Problems and prospects of studying hemorrhagic fever with renal syndrome in the Republic of Tatarstan

Cover Page
Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


The paper presents the history of the study of hemorrhagic fever with renal syndrome (HFRS) at the Kazan Research Institute of Epidemiology and Microbiology from the beginning of the 50s to the present. The accumula­ted information allows to draw up general conceptions about the main source of infection, the biological structure of natural foci of infection, nosoarea and the main clinical forms of the disease, the nature and seasonality of the disease, the sex and age composition of patients, and the types of natural foci of HFRS. The stages of improving the methods of laboratory diagnosis of HFRS, development of a specific immunoglobulin against the serum of the Puumala virus are described. A significant contribution to the study of HFRS was the landscape-epidemiological ranking of the territory of the Republic of Tatarstan and the Middle Volga endemic for HFRS, with the identification of zones of special risk of human infection and the main factors that form them. At present, a reference center for monitoring HFRS has been created based on the Kazan Research Institute of Epidemiology and Microbiology, and the study of the properties of HFRS pathogens at the current molecular-genetic level continues.


Full Text

Restricted Access

About the authors

V A Boyko

Kazan Scientific Research Institute of Epidemiology and Microbiology

Email: tatasav777@mail.ru

Russian Federation, Kazan, Russia

T A Savitskaya

Kazan Scientific Research Institute of Epidemiology and Microbiology

Author for correspondence.
Email: tatasav777@mail.ru

Russian Federation, Kazan, Russia

V A Trifonov

Kazan Scientific Research Institute of Epidemiology and Microbiology; Kazan State Medical Academy

Email: tatasav777@mail.ru

Russian Federation, Kazan, Russia; Kazan, Russia

I V Serova

Kazan Scientific Research Institute of Epidemiology and Microbiology

Email: tatasav777@mail.ru

Russian Federation, Kazan, Russia

G Sh Isaeva

Kazan Scientific Research Institute of Epidemiology and Microbiology; Kazan State Medical University

