Vascular endothelial growth factor role in predicting vascular disorders in pregnant with fetal growth restriction syndrome

Cover Page


Cite item

Full Text

Abstract

The review covers the up-to-date data of vascular endothelial growth factor role in forming of placental blood circulation in non-complicated pregnancy and in fetal growth retardation syndrome. It is shown that the normal trophoblast invasion to the spiral arteries wall in the myometrium and adequate remodeling of spiral arteries are essential for the normal fetal growth and development. The processes of blood vessels formation - vasculogenesis and angiogenesis - are described in detail. The process of angiogenesis regulation by growth factors and their receptors is reviewed. The importance of angiogenic and antiangiogenic factors coordinated action for the adequate placental microvasculature formation and normal fetal development is described. The growth factor complexes and their receptors formation processes and competition for receptor binding, as well as the role of placental growth factor in uteroplacental complex angiogenesis are analyzed. It is shown that the serum growth factors represent the mechanisms of pathologic reactions in placental insufficiency and fetal growth restriction syndrome. Special attention is given to the family of vascular endothelial growth factor as for the most important angiogenesis regulator. To determine the physiological role of vascular endothelial growth factor and to assess the its influence on angiogenesis and adequate uteroplacental and fetoplacental blood circulation formation, the features of vascular endothelial growth factor chemical structure are described. Determining the vascular endothelial growth factor in blood may be used to assess the mother-placenta-fetus system formation. The need for developing the criteria for choosing the optimal delivery term in pregnant with fetal growth restriction syndrome is discussed.

About the authors

E V Ul’yanina

Kazan State Medical University, Kazan, Russia

Author for correspondence.
Email: ualena87@yandex.ru

I F Fatkullin

Kazan State Medical University, Kazan, Russia

Email: ualena87@yandex.ru

References

  1. Бурлев В.А., Зайдиева З.С., Тютюнник В.Л. и др. Роль факторов роста в развитии плацентарной недостаточности // Пробл. репрод. - 1999. - №6. - С. 7-12.
  2. Бурлев В.А., Павлович С.В. Ангиогенез и ангиогенные факторы роста в регуляции репродуктивной системы у женщин // Пробл. репрод. - 1999. - №5. - С. 6-13.
  3. Гугушвили Н.А., Сичинава Л.Г., Ганковская Л.В. Клинико-патогенетическое обоснование досрочного родоразрешения при задержке роста плода // Вопр. гин., акуш. и перин. - 2013. - Т. 12, №2. - С. 22-28.
  4. Зиганшина М.М., Кречетова Л.В., Ванько Л.В. и др. Про- и антиангиогенные факторы в патогенезе ранних потерь беременности. Часть 1. Особенности содержания про- и антиангиогенных сывороточных факторов в ранние сроки беременности // Акуш. и гин. - 2012. - №3. - С. 14-19.
  5. Савельева Г.М., Фёдорова М.В., Клименко П.А. и др. Плацентарная недостаточность. - М.: Медицина, 1991. - 276 с.
  6. Стрижаков А.Н., Кушлинский Н.Е., Тимохина Е.В., Тарабрина Т.В. Роль ангиогенных факторов роста в прогнозировании плацентарной недостаточности // Вопр. гин., акуш. и перин. - 2009. - Т. 8, №4. - С. 5-11.
  7. Стрижаков А.Н., Игнатко И.В., Тимохина Е.В., Белоцерковцева Л.Д. Синдром задержки роста плода. Патогенез. Диагностика. Лечение. Акушерская тактика: монография. - М.: ГЭОТАР-Медиа, 2013. - 120 с.
  8. Autiero M., Luttun A., Tjwa M. et al. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders // J. Thromb Haemost. - 2003. - Vol. 1. - P. 1356-1370. http://dx.doi.org/10.1046/j.1538-7836.2003.00263.x
  9. Brosens I.A., Robertson W.B., Dixon H.G. The role of the spiral arteries in the pathogenesis of preeclampsia // Obstet. Gynecol. Annu. - 1972. - Vol. 1. - P. 177-191.
  10. Brosens I.A., Dixon H.G., Robertson W.B. Fetal growth retardation and the arteries of the placental bed // Br. J. Obstet. Gynaecol. - 1977. - Vol. 84. - P. 656-663. http://dx.doi.org/10.1111/j.1471-0528.1977.tb12676.x
  11. Carmeliet P., Moons L., Luttun A. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions // Nat. Med. - 2001. - Vol. 7. - P. 575-583. http://dx.doi.org/10.1038/87904
  12. Charnock-Jones D.S., Kaufmann P., Mayhew T.M. Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation // Placenta. - 2004. - Vol. 25. - P. 103-113. http://dx.doi.org/10.1016/j.placenta.2003.10.004
  13. Eliceiri B.P., Paul R., Schwartzberg P.L. et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability // Mol. Cell. - 1999. - Vol. 4. - P. 915-924. http://dx.doi.org/10.1016/S1097-2765(00)80221-X
  14. Ferrara N., Carver-Moore K., Chen H. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene // Nature. - 1996. - Vol. 380. - P. 439