Hemostatic system state and cytokine profile in patients with metabolic syndrome

Aim. Examine the hemostasis state and cytokine profile in patients with metabolic syndrome.

Methods. The study included 71 patients aged 20 to 44 years. Patients were allocated to four groups matched on age: the first group - females with the metabolic syndrome (n=15), the second - healthy females (control group, n=20), the third - males with the metabolic syndrome (n=19), the fourth group - healthy males (control group, n=17). Laboratory parameters of lipid, carbohydrate metabolism, hemostatic parameters, the levels of cytokines were measured in peripheral blood.

Results. Changes in plasma, fibrinolytic and anticoagulant links were revealed in metabolic syndrome (increased concentration of fibrinogen, soluble fibrin monomer complex, D-dimer - in patients of both gender, increased level of tissue factor pathway inhibitor and plasminogen activator inhibitor type 1 - in females). Metabolic syndrome was associated with an increased concentration of interleukin-6 (males and females), interleukin-10 (females) and decreased level of interleukin-8 (males) in peripheral blood. In females, the interrelation between fibrinolytic system activity and pro-inflammatory cytokines serum levels was revealed. In males with metabolic syndrome, a correlation of interleukin-6 pro-inflammatory cytokine level and D-dimer, interferon γ, insulin and insulin resistance index (HOMA) levels was discovered. The level of anti-inflammatory cytokine interleukin-10 correlated with serum triglycerides level.

Conclusion. Metabolic syndrome in patients of younger age is accompanied by changes in plasma fibrinolytic links of hemostasis, regardless of gender. In patients with metabolic syndrome, there are no gender differences in levels of peripheral blood cytokines inherent in healthy people.