Email: tatasav777@mail.ru

Russian Federation, Kazan, Russia; Kazan, Russia

References

  1. Ткаченко Е.А., Ишмухаметов А.А. История изу­чения этиологии геморрагической лихорадки с почечным синдромом. Мед. совет. 2017; (4): 86–92. [­Tkachenko E.A., Ishmukhametov A.A. History of the study of hemorrhagic fever etiology with renal syndrome. Meditsinskiy sovet. 2017; (4): 86–92. (In Russ.)] doi: 10.21518/2079-701X-2017-4-86-92.
  2. Churilov A.V. Clinic of the so-called nephroso-nephritis. Klinicheskaya meditsina. 1941; (8): 78–82. (In Russ.)
  3. Kazbintsev L.I. Clinic of the so-called acute infectious nephritis. Terapevticheskiy arkhiv. 1941; (3): 341–346. (In Russ.)
  4. Dunaevskiy M.I. The problem of hemorrhagic nephroso-nephritis. Report 2. Changes in blood and urine in hemorrhagic nephrosis-nephritis and their importance for diagnosis and pathogenesis. Arkhiv biologiches­kikh nauk. 1941; 62 (5): 53. (In Russ.)
  5. Smorodintsev A.A., Al'tshuller I.S., Dunaevskiy M.I. et al. Etiologiya i klinika gemorragicheskogo nefrozo-nefrita. (Etiology and clinic of hemorrhagic nephroso-nephritis.) М.: Medgiz. 1944; 47 р. (In Russ.)
  6. Kitano M. Purpura haemorrhagica epidemica. J. Orient. Med. 1940; Febr.: 192–209.
  7. Vereta L.A., Vladimirova T.P., Koval'skiy G.K. Experience in specific prevention of HFRS. Zhurnal mikrobiologii. 1968; (5): 3–8. (In Russ.)
  8. Boj­ko V.A., Trifonov V.A., Potapov V.S. Prirodnye ochagi zooantroponozov transformirovannyh landshaftov Respubliki Tatarstan vo vtoroj polovine XX veka. (Natural foci of zooanthroponoses in the transformed landscapes of the Republic of Tatarstan in the second half of the 20th century.) Kazan': Novoe znanie. 2001; 120 р. (In Russ.)
  9. Gemorragicheskaya lihoradka s pochechnym sindromom (GLPS) v Srednem Povolzh'e i Predural'e. (Hemorrhagic fever with renal syndrome (HFRS) in the Middle Volga region and the Urals.) Leningrad. 1980; 135 р. (In Russ.)
  10. Lee H.W., Lee P.W., Johnson K.M. Isolation of the etiologic agent of Korean hemorrhagic fever. J. Infect. Dis. 1978; 137: 298–308. doi: 10.1093/infdis/137.3.298.
  11. Part 1. Etio­logy, laboratory diagnostics, epidemiology, prevention. In: Gemorragicheskaya lihoradka s pochechnym sindromom (GLPS) v Srednem Povolzh'e. (Hemorrhagic fever with renal syndrome (HFRS) in the Middle Volga region.) Kazan': KIB KFAN SSSR. 1989; 128 р. (In Russ.)
  12. Boyko V.A., Trifonov V.A., Potapov V.S. Prirodno-ochagovye infekcii v lesah goroda Kazani i Prikazanskogo regiona. (Natural focal infections in the forests of the city of Kazan and the Prikazan region.) Kazan': Medicina. 2011; 110 р. (In Russ.)
  13. Boyko V.A., Trifonov V.A., Reshetnikova I.D. Monitoring dominiruyushchih prirodno-ochagovyh infekcij i opyt ocenki potencial'nogo riska zarazheniya naseleniya v landshaftnyh podzonah Tatarstana. (Monito­ring of dominant natural focal infections and experience in assessing the potential risk of infection of the population in the landscape subzones of Tatarstan.) Kazan'. 2017; 83 р. (In Russ.)
  14. Savitskaya T.A., Trifonov V.A., Agafonova E.V. et al. Serological monitoring in the epidemiological surveillance system of feral herd infections in the Republic of Tatarstan. Epidemiologiya i infektsionnye bolezni. Aktual'nye voprosy. 2018; (1): 15–20. (In Russ.)
  15. Povalishina T.P., Dza­gurov S.G., Yankovskiy A.K. Epidemiological characteristics of foci of hemorrhagic fever with renal syndrome (HFRS) in the European part of the RSFSR. Materialy. problemnoy komissii IPiVE AMN SSSR. 1967; 2: 195–197. (In Russ.)
  16. Savel'eva N.A., Vostrikov L.A. Some issues of the epidemiology of hemorrhagic fever with renal syndrome in the Khabarovsk Krai and the tactics of preventive measures. Trudy IPiVE AMN SSSR. 1965; 7: 95–96. (In Russ.)
  17. Simonov S.B., Slonova R.A., Simonov P.S. Ecologo-epidemiological zoning of Pri­morye region in connection with hantavirus infection. Vestnik DVO RAN. 2008; (3): 58–64. (In Russ.)
  18. Ermolaev O.P., Igonin M.E., Bub­nov A.Yu., Pavlova S.V. Landshafty Respubliki Tatarstan. Kazan': Slovo. 2007; 410 р. (In Russ.)
  19. Trifonov V.A., Davidyuk Yu.N., Isaeva G.Sh. et al. Study of the infection of the red vole by the Puumala virus in natural foci of HFRS in Tatarstan. Dnevnik Kazanskoy meditsinskoy shkoly. 2018; (4): 36–39. (In Russ.)
  20. Trifonov V.A., Boiko V.A., Savitskaya T.A. Methodological approaches to monitoring of the population morbidity with natural focal infections in large cities of the Republic of Tatarstan. Meditsinskiy al'manakh. 2017; (4): 102–106. (In Russ.)
  21. Savitskaya T.A., Trifonov V.A., Isaeva G.Sh. et al. Review of the current epidemiological situation on the incidence of hemorrhagic fever with renal syndrome in the world and forecast of the incidence for the territory of the Russian Fe­deration in 2019. Problemy osobo opasnyh infektsiy. 2019; (2): 30–36. (In Russ.) doi: 10.21055/0370-1069-2019-2-30-36.

Supplementary files

Supplementary Files Action
1.
Рис. 1. Тимофей Антонович Башкирёв, директор Казанского научно-исследовательского института эпидемиологии и микробиологии в 1970–1983 гг., впервые стал проводить исследования в области этиологии, диагностики, эпидемиологии и профилактики геморрагической лихорадки с почечным синдромом

Download (21KB) Indexing metadata
2.
Рис. 2. Камеральная обработка зоологического материала: м.н.с. В.Г. Ивлиев, сентябрь 1976 г., Альметьевский район ТАССР

Download (39KB) Indexing metadata
3.
Рис. 3. Производство иммуноглобулина против геморрагической лихорадки с почечным синдромом для практического здравоохранения

Download (78KB) Indexing metadata
4.
Рис. 4. Погрузка на ГАЗ-69 соломы для устройства гнездилищ мелким лесным млекопитающим в зимний период 1976 г. Справа — заведующий лабораторией природно-очаговых инфекций с.н.с. В.А. Бойко

Download (25KB) Indexing metadata
5.
Рис. 5. Устройство стожка над гнездилищем. Справа — заведующий лабораторией природно-очаговых инфекций с.н.с. В.А. Бойко (1976 г.)

Download (38KB) Indexing metadata
6.
Рис. 6. Снятие снегового покрова м.н.с. В.Г. Ивлиевым со стожка и последующие манипуляции по отлову зверьков и изъятие коллективного гнезда с эктопаразитами (1976 г.)

Download (19KB) Indexing metadata
7.
Рис. 7. Сотрудники референс-центра по мониторингу за геморрагической лихорадкой с почечным синдромом. Слева направо: врач-эпидемиолог И.В. Серова, руководитель референс-центра Т.А. Савицкая, в.н.с. В.А. Трифонов (июнь 2019 г.)

Download (33KB) Indexing metadata

Statistics

Views

Abstract - 39

PDF (Russian) - 1

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions


© 2020 Boyko V.A., Savitskaya T.A., Trifonov V.A., Serova I.V., Isaeva G.S.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.





This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies