Stimulation of Regenerative Processes in Nonhealing Anal Canal Wounds Using Splenodimexide: A Randomized Clinical Study



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Abstract

BACKGROUND: One of the key challenges in modern coloproctology and surgery is the prolonged healing time of wounds following hemorrhoidectomy and anal fissure excision, which is often due to postoperative complications.

AIM: To evaluate the effect of splenodimexide on cleansing and regeneration processes in nonhealing anorectal wounds.

METHODS: This study analyzed the treatment outcomes of 64 patients who were rehospitalized on days 41–60 following hemorrhoidectomy or anal fissure excision due to the persistence of chronic nonhealing anorectal wounds. The main group comprised 34 (53%) patients (19 post-hemorrhoidectomy and 15 post-fissure excision), whereas the control group included 30 (47%) patients (16 post-hemorrhoidectomy and 14 post-fissure excision). Both groups received standard comprehensive therapy, including the local treatment of nonhealing anal canal wounds. In the main group, splenodimexide with dioxidine was applied, which was prepared by mixing xenogeneic spleen homogenate with dimexide and applying the mixture to a gauze dressing at 1 mL per 1 cm2 of wound surface area. In the control group, standard dressing agents were used. Statistical analysis was performed using Student’s t-test and χ2-test, and correlations were evaluated using Pearson’s r. Data were processed using Statistica 6.0. The critical level of statistical significance was set at p = 0.05.

RESULTS: Patients in the main group showed more intensive regenerative processes, as demonstrated by the faster decrease of inflammation and earlier epithelialization (p = 0.055). The mean healing time of nonhealing wounds decreased by 9 days (27.6%) after hemorrhoidectomy (p = 0.055) and by 8.5 days (24.5%) after anal fissure excision (p = 0.033).

CONCLUSION: The topical use of splenodimexide as part of comprehensive therapy for nonhealing anorectal wounds decreases inflammation, enhances reparative processes, and shortens wound-healing time.

About the authors

Magomed A. Aliyev

Dagestan State Medical University

Author for correspondence.
Email: mfar2002@mail.ru
ORCID iD: 0009-0006-1649-6583

MD, Dr. Sci. (Medicine), assistant professor, head, depart. of surgical diseases of dentistry and pediatric faculties

Russian Federation, Makhachkala

Khangerye M. Abdulmajidov

City Clinical Hospital

Email: khan0567@yandex.ru
ORCID iD: 0009-0000-9470-6351

assistant, depart. of surgical diseases of dental, pediatric and preventive medicine faculties; deputy chief physician

Makhachkala

Shamil A. Abdullaev

City Clinical Hospital

Email: Proktolog1975@mail.ru
ORCID iD: 0009-0003-6568-1521

MD, Cand. Sci. (Medicine), head, Republican department of colorectology

Russian Federation, Makhachkala

Sahruduin Yu. Safarov

Dagestan State Medical University

Email: Safarov39@mail.ru
ORCID iD: 0009-0007-9068-9479

MD, Dr. Sci. (Medicine), professor, depart. of surgical diseases of pediatric, dental and preventive medicine faculties

Russian Federation, Makhachkala

Sapiyat R. Rabadanova

Dagestan State Medical University

Email: Dgmatrud@mail.ru
ORCID iD: 0009-0007-8608-0679
SPIN-code: 3271-6180

MD, Cand. Sci. (Medicine), assistant professor, surgical diseases of dental and paediatric faculties

Russian Federation, Makhachkala

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