Clinical and pathogenetic value of nitric oxide measurement in the blood of patients with bronchial asthma and essential hypertensio

Cover Page

Abstract


Aim. To evaluate the clinical and pathogenetic value of nitric oxide metabolites measurement in the blood of patients with bronchial asthma and essential hypertension.

Methods. The study included 91 patients. Three groups were identified: patients with bronchial asthma (30 patients, group 1), patients with bronchial asthma in combination with essential hypertension (31 patients, group 2), and patients with essential hypertension (30 patients, group 3). Measurement of the level of total nitric oxide metabolites in patients’ blood was performed with the use of spectrophotometric method in light spectrum based on Griess reaction.

Results. The median level of nitric oxide metabolites had the highest value in the blood of patients with bronchial asthma and accounted for 75.6 [70.4; 80.8] umol/L. Level of nitric oxide metabolites in the blood of patients with bronchial asthma in combination with essential hypertension and patients with essential hypertension was lower, accounting for 72.4 [66.2; 81.2] and 60.0 [54.6; 62.7] umol/L respectively (p <0.001). The tendency to increasing level of nitric oxide metabolites in the blood of patients with bronchial asthma according to disease severity and disease-modifying treatment was revealed. The level of nitric oxide metabolites in the blood of patients with severe bronchial asthma was 77.4 [71.6; 82.4] μmol/L, and in patients with moderate asthma it was 72.4 [70.4; 73.9] μmol/L.

Conclusion. The level of nitric oxide metabolites in the blood of patients with combination of bronchial asthma and essential hypertension had intermediate values compared with patients with bronchial asthma alone, who had the highest level, and with patients with essential hypertension alone, who had the lowest values.


About the authors

A V Shakhanov

Ryazan State Medical University named after Academician I.P. Pavlov

Author for correspondence.
Email: shakhanovav@gmail.com
Ryazan, Russia

E S Bel’skikh

Ryazan State Medical University named after Academician I.P. Pavlov

Email: shakhanovav@gmail.com
Ryazan, Russia

V A Lunyakov

Ryazan State Medical University named after Academician I.P. Pavlov

Email: shakhanovav@gmail.com
Ryazan, Russia

O M Uryas’ev

Ryazan State Medical University named after Academician I.P. Pavlov

Email: shakhanovav@gmail.com
Ryazan, Russia

References

  1. Верткин А.Л., Скотников А.С. Коморбидность. Леч. врач. 2013; (8): 78.
  2. Chen W., Lynd L.D., FitzGerald J.M. et al. Excess medical costs in patients with asthma and the role of comorbidity. Eur. Respir. J. 2016; 48 (6): 1584-1592. doi: 10.1183/13993003.01141-2016.
  3. Ghosh S., Erzurum S. Modulation of asthma pathogenesis by nitric oxide pathways and therapeutic opportunities. Drug Discov. Today Dis. Mech. 2012; 9 (3-4): e89-94. doi: 10.1016/j.ddmec.2012.10.004.
  4. Prado C., Martins M., Tibério I. Nitric oxide in asthma physiopathology. ISRN Allergy. 2011; 2011: 832560. doi: 10.5402/2011/832560.
  5. Aytekin M., Aulak K., Haserodt S. et al. Abnormal platelet aggregation in idiopathic pulmonary arterial hypertension: role of nitric oxide. AJP Lung Cell Mol. Physiol. 2012; 302 (6): L512-520. doi: 10.1152/ajplung.00289.2011.
  6. Белозёров В.К., Рубанова М.П., Вебер В.Р. и др. Эндотелийзависимая вазодилатация и состояние стенки сонной артерии. Кардиоваск. терап. и профил. 2014; 13 (S2): 16.
  7. Kumar R., Kohli S., Mishra A. et al. Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension. Am. J. Hypertens. 2015; 28 (2): 239-247. doi: 10.1093/ajh/hpu130.
  8. Hernansanz-Agustín P., Izquierdo-Álvarez A., García-Ortiz A. et al. Nitrosothiols in the immune system: signaling and protection. Antioxid. Redox Signal. 2013; 18 (3): 288-308. doi: 10.1089/ars.2012.4765.
  9. Метельская В.А., Гуманова Н.Г. Скрининг-метод определения уровня метаболитов оксида азота в сыворотке крови. Клин. лаб. диагностика. 2005; (6): 15.
  10. Абатуров А.Е. Роль монооксида азота в системе неспецифической защиты респираторного тракта. Здоровье ребёнка. 2009; (1): 130-137.
  11. Козина О.В. Метаболизм нитрозотиолов при аллергическом воспалении. Бюлл. СО РАМН. 2010; 30 (1): 109-116.

Statistics

Views

Abstract - 743

PDF (Russian) - 217

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions


© 2017 Shakhanov A.V., Bel’skikh E.S., Lunyakov V.A., Uryas’ev O.M.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.





This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies