B2-microglobulin as an indicator of proteinuria in chronic kidney diseases

Currently, the issues of studying the physiological role of B2-microglobulin attract the attention of many researchers, since it is a physiological component of all body fluids In recent years there have been reports about the leading role of the kidneys and, above all, the tubular nephron in the metabolism of B2-microglobulin. This circumstance served as the basis for the parallel determination of the content of β2-microglobulin in blood and urine to study a number of renal functions. The small molecular weight (11,800 daltons) and the small size of β2-microglobulin allow it to pass through an intact glomerular membrane. However, normally almost all (99.5%) of the filtered β2-microglobulin is absorbed and metabolized in cells