Evaluation of the relationship between concentration of endothelin-1 and magnesium in the blood and the severity of ischemic heart disease

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Abstract

Aim. To study the relationship between concentrations of endothelin-1 and magnesium in blood depending on functional class and old myocardial infarction in patients with stable angina.

Methods. The study included 58 patients with ischemic heart disease, II and III functional class stable angina. 19 of these patients suffered a myocardial infarction in the past. The control group consisted of 25 healthy volunteers. Endothelin-1 level in blood serum was determined by enzyme immunoassay, the concentration of magnesium by colorimetric method.

Results.Endothelin-1 level in the general group of patients with stable angina was 1.28±0.23 fmol/ml and was significantly higher than that of control group (0.52±0.13 fmol/ml, p

Conclusion. In patients with II-III functional class stable angina statistically significant increase in level of endothelin-1 and a decrease in the concentration of magnesium in blood serum compared with the control group was revealed; a negative correlation between endothelin-1 and magnesium levels in the blood, which is characterized by increasing the degree of correlation depending on the severity of the ischemic heart disease clinical form was established.

About the authors

R F Abdullayev

Scientific-Research Institute of Cardiology named after J. Abdullayev

Author for correspondence.
Email: gulnazdadashova@mail.ru

A B Bakhshaliev

Scientific-Research Institute of Cardiology named after J. Abdullayev

Email: gulnazdadashova@mail.ru

A D Gulieva

Scientific-Research Institute of Cardiology named after J. Abdullayev

Email: gulnazdadashova@mail.ru

R R Huseynzade

Azerbaijan Medical University

Email: gulnazdadashova@mail.ru

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© 2016 Abdullayev R.F., Bakhshaliev A.B., Gulieva A.D., Huseynzade R.R.

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