Study of indicators of the immune status in HIV-infected patients with concurrent allergic pathology

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Aim. To study the indicators of the immune status and manifestations of allergic diseases in HIV-infected patients in the Novgorod region.

Methods. We studied the data of HIV-infected patients living in the Novgorod region for the years 2000–2021. A total of 1020 cases of HIV infection were studied, in which 121 (12%) patients were diagnosed with allergic reactions. In patients with allergic manifestations, the human immunodeficiency virus type 1 ribonucleic acid content was measured by the polymerase chain reaction method, and the indicators of the immune status (the content of lymphocytes, eosinophils, basophils, the levels of CD3+, CD3+CD4+, CD3+CD8+ cells, immunoregulatory index) were assessed. For statistical analysis, the Student's test (t) was used to assess the statistical significance of diffe¬rences in immune status indicators, and the Pearson χ2 test to assess the statistical significance of differences in allergic manifestations in patients with HIV.

Results. The subjects of the study were divided into 2 groups based on the levels of HIV viral load. Analysis of these groups using the Pearson χ2 test showed a statistically significant (p <0.012) correlation between high viral load and the development of drug hypersensitivity reaction in HIV-infected patients. The following etiology of allergic reactions was determined among the subjects: drug (59%), food (19%), pollen (5.7%), household (5.7%), che¬mical (1.9%), unspecified (6.7%). The study of the immune status in two groups did not reveal statistically significant differences (p >0.05). The study of the immune status indicators in HIV-infected patients with drug hypersensitivity reactions and different levels of viral load revealed a significantly higher level of CD3+ cells (p <0.003) in patients with drug hypersensitivity reactions and detectable viral load.

Conclusion. The study revealed statistically significant differences in the immune status of HIV-infected patients with drug hypersensitivity reactions living in the Novgorod region compared with HIV-infected patients without drug allergies.

Full Text

Restricted Access

About the authors

S A Nora

Yaroslav-the-Wise Novgorod State University

Author for correspondence.
Email: sergey.nora@novsu.ru
Russian Federation, Veliky Novgorod, Russia

G S Arkhipova

Yaroslav-the-Wise Novgorod State University

Email: sergey.nora@novsu.ru
Russian Federation, Veliky Novgorod, Russia

E I Arkhipova

Yaroslav-the-Wise Novgorod State University

Email: sergey.nora@novsu.ru
Russian Federation, Veliky Novgorod, Russia

N E Nikitina

Yaroslav-the-Wise Novgorod State University

Email: sergey.nora@novsu.ru
Russian Federation, Veliky Novgorod, Russia

S V Buikin

Yaroslav-the-Wise Novgorod State University

Email: sergey.nora@novsu.ru
Russian Federation, Veliky Novgorod, Russia

References

  1. Linnemann de Martínez D.L., López Pérez G., Xochihua Díaz L. Allergic diseases and infection with human immunodeficiency virus (HIV)-AIDS in pediatric patients. Rev. Alerg. Mex. 1997; 44 (2): 55–59. (In Spanish.) PMID: 9296827.
  2. Sousa M.J., Cadinha S., Mota M., Teixeira T., Malheiro D., Moreira da Silva J.P. Hypersensitivity to antiretroviral drugs. Eur. Ann. Allergy Clin. Immunol. 2018; 50 (6): 277–280. doi: 10.23822/EurAnnACI.1764-1489.42.
  3. Minhajat R., Djaharuddin I., Halim R., Benya¬min A.F., Bakri S. Drugs hypersensitivity reaction in patient with human immunodeficiency virus (HIV) infection. J. Allergy Ther. 2017; 8: 252. doi: 10.4172/2155–6121.1000252.
  4. German Advisory Committee Blood (Arbeitskreis Blut), Subgroup “Assessment of Pathogens Transmissible by Blood”. Human Immunodeficiency Virus (HIV). Transfus. Med. Hemother. 2016; 43 (3): 203–222. doi: 10.1159/000445852.
  5. Global HIV & AIDS statistics. Fact sheet, 2021. HIV ESTIMATES. ¬UNAIDS, 2021. https://www.unaids.org/ru/resources/fact-sheet (access date: 04.08.2021). (In Russ.)
  6. Acar M., Sutcu M., Umur O., Akturk H., Torun S.H., Tamay Z., Salman N., Somer A. Acquired immune deficiency syndrome in differential diagnosis of hyper-IgE-immunoglobulinemia: Pediatric case report. J. Trop. Pediatr. 2017; 63 (1): 82–84. doi: 10.1093/tropej/fmw053.
  7. Shor-Posner G., Miguez-Burbano M.J., Lu Y., Feaster D., Fletcher M., Sauberlich H., Baum M.K. Elevated IgE level in relationship to nutritional status and immune ¬parameters in early human immunodeficiency virus-1 disease. J. Allergy Clin. Immunol. 1995; 95 (4): 886–892. doi: 10.1016/s0091-6749(95)70133-8.
  8. Linhar L.S., Traebert J., Galato D., da Silva M.R., Schuelter-Trevisol F., Rovaris S.N., da Silva J. Allergic diseases in subjects under 18 years living with HIV. All. Asth. Clin. Immun. 2014; 10: 35. doi: 10.1186/1710-1492-10-35.
  9. Mokronosova M.A., Mats A.N. Infection and allergies: two sides of the same coin. Astma i allergiya. 2015; (4): 9–12. (In Russ.)
  10. Freidin M.V., Puzyrev V.P. Genomic bases of susceptibility to atopic diseases. Molekulyarnaya meditsina. 2007; (3): 26–35. (In Russ.)
  11. Hershey G.K.K., Friedrich M.F., Esswein L.A., Thomas M.L., Chatila T.A. The association of atopy with a gain of function mutation in the α-subunit of the interleukin 4 receptor. New Engl. J. Med. 1997; 337: 1720–1725. doi: 10.1056/NEJM199712113372403.
  12. Mitsuyasu H., Yanagihara Y., Mao X.Q., Gao P.S., Arinobu Y., Ihara K., Takabayashi A., Hara T., Enomoto T., Sasaki S., Kawai M., Hamasaki N., Shirakawa T., Hopkin J.M., Iauhara K. Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis. J. Immunol. 1999; 162: 1227–1231. PMID: 9973373.
  13. Simo¬nov R.O., Valishin D.A., Yapparov R.G. Acute allergies in HIV-infected patients with helminthic invasion, in Abstract book of “Diagnostika i lechenie glaznykh proyavleniy infektsionnykh i sistemnykh zabolevaniy”. (Abstract book of “Diagnostics and treatment of ocular manifestations of infectious and systemic diseases” conference.) 2018; 98–105. (In Russ.)
  14. Nora S.A., Arkhipov G.S., Kropachev I.G., Arkhipova E.I. Role of allergies in diagnostics and treatment of HIV-infection. Vestnik Novgorodskogo gosudarstvennogo universiteta. 2021; (1): 67–70. (In Russ.) doi: 10.34680/2076-8052.2021.1(122).67-70.
  15. Rhode D., Vanker A. Human immunodeficiency virus and allergic disease. Current Allergy Clin. Immunol. 2009; 22 (4): 168–172.

© 2021 Eco-Vector





This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies