The role of urogenital infection in the development of reproductive system disorders in minor children

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

BACKGROUND: Vaginitis and urinary tract infections are common diseases among minors suffering from reproductive system disorders.

AIM: To assess the state of vaginal microflora and features of neurohormonal status in adolescent patients with recurrent uro­genital inflammatory diseases.

MATERIAL AND METHODS: 130 teenage girls aged 16–18 years were examined, the following groups were identified: first — 34 patients with vaginitis and urinary tract infection; the second — 32 patients with urinary tract infection, the third — 34 patients with vaginitis without urinary tract infection, the fourth — 30 teenage girls without vaginitis and urinary tract infection. An assessment of vaginal microbiota and individual parameters of neurohormonal status was carried out. The distribution of variables was checked for normality using the Kolmogorov–Smirnov test; for a normal distribution, the Student t-test; for a non-normal distribution, the Mann–Whitney U test. The significance of differences in relative values was assessed using Fisher and χ2 tests. Results were considered statistically significant at p <0.05.

RESULTS: It was found that in patients of the first group, in comparison with girls from other groups, there were fewer lactobacilli colonies (3.79±0.19 genome equivalents/sample; p1–2=0.019, p1–3=0.012, p1–4=0.010), the relative indicator of biota was greater (0.81±0.12; p1–2=0.020; p1–3=0.011; p1–4=0.007). The growth of Candida spp. colonies >103 genome equivalents/sample was detected (82.4%; р1–2=0.021, р1–3=0.011, р1–4=0.002).There was an increase in the concentrations of cortisol (655.7±104.23 nmol/l; р1–3=0.021, р1–4=0.024, р1–2=0.032), adrenaline (14.5±3.12 nmol/l, р1–3=0.028, р1–4=0.030, р1–2=0.029), decrease in norepinephrine level (1.4±0.11 nmol/l, р1–3=0.021, р1–4=0.023, р1–2=0.020), menstrual cycle disorders (85.3%; p1–2=0.024, p1–3=0.019).

CONCLUSION: In adolescent girls with recurrent urogenital inflammatory diseases, dysbiotic changes in the vaginal microflora, increased levels of stress hormones, and reproductive system disorders were revealed.

Full Text

Restricted Access

About the authors

Yulia Yu. Chebotareva

Rostov State Medical University

Author for correspondence.
Email: chebotarevajulia@inbox.ru
ORCID iD: 0000-0001-9609-0917
SPIN-code: 5472-7767
Scopus Author ID: 57202232832

MD, Dr. Sci. (Med.), Prof., Depart. of Obstetrics and Gynecology No. 2

Russian Federation, Rostov-on-Don

Yuri A. Petrov

Rostov State Medical University

Email: mr.doktorpetrov@mail.ru
ORCID iD: 0000-0002-2348-8809
SPIN-code: 1582-0468

MD, Dr. Sci. (Med.), Prof., Head of Depart., Depart. of Obstetrics and Gynecology No. 2

