Hormonal and Immunological Changes Under Complex Stress in Patients with Different Predominant Temperamental Activity



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Abstract

BACKGROUND: To prevent various diseases and develop personalized treatment strategies, data are required on the immunological and hormonal changes under complex stress in respondents with different temperamental activity.

AIM: To study hormonal and immunological changes in respondents with different temperamental activity under complex stress.

METHODS: A total of 251 volunteers were examined (46% male, mean age 35.80 ± 9.48 years). Experimental groups were created by the ratio of different types of temperamental activity, i.e. psychomotor (n = 75), intellectual (n = 59), and communicative (n = 88). Venous blood samples were drawn before and after a complex stress, including psychomotor, intellectual, and communication tests. We assessed hormone levels (cortisol, epinephrine, norepinephrine, serotonin, and dopamine), genotypes (BDNF, COMT), and cytokines (IL-4, IL-6, IL-10, TNF-α). Statistical tests included Pearson chi-square test, Wilcoxon signed-rank test (W test), Mann–Whitney test (U test), Kruskal–Wallis test (H test), and Spearman’s rank correlation coefficient.

RESULTS: Complex stress in respondents with a predominantly psychomotor temperamental activity is associated with a decrease in serum cortisol (W = 6.187, p < 0.001) and an increase in epinephrine (W = 4.349, p < 0.002) and IL-4 (W = 3.601, p < 0.01). Changes in cortisol correlate with changes in norepinephrine (rs = 0.318, p = 0.006). Changes in serotonin negatively correlate with changes in IL-6 (rs = −0.324, p = 0.005). Changes in IL-6 correlate with changes in TNFα (rs = 0.424, p < 0.001). IL-6 decreases from 21.6 to 2.8 pg/ml (W = 2.525, p = 0.012). Complex stress in respondents with a predominantly intellectual temperamental activity is associated with a decrease in serum cortisol (W = 5.174, p < 0.001) and an increase in norepinephrine (W = 3.049, p < 0.002) and IL-4 (W = 2.582, p < 0.01). Changes in epinephrine correlate with changes in norepinephrine (rs = 0.382, p = 0.003) and dopamine (rs = 0.325, p = 0.012). Changes in serotonin negatively correlate with changes in IL-6 (rs = 0.264, p = 0.044). IL-10 decreases from 6.4 to 5.9 pg/ml (W = 3.313, p < 0.001). Complex stress in respondents with a predominantly communicative temperamental activity is associated with a decrease in cortisol (W = 7.914, p < 0.001) and an increase in norepinephrine (W = 3.318, p < 0.002) and IL-4 (W = 4.238, p < 0.01). Changes in epinephrine is associated with changes in norepinephrine (rs = 0.215, p = 0.045) and cortisol (rs = 0.239, p = 0.026). IL-10 decreases from 7.1 to 6.2 pg/ml (W = 5.449, p < 0.001).

CONCLUSION: We identified special hormonal and immunological changes in the blood serum under complex stress in respondents with different predominant temperamental activity.

About the authors

Elena V. Volkova

Institute of Psychology of the Russian Academy of Sciences

Email: volkovaev@ipran.ru
ORCID iD: 0000-0003-3809-3639
SPIN-code: 8375-5018

Dr. Sci. (Psychology), Chief Research Associate, Head, V.N. Druzhinin Laboratory of Psychology of Abilities and Mental Resources

Russian Federation, Moscow

Irina O. Kuvaeva

Institute of Psychology of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin

Author for correspondence.
Email: irina.kuvaeva@urfu.ru
ORCID iD: 0000-0001-5451-0725
SPIN-code: 7244-9678

Cand. Sci. (Psychology), Research Associate, V.N. Druzhinin Laboratory of Psychology of Abilities and Mental Resources, Assistant Professor, Depart. of Developmental and Educational Psychology of the Department of Psychology

Russian Federation, Moscow; Ekaterinburg

Andrey V. Varlamov

Institute of Psychology of the Russian Academy of Sciences; Ryazan State Medical University

Email: andrey.varlamov.62@gmail.com
ORCID iD: 0000-0002-6144-6036
SPIN-code: 1397-5213

Specialist, Centre of Practical Psychology, Junior Research Associate, Druzhinin Laboratory of Psychology of Abilities and Mental Resources

Russian Federation, Moscow; Ryazan

Natalia E. Volkova

Institute of Psychology of the Russian Academy of Sciences

Email: volkovane@ipran.ru
ORCID iD: 0000-0001-6225-6288
SPIN-code: 5318-5587

Junior Research Associate, Druzhinin Laboratory of Psychology of Abilities and Mental Resources

Russian Federation, Moscow

Denis A. Dokuchaev

Institute of Psychology of the Russian Academy of Sciences

Email: dokuchaevda@ipran.ru
ORCID iD: 0000-0003-3432-0056
SPIN-code: 1257-9376

Junior Research Associate, Druzhinin Laboratory of Psychology of Abilities and Mental Resources

Russian Federation, Moscow

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