Efficacy of Sodium deoxyribonucleate in community-acquired pneumonia in children of school age
- Authors: Pikuza OI1, Fayzullina RA1, Suleymanova ZY.1, Zakirova AM1, Serdinskaya IN1
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Affiliations:
- Kazan State Medical University
- Issue: Vol 98, No 5 (2017)
- Pages: 736-742
- Section: Theoretical and clinical medicine
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/7027
- DOI: https://doi.org/10.17750/KMJ2017-736
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Abstract
Aim. To study efficacy of sodium deoxyribonucleate use for the treatment of community-acquired pneumonia in children of school age.
Methods. 102 children aged 7 to 17 years were observed: 25 relatively healthy children (control group), 39 children with community-acquired pneumonia, who received only conventional treatment (comparison group) and 38 patients with community-acquired pneumonia receiving complex treatment with additional sodium deoxyribonucleate (study group). All patients underwent clinical and instrumental and laboratory examination. Cytomorphologic features of neutrophils and epithelial cells, cytokine concentration (interleukin-8, -10 and -17, tumor necrosis factor α) were examined in nasal secret of patients with community-acquired pneumonia dynamically on different therapy regimens. Evaluation of dynamics of clinical signs was performed in the studied groups.
Results. In the study clinical efficacy of the medication was discovered and caused decreased disease duration, acceleration of inflammatory changes reparation in the lungs in rhinocytogram, decreased level of neutrophils and their destructive forms, decreased levels of pro-inflammatory cytokines - interleukin-8 and tumor necrosis factor α.
Conclusion. Sodium deoxyribonucleate enhances adaptive resources of mucosal immunity, leads to restoration of epithelium lining the upper respiratory airways and therefore potentiates local immunity.
About the authors
O I Pikuza
Kazan State Medical University
Author for correspondence.
Email: suleimanova_zulfia@mail.ru
Kazan, Russia
R A Fayzullina
Kazan State Medical University
Email: suleimanova_zulfia@mail.ru
Kazan, Russia
Z Ya Suleymanova
Kazan State Medical University
Email: suleimanova_zulfia@mail.ru
Kazan, Russia
A M Zakirova
Kazan State Medical University
Email: suleimanova_zulfia@mail.ru
Kazan, Russia
I N Serdinskaya
Kazan State Medical University
Email: suleimanova_zulfia@mail.ru
Kazan, Russia
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