Russian Federation, Rostov-on-Don

References

  1. Federal'naya sluzhba gosudarstvennoi statistiki. Rossiiskii statisticheskii ezhegodnik: statisticheskii sbornik. (Federal State Statistics Service. Russian statistical yearbook: statistical collection.) Moscow: Rosstat; 2021. 230 р. (In Russ.)
  2. Chebotareva YuYu, Petrov YuA. Detskaya i podrostkovaya ginekologiya. (Pediatric and adolescent gynecology.) Moscow: Medicinskaya kniga; 2022. 248 р. (In Russ.) EDN: FRDCRS
  3. Loveless M, Myint O. Vulvovaginitis — presentation of more common problems in pediatric and adolescent gynecology. Best Pract Res Clin Obstet Gynaecol. 2018;48:14–27. doi: 10.1016/j.bpobgyn.2017.08.014
  4. Zuckerman A, Romano M. Clinical recommendation: Vulvovaginitis. J Pediatr Adolesc Gynecol. 2016;29(6):673–679. doi: 10.1016/j.jpag.2016.08.002
  5. Lanis A, Talib HJ, Dodson N. Prepubertal and adolescent vulvovaginitis: What to do when a girl reports vaginal discharge. Pediatr Ann. 2020;49(4):e170–e175. doi: 10.3928/19382359-20200317-01
  6. Letifov GM, Chebotareva JuJu, Kolodjaschnaja EG. Special aspects of reproductive system and hormonal status development in adolescents girls with chronic pyelonephritis. Nephrology (Saint-Petersburg). 2014;18(5):59–62. (In Russ.) EDN: SQYMTP
  7. Kostoeva ZA, Chebotareva YuYu, Letifov GM, Imieva TB, Bogatyreva LN. Features of comorbid symptoms in vulvovaginitis in girls with urinary tract infections. Nephrology (Saint-Petersburg). 2021;25(1):90–95. (In Russ.) doi: 10.36485/1561-6274-2021-25-1-90-95
  8. Baka S, Demeridou S, Kaparos G, Tsoutsouras K, Touloumakos S, Dagre M, Meretaki S, Chasiakou A, Koumaki V, Tsakris A. Microbiological findings in prepubertal and pubertal girls with vulvovaginitis. Eur J Pediatr. 2022;181(12):4149–4155. doi: 10.1007/s00431-022-04631-4
  9. Chebotareva YuYu, Kostoeva ZA, Letifov GM. Interdisciplinary approach to solving the problem of bacterial vulvovaginitis in girls. Medical council. 2018;13:124–129. (In Russ.) doi: 10.21518/2079-701X-2018-13-124-129
  10. Letifov GM, Kostoeva ZA, Chebotareva YuYu, Grigoryan AA. Immunological aspects of the treatment of chronic vulvovaginitis in girls with urinary system infection. Russian Bulletin of Perinatology and Pediatrics. 2018;63(4):219. (In Russ.) EDN: XXRDRZ
  11. Kazakova AV, Uvarova EV, Spiridonova NV, Ovchinnikova AO. The role of hygiene practices in the formation of the vagina microbiocenosis girls with regard to the stage of sexual development. Pediatric and adolescent reproductive health. 2017;72(1):79–85. (In Russ.) EDN: YGWLIX
  12. Uvarova EV. Abnormal uterine bleeding of puberty. Pediatric and adolescent reproductive health. 2018;(1):64–91. (In Russ.) EDN: YTZDPR
  13. Mishina AI, Kazakova AV, Uvarova EV. Risk factors for abnormal uterine bleeding in pubertal girls, prognosis and prevention. Pediatric and adolescent reproductive health. 2022;18 (1):47–55. (In Russ.) doi: 10.33029/1816-2134-2022-18-1-47-55
  14. Salnikova IA, Uvarova EV, Khashchenko EP, Donnikov AE. Features of genitals microbiocenosis in girls with abnormal uterine bleeding. Pediatric and adolescent reproductive health. 2022;18(1):56–64. (In Russ.) doi: 10.33029/1816-2134-2022-18-1-56-64
  15. Yücel G, Kendirci M, Gül Ü. Menstrual characteristics and related problems in 9- to 18-year-old Turkish school girls. J Pediatr Adolesc Gynecol. 2018;31(4):350–355. doi: 10.1016/j.jpag.2018.03.002
  16. De Sanctis V, Rigon F, Bernasconi S, Bianchin L, Bona G, Bozzola M, Buzi F, De Sanctis C, Tonini G, Radetti G, Perissinotto E. Age at menarche and menstrual abnormalities in adolescence: does it matter? The evidence from a large survey among Italian secondary schoolgirls. Indian J Pediatr. 2019;86(1):34–41. doi: 10.1007/s12098-018-2822-x
  17. Uvarova EV, Komarova MV, Kazakova AV, Rustyanova DR, Trupakova AA, Kroider AS. Evaluation of the vaginal microbiota taking into account the stage of sexual development from the standpoint of biological diversity. Pediatric and adolescent reproductive health. 2022;18(2):48–57. (In Russ.) doi: 10.33029/1816-2134-2022-18-2-48-57
  18. Konopinski MK. Shannon diversity index: A call to replace the original Shannon’s formula with unbiased estimator in the population genetics studies. Peer J. 2020;8: e9391. doi: 10.7717/peerj.9391
  19. Uvarova EV, Artyukh YuA, Kazakova AV. The ratio of aerobic and anaerobic vaginal microflora in different periods of puberty. Modern problems of science and education. 2017;(1):124. (In Russ.) EDN: XXNDHF
  20. Trapkova AA, Mishina AI, Kazakova AV, Lineva OI, Uvarova EV. Risk factors for the development of vulvovaginal candidiasis in girls. Pediatric and adolescent reproductive health. 2020;16(3):39–46. (In Russ.) doi: 10.33029/1816-2134-2020-16-3-39-46
  21. Letifov GМ, Chebotareva YuYu, Kostoeva ZA. On the issue of vaginal dysbiosis in girls with urinary system infections. Nefrologiya. 2019;23(3):49–53. (In Russ.) doi: 10.24884/1561-6274-2019-23-3-49-53
  22. Chebotareva YuYu, Tangieva MYu, Kotieva IM, Petrov YuA, Gulyan MV. Method of modeling vaginitis. Patent RUS No. RU 2800715 C1. Byul. No. 21 from 26.07.2023. (In Russ.) EDN: GSSNPO
  23. Kuznetsova IV, Burchakova MN, Burchakov DI, Khadzhieva NH, Filippova GG. Psychogenic stress-dependent disorders of menstrual cycle: role of non-hormonal correction. Zdorove zhenshchiny. 2018;(10):68. (In Russ.) EDN: VAWZCQ
  24. Chebotareva YuYu, Letifov GM, Petrov YuA. The role of stress reactions in the genesis of menstrual cycle disorders in recurrent urinary tract infections in minors. Nephrology (Saint-Petersburg). 2023;27(2):85–90. (In Russ.) doi: 10.36485/1561-6274-2023-27-2-85-90
  25. Chebotareva YuYu, Petrov YuA. The role of stress factors in the genesis of oligomenorrhea in minors. Pediatric and adolescent reproductive health. 2021;17(4):89–98. (In Russ.) doi: 10.33029/1816-2134-2021-17-4-89-98

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. The frequency of microorganism colonies growth in the vaginal biotope of the examined patients (aerobic and anaerobic opportunistic microorganisms >104 GE/sample; fungi of the genus Candida spp. >103 GE/sample) (*р1–2=0.011, р1–3=0.003, р1–4=0.002; **р1–2=0.021, р1–3=0.011, р1–4=0.002)

Download (58KB)
Indexing metadata

© 2024 Eco-Vector