer, factors such as primary surgical treatment performed in specialized gynecological oncology hospitals and adjuvant chemotherapy with platinum drugs in combination with taxane agents statistically significantly increase survival.

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About the authors

Varvara N. Zhurman

Primorsky Regional Oncology Center; Pacific State Medical University

Author for correspondence.
Email: varvara2007@yandex.ru
ORCID iD: 0000-0002-6927-3336
SPIN-code: 1781-0007

MD, Cand. Sci. (Med.), Oncologist; Assistant, Depart. of Obstetrics and Gynecology

Russian Federation, Vladivostok; Vladivostok

References

  1. Stewart C, Ralyea C, Lockwood S. Ovarian cancer: An integrated review. Semin Oncol Nurs. 2019;35(2):151–156. doi: 10.1016/j.sonicn.2019.02.001
  2. Stages of ovarian cancer: international classification. Available from: https://www.oncomedic.org Accessed: Jan 5, 2024. (In Russ.)
  3. O'Shea AS. Clinical staging of ovarian cancer. Methods Mol Biol. 2022;2424:3–10. doi: 10.1007/978-1-0716-1956-8_1
  4. Faber MT, Horsbøl TA, Baandrup L. Trends in survival of epithelial ovarian/tubal cancer by histology and socioeconomic status in Denmark 1996–2017. Gynecol Oncol. 2022;164(1):98–104. doi: 10.1016/j.gino.2021.10.091
  5. Sekerskaya MN, Nikoghosyan SO, Kuznetsov VV, Shevchuk AS, Tamrazov RI, Aliev VA. Long-term outcomes of surgical treatment of common ovarian cancer at the stage of primary debulking. Pelvic Surgery and Oncology. 2019;(3):46–53. (In Russ.) doi: 10.17650/2686-9594-2019-9-3-46-53
  6. Ministry of Health of the Russian Federation. Clinical recommendations. Ovarian cancer, fallopian tube cancer, primary peritoneal cancer — 2020–2021–2022 (31.01.2023). Available from: http://disuria.ru/_ld/13/1326_kr20C48C56C57MZ.pdf Accessed: Feb 17, 2024.
  7. Washington CJ, Karanth SD, Wheeler M. Racial and socioeconomic disparities in survival among women with advanced-stage ovarian cancer who received systemic therapy. Cancer Causes Control. 2023;24:487–496. doi: 10.1007/s10552-023-01810-y
  8. Maslentseva NYu. Cancer incidence as an indicator of socio-economic problems. Aktual'nye problemy gumanitarnykh i estestvennykh nauk. 2015;(5-2):263–266. (In Russ.) EDN: TVPDVZ
  9. Rumyantsev AA, Tjulandina AS, Pokataev IA, Tjulandin SA. Controversies in surgical treatment of advanced ovarian cancer. Malignant Tumours. 2017;7(3):13–22. (In Russ.) doi: 10.18027/2224-5057-2017-7-3-13-22
  10. Gockley A, Melamed A, Bregar AJ, Clemmer JT, Birrer M, Schorge JO, Del Carmen MG, Rauh-Hain JA. Outcomes of women with high-grade and low-grade advanced-stage serous epithelial ovarian cancer. Obstet Gynecol. 2017;129(3):439–447. doi: doi: 10.1097/AOG.0000000000001867
  11. Ayhan A, Ozkan NT, Sarı ME, Celik H, Dede M, Akbayır Ö, Güngördük K, Şahin H, Haberal A, Güngör T, Arvas M, Meydanlı MM. Impact of lymph node ratio on survival in stage III ovarian high-grade serous cancer: A Turkish Gynecologic Oncology Group study. J Gynecol Oncol. 2018;29(1):e12. doi: 10.3802/jgo.2018.29.e12
  12. Engelen MJ, Kos HE, Willemse PH, Aalders JG, de Vries EG, Schaapveld M, Otter R, van der Zee AG. Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma. Cancer. 2006;106(3):589–598. doi: 10.1002/cncr.21616
  13. Ledermann JA, Raja FA, Fotopoulou C, Gonzalez-Martin A, Colombo N, Sessa C. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24:24–32. doi: 10.1093/annonc/mdt333
  14. Ghisoni E, Katsaros D, Maggiorotto F. A predictive score for optimal cytoreduction at interval debulking surgery in epithelial ovarian cancer: A two-centers experience. Research. 2018;11(1):42. doi: 10.1186/s13048-018-0415-y
  15. Fagotti A, Ferrandina G, Vizzielli G, Fanfani F, Salotti V, Chiantera V, Costantini B, Margariti PA. Phase III randomised clinical trial comparing primary surgery versus neoadjuvant chemotherapy in advanced epithelial ovarian cancer with high tumour load (SCORPION trial): Final analysis of peri-operative outcome. Eur J Cancer. 2016;59:22–33. doi: 10.1016/j.ejca.2016.01.017
  16. Gorodnova TV, Kotiv HB, Petrik SV, Sokolenko AP, Ivantsov AO, Guseinov KD, Ibragimov ZN, Meshkova IE, Nekrasova EA, Sidoruk AA, Smirnova OA, Bondarev NE, Lavrinovich OE, Mikaya NA, Ulrikh EA, Urmancheeva AF, Imyanitov EN, Karachun AM, Belyaev AM, Berlev IV. Cytoreductive surgery for ovarian cancer: a review of literature and analysis of the experience of the clinic for thirteen years. Voprosy onkologii. 2018;(3):353–368. (In Russ.) EDN: XWBIBF

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2. Fig. 1. Overall survival and progression-free survival of patients with stage IIB–IIIB ovarian cancer (Kaplan–Meier method)

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3. Fig. 2. Overall survival and progression-free survival of patients with stage IIB–IIIB ovarian cancer depending on histological type (Kaplan–Meier method)

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4. Fig. 3. Overall survival and progression-free survival of patients with stage IIB–IIIB ovarian cancer depending on the site of surgery (Kaplan–Meier method); ССОП — specialized gynecological oncology hospital; СГП — gynecological hospital

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5. Fig. 4. Overall survival and progression-free survival of patients with stage IIB–IIIB ovarian cancer depending on the type of surgery (Kaplan–Meier method)

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6. Fig. 5. Overall survival and progression-free survival of patients with stage IIB–IIIB ovarian cancer depending on adjuvant chemotherapy (I-line) (Kaplan–Meier method); РС/ТС + bev — platinum drugs in combination with taxanes and bevacizumab

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