The intensity of oxidative stress and systemic inflammation in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease
- Authors: Faletrova S.V.1, Uryasev O.M.1, Belskikh E.S.1, Berstneva S.V.1, Korshunova L.V.1
-
Affiliations:
- Ryazan State Medical University named after I.P. Pavlov
- Issue: Vol 104, No 2 (2023)
- Pages: 165-175
- Section: Theoretical and clinical medicine
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/104535
- DOI: https://doi.org/10.17816/KMJ104535
Cite item
Abstract
Background. Chronic obstructive pulmonary disease and bronchial asthma, when combined in one patient, are characterized by a low level of control. Excess weight aggravates the course of obstructive diseases. The study of the features of this syntropy will improve the effectiveness of therapeutic measures.
Aim. The study of the level of cytokines and carbonylated proteins in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease with overweight and normal weight during an exacerbation.
Material and methods. The study included 136 people: the first group — a combination of bronchial asthma and chronic obstructive pulmonary disease (n=30), the second — bronchial asthma (n=36), the third — chronic obstructive pulmonary disease (n=29), the fourth — volunteers without respiratory diseases (n=41). Each group was divided into two subgroups depending on the body mass index (less than 25 kg/m2 or 25 kg/m2 and more). The concentrations of interleukins-6 and -8, tumor necrosis factor α in blood plasma were determined by enzyme immunoassay. The level of carbonylated plasma proteins was assessed spectrophotometrically. Statistical processing was performed in the Statistica 10.0 program using nonparametric criteria. The correlation of the studied parameters was assessed using the Spearman coefficient.
Results. In patients with a combination of bronchial asthma and chronic obstructive pulmonary disease, statistically significant positive correlations between the levels of interleukins-6 and -8, tumor necrosis factor α and carbonylated proteins were found — 0.51, 0.59 and 0.55, respectively (p <0.05). Patients of the first group with overweight differed by 37.5% in higher levels of interleukin-6 compared with patients with body mass index <25 kg/m2.
Conclusion. The intensity of systemic inflammation in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease during exacerbation correlates with the intensity of oxidative damage.
Keywords
Full Text

About the authors
Svetlana V. Faletrova
Ryazan State Medical University named after I.P. Pavlov
Author for correspondence.
Email: faletrova@yandex.ru
ORCID iD: 0000-0003-1532-0827
SPIN-code: 1427-8316
Scopus Author ID: 57218911623
ResearcherId: AEY-8072-2022
Assistant, Depart. of Faculty Therapy named after Professor V.Y. Garmash
Oleg M. Uryasev
Ryazan State Medical University named after I.P. Pavlov
Email: Uryasev08@yandex.ru
ORCID iD: 0000-0001-8693-4696
SPIN-code: 7903-4609
Scopus Author ID: 57195313767
ResearcherId: S-6270-2016
M.D., D. Sci. (Med.), Prof., Head of Depart., Depart. of Faculty Therapy named after Professor V.Y. Garmash
Russian Federation, Ryazan, RussiaEduard S. Belskikh
Ryazan State Medical University named after I.P. Pavlov
Email: ed.bels@yandex.ru
ORCID iD: 0000-0003-1803-0542
SPIN-code: 9350-9360
Scopus Author ID: 57195313786
ResearcherId: A-7202-2019
M.D., Cand. Sci. (Med.), Assistant, Depart. of Faculty Therapy named after Professor V.Y. Garmash
Svetlana V. Berstneva
Ryazan State Medical University named after I.P. Pavlov
Email: berst.ru@mail.ru
ORCID iD: 0000-0002-3141-4199
SPIN-code: 6722-3203
Scopus Author ID: 57192170841
ResearcherId: B-9814-2018
M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Faculty Therapy named after Professor V.Y. Garmash
Ludmila V. Korshunova
Ryazan State Medical University named after I.P. Pavlov
Email: post_luda@mail.ru
ORCID iD: 0000-0003-0945-0772
SPIN-code: 4694-3605
M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Faculty Therapy named after Professor V.Y. Garmash
Russian Federation, Ryazan, RussiaReferences
- Mekov E, Nuñez A, Sin DD, Ichinose M, Rhee CK, Maselli DJ, Coté A, Suppli Ulrik C, Maltais F, Anzueto A, Miravitlles M. Update on asthma-COPD overlap (ACO): A narrative review. Int J COPD. 2021;16:1783–1799. doi: 10.2147/COPD.S312560.
- Hosseini M, Almasi-Hashiani A, Sepidarkish M. Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis. Respir Res. 2019;20(1):229. doi: 10.1186/s12931-019-1198-4.
- Miethe S, Karsonova A, Karaulov A, Renz H. Obesity and asthma. J Allergy Clin Immunol. 2020;146(4):685–693. doi: 10.1016/j.jaci.2020.08.011.
- Faletrova SV, Korshunova LV, Belskikh ES. Clinical and functional features of chronic obstructive lung disease in patients with obesity. Eruditio Juvenium. 2018;6(3):439–447. (In Russ.) doi: 10.23888/HMJ201863439-447.
- Drapkina OM, Avdeev SN, Budnevsky AV, Ovsyannikov ES, Kontsevaya AV, Drobysheva ES. Nutrition status and obesity paradox in chronic obstructive pulmonary disease. Voprosy pitaniya. 2021;90(6):42–49. (In Russ.) doi: 10.33029/0042-8833-2021-90-6-42-49.
