A systematic review of the safety and efficacy of platelet-rich plasma for the treatment of posttraumatic knee osteoarthritis
- Authors: Leonova E.I.1, Chirinskaite A.V.1, Sopova J.V.1
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Affiliations:
- Center for Transgenesis and Genome Editing, Institute of Translational Biomedicine, St. Petersburg State University
- Section: Reviews
- Submitted: 10.08.2023
- Accepted: 12.06.2024
- Published: 27.06.2024
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/568204
- DOI: https://doi.org/10.17816/KMJ568204
- ID: 568204
Cite item
Abstract
Injury of the knee joint can lead to a range of adverse outcomes and significantly contributes to the development of the knee osteoarthritis. Currently, autologous platelet-rich plasma is used as a promising and safe method of treating osteoarthritis. Such plasma contains various growth factors, some of which are secreted after platelet activation. These factors can trigger a regenerative response and improve the metabolic functions of damaged structures. However, there are different protocols for preparing platelet-rich plasma, which results in preparations with different amounts of bioactive substances. As a result, the data obtained on the effect of platelet-rich plasma on the restoration of hyaline cartilage of the knee joint are very contradictory. A search for publications on a given topic was performed in the eLIBRARY, PubMed (MEDLINE), Ovid, Science Direct, Google Scholar databases, and also a search was conducted for clinical trial data on the treatment of knee osteoarthritis with platelet-rich plasma over the past 20 years. Publications dealing with other aspects of the application of this technology were excluded from the search results. An analysis of published clinical trial results found that, in most cases, patients treated with platelet-rich plasma reported improved pain and joint function, with only three studies showing no difference between platelet-rich plasma and placebo. Thus, this technology is generally promising for use in the treatment of knee osteoarthritis, however, methods of obtaining and activating platelet-rich plasma, as well as the age and comorbidities of the patient, may affect the effectiveness of therapy.
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About the authors
Elena I. Leonova
Center for Transgenesis and Genome Editing, Institute of Translational Biomedicine, St. Petersburg State University
Email: e.leonova@spbu.ru
ORCID iD: 0000-0002-0236-3302
SPIN-code: 2573-1759
Cand. Sci. (Biol.), Director, Center of Transgenesis and Genome Editing, Institute of Translational Biomedicine
Russian Federation, St. PetersburgAngelina V. Chirinskaite
Center for Transgenesis and Genome Editing, Institute of Translational Biomedicine, St. Petersburg State University
Email: ChirinskaiteA@yandex.ru
ORCID iD: 0000-0002-7466-0680
SPIN-code: 3689-0110
Junior Researcher, Center of Transgenesis and Genome Editing, Institute of Translational Biomedicine
Russian Federation, St. PetersburgJulia V. Sopova
Center for Transgenesis and Genome Editing, Institute of Translational Biomedicine, St. Petersburg State University
Author for correspondence.
Email: y.sopova@spbu.ru
ORCID iD: 0000-0002-7825-273X
SPIN-code: 6019-1547
Cand. Sci. (Biol.), Leading Researcher, Center of Transgenesis and Genome Editing, Institute of Translational Biomedicine
Russian Federation, St. PetersburgReferences
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