Lateral differences of breast cancer proliferative activity (KI-67)
- Authors: Dmitrenko AP1
-
Affiliations:
- Oncology Center
- Issue: Vol 97, No 4 (2016)
- Pages: 550-555
- Section: Theoretical and clinical medicine
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/5602
- DOI: https://doi.org/10.17750/KMJ2015-550
- ID: 5602
Cite item
Full Text
Abstract
Aim. To determine lateral differences of breast cancer proliferative activity Ki-67.
Methods. According to immunohistochemical study protocols analysis of material of 500 patients with breast cancer was conducted. In primary tumors estrogen and progesterone receptors expression, Ki-67, C-erbB-2 was studied.
Results.Using two-way analysis of variance, it was found that Ki-67 index was significantly influenced by both side of the tumor lesion (p=0.009) and age of patients (p=0.0002). A higher Ki-67 corresponded to right-sided cancer localization. Statistically significant age differences of Ki-67 index are marked only in right-sided cancer (p
Conclusion. Statistically significant difference of Ki-67 index in right- and left-sided breast cancer was found, significantly higher Ki-67 was detected in the right-sided tumors, Ki-67 are present only in patients before 60 years.
About the authors
A P Dmitrenko
Oncology Center
Author for correspondence.
Email: Alex_Dmitrenko@mail.ru
References
- Аарелейд Т.П., Хинт Э.К. О преобладании опухолей в левой молочной железе. Вопр. онкол. 1987; 33 (5): 37-42.
- Ерендеева Л.Э., Завьялова M.B., Слонимская Е.М., Перельмутер В.М. Влияние функциональной асимметрии на прогноз рака молочной железы. Бюлл. сиб. мед. 2002 (1): 36-39.
- Лемешко Б.Ю., Лемешко С.Б., Постовалов С.Н. и др. Статистический анализ данных, моделирование и исследование вероятностных закономерностей. Компьютерный подход. Новосибирск: НГТУ. 2011; 888 с.
- Порошенко А.Б. О природе дефицита противораковой устойчивости организма. В кн.: Способы и механизмы повышения противоопухолевой защиты в онкологии. Сборник научных трудов РНИОИ под ред. Ю.С. Сидоренко. М. 1993; 211-257.
- Dabbs D. Diagnostic immunohistochemistry (2nd ed.). Philadelphia, Churchill Livingstone: Elsevier. 2006; 828 p.
- Dowsett M., A’Hern R., Salter J. et al. Who would have thought a single Ki67 measurement would predict long-term outcome? Breast Cancer Res. 2009; 11 (3): 515. http://dx.doi.org/10.1186/bcr2434
- Hartveit F., Tangen M., Hartveit E. Side and survival in breast cancer. Oncology. 1984; 41 (3): 149-154. http://dx.doi.org/10.1159/000225812
- Mandard A.M., Denoux Y., Herlin P. et al. Prognostic value of DNA cytometry in 281 premenopausal patients with lymph node negative breast carcinoma randomized in a control trial: multivariate analysis with Ki-67 index, mitotic count, and microvessel density. Cancer. 2000; 89: 1748-1757. http://dx.doi.org/10.1002/1097-0142(20001015)89:8<1748::AID-CNCR15>3.0.CO;2-E
- Melnik Y., Slater P.E., Steinitz R. et al. Breast cancer in Israel: laterality and survival. J. Cancer Res. Clin. Oncol. 1979; 95 (3): 291-293. http://dx.doi.org/10.1007/BF00410651
- Nouh M., Ismail H., Aliel-Din N. et al. Lymph node metastasis in breast carcinoma: clinicopathologic correlations in 3747 patients. J. Egyptian Nat. Cancer Inst. 2004; 16 (1): 50-56.
- Perkins C.I., Hotes J., Kohler B.A. et al. Association between breast cancer laterality and tumor location, United States, 1994-1998. Cancer Causes Control. 2004; 15 (7): 637-645. http://dx.doi.org/10.1023/B:CACO.0000036171.44162.5f
- Trihia H., Murray S., Price K. et al. Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors - a surrogate marker? Cancer. 2003; 1 (97(5)): 1321-1331. http://dx.doi.org/10.1002/cncr.11188
- Tulinius H., Sigvaldason H., Olafsdуttir G. Left and right sided breast cancer. Pathol. Res. Pract. 1990; 186 (1): 92-94. http://dx.doi.org/10.1016/S0344-0338(11)81015-0
- Weiss H.A., Devesa S.S., Brinton L.A. Laterality of breast cancer in the United States. Cancer Causes Control. 1996; 7 (5): 539-543. http://dx.doi.org/10.1007/BF00051887
- Yerushalmi R., Woods R., Ravdin P.M. et al. Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol. 2010; 11 (2): 174-183. http://dx.doi.org/10.1016/S1470-2045(09)70262-1
Supplementary files