- Ovsyannikov ES, Budnevsky AV, Shkatova YS. Assessment of effectiveness of training of respiratory musculature in patients with chronic obstructive pulmonary disease and obesity. IP Pavlov Russian Medical Biological Herald. 2019;27(3):367–374. (In Russ.) doi: 10.23888/PAVLOVJ2019273367-374.
- Peltola L, Pätsi H, Harju T. COPD Comorbidities Predict High Mortality — Asthma-COPD-Overlap Has Better Prognosis. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2020;17(4):366–372. doi: 10.1080/15412555.2020.1783647.
- Gava G, Núñez A, Esquinas C, Sarasate M, Loeb E, Pirina P, Miravitlles M, Barrecheguren M. Analysis of blood biomarkers in patients with Chronic Obstructive Pulmonary Disease (COPD) and with Asthma-COPD Overlap (ACO). COPD: Journal of Chronic Obstructive Pulmonary Disease. 2020;17(3):306–310. doi: 10.1080/15412555.2020.1761314.
- Ghosh N, Choudhury P, Kaushik SR, Arya R, Nanda R, Bhattacharyya P, Roychowdhury S, Banerjee R, Chaudhury K. Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO). Respir Res. 2020;21(1):126. doi: 10.1186/s12931-020-01390-4.
- Marwick JA, Ito K, Adcock IM, Kirkham PA. Oxidative stress and steroid resistance in asthma and COPD: Pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opin Ther Targets. 2007;11(6):745–755. doi: 10.1517/14728222.11.6.745.
- Sies H, Berndt C, Jones DP. Oxidative stress. Annu Rev Biochem. 2017;86:715–748. doi: 10.1146/annurev-biochem-061516-045037.
- Nikolova G, Ilieva V, Karamalakova Y, Zheleva A, Gadjeva V. Comparative study of oxidative status in blood of asthmatic patients. Comp Clin Pathol. 2018;27:1057–1063. doi: 10.1007/s00580-018-2701-x.
- Belskikh ES, Uryasev OM, Zvyagina VI, Faletrova SV. Development of secondary mitochondrial dysfunction of blood mononuclear leukocytes in patients with chronic obstructive pulmonary disease and chronic bronchitis. Kazan Medical Journal. 2018;99(5):741–747. (In Russ.) doi: 10.17816/KMJ2018-741.
- Tikhova GP. Planning clinical research. question #1: how to calculate enough sample volume? Regional Anesthesia and Acute Pain Management. 2014;(3):57–63. (In Russ.)
- Fomina MA, Abalenikhina YuV. Okislitelʹnaya modifikatsiya belkov tkaney pri izmenenii sinteza oksida azota. (Oxidative modification of tissue proteins by changing the synthesis of nitric oxide.) Moscow: GEOTAR-Media; 2018. 192 p. (In Russ.)
- Kubysheva N, Boldina M, Eliseeva T, Soodaeva S, Klimanov I, Khaletskaya A, Bayrasheva V, Solovyev V, Villa-Vargas LA, Ramírez-Salinas MA, Salinas-Rosales M, Ovsyannikov DY, Batyrshin I. Relationship of serum levels of IL-17, IL-18, TNF-α, and lung function parameters in patients with COPD, asthma-COPD overlap, and bronchial asthma. Mediators Inflamm. 2020;12:4652898. doi: 10.1155/2020/4652898.
- Colombo G, Aldini G, Orioli M, Giustarini D, Gornati R, Rossi R, Colombo R, Carini M, Milzani A, Dalle-Donne I. Water-Soluble alpha, beta-unsaturated aldehydes of cigarette smoke induce carbonylation of human serum albumin. Antioxid Redox Signal. 2010;12(3):349–364. doi: 10.1089/ars.2009.2806.
- Scott HA, Wood LG, Gibson PG. Role of obesity in asthma: mechanisms and management strategies. Curr Allergy Asthma Rep 2017;17(8):53. doi: 10.1007/s11882-017-0719-9.
- Sindhu S, Thomas R, Shihab P, Sriraman D, Behbehani K, Ahmad R. Obesity is a positive modulator of IL-6R and IL-6 expression in the subcutaneous adipose tissue: Significance for metabolic inflammation. PLoS One. 2015;10(7):e0133494. doi: 10.1371/journal.pone.0133494.
- Budnevsky AV, Malysh EY, Ovsyannikov ES, Drobysheva ES. Asthma and metabolic syndrome: Clinical and pathogenetic relationships. Therapeutic archive. 2015;87(10):110–114. (In Russ.) doi: 10.17116/TERARKH20158710110-114.
- Karczewski J, Śledzińska E, Baturo A, Jończyk I, Maleszko A, Samborski P, Begier-Krasińska B, Dobrowolska A. Obesity and inflammation. Eur Cytokine Netw. 2018;29(3):83–94. doi: 10.1684/ecn.2018.0415.
- Herrero-Cervera A, Soehnlein O, Kenne E. Neutrophils in chronic inflammatory diseases. Cell Mol Immunol. 2022;19(2):177–191. doi: 10.1038/s41423-021-00832-3.
Supplementary files
