A rare form of metabolic myopathy in a neurologist’s practice

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Secondary metabolic myopathies develop in endocrine pathologies, different somatic diseases, electrolyte disorders and in some vitamin deficiency. Myopathic syndrome caused by vitamin D deficit is a rear pathologic condition, for this reason it is difficult to diagnose it. Proper diagnosis has a vital importance for proper treatment choice. The article describes a rear form of the metabolic myopathy in a young female admitted to the neurology department because of significant leg weakness. A thorough examination revealed no pathology of internal organs. On physical examination moderate lower flaccid paresis with reduced tendon reflexes was revealed. Muscle tone was normal. The absence of systemic inflammatory changes in blood tests as well as normal biopsy results ruled out dermatomyositis and polymyositis. Blood tests revealed deficiency of 25-OH-vitamin D. On vitamin D monotherapy leg weakness completely resolved. In case of myopathic syndrome it is necessary to have in mind such rear causes for its development as vitamin D deficiency.

About the authors

K L Zagidullina

City clinical hospital №7

Author for correspondence.
Email: polikarpova_90@mail.ru

N A Popova

City clinical hospital №7; Kazan state medical university

Email: polikarpova_90@mail.ru

Yu V Filippova

Polyclinic «Salvage»

Email: polikarpova_90@mail.ru


  1. Калинченко С.Ю., Пигарова Е.А., Гусакова Д.А. и др. Витамин D и мочекаменная болезнь. Consil. Med. 2012; 14 (12): 97-102.
  2. Каронова Т.Л., Гринёва Е.Н., Никитина И.Л. и др. Распространённость дефицита витамина D в Северо-Западном регионе РФ среди жителей г. Санкт- Петербурга и г. Петрозаводска. Остеопороз и остеопатии. 2013; (3): 3-7.
  3. Пигарова Е.А., Плещева А.В., Дзеранова Л.К. Влияние витамина D на иммунную систему. Иммунология. 2015; 36 (1): 62-66.
  4. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е. и др. Дефицит витамина D у взрослых: диагностика, лечение и профилактика. Клинические рекомендации. Российская ассоциация эндокринологов. М. 2015; 75 с.
  5. Спиричев В.Б. О биологических эффектах витамина D. Педиатрия. 2011; 90 (6): 113-119.
  6. Вест. Дж.С. Секреты ревматологии. СПб.: Невский диалект. 2001; 768 с.
  7. Bischoff-Ferrari H.A., Burckhardt P., Quack-Loetscher K. et al. Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss population. Report written by a group of experts on behalf of the Federal Commission for Nutrition (FCN). 2012. http://www.iccidd.org/p142000804.html (access date: 23.09.2016).
  8. Chen T.C., Chimeh F., Lu Z. et al. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch. Biochem. Biophys. 2007; 460: 213-217. http://dx.doi.org/10.1016/j.abb.2006.12.017
  9. Chen T.C., Holick M.F. Photobiology of vitamin D. Vitamin D physiology, molecular biology, and clinical applications. Humana Press. 1998; 17-37.
  10. Heaney R.P., Davies K.M., Chen T.C. et al. Human serum 25-hydroxychole-calciferol response to extended oral dosing with cholecalciferol. Am. J. Clin. Nutr. 2003; 77 (1): 204.
  11. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A. et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011; 96 (7): 30. http://dx.doi.org/10.1210/jc.2011-0385
  12. Mithal A. Treatment of vitamin D deficiency. Endocrine case management ICE/ENDO 2014; 37-39.
  13. Mithal A., Wahl D.A., Bonjour J.P. et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos. Int. 2009; 20: 182. http://dx.doi.org/10.1007/s00198-009-1030-y
  14. Pludowski P., Holick M.F., Pilz S. et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality - a review of recent evidence. Autoimmun. Rev. 2013; 12: 89. http://dx.doi.org/10.1016/j.autrev.2013.02.004
  15. Suresh E.I., Wimalaratna S. Proximal myopathy: diagnostic approach and initial management. Postgrad Med. J. 2013; 89: 70. http://dx.doi.org/10.1136/postgradmedj-2013-131752

© 2016 Zagidullina K.L., Popova N.A., Filippova Y.V.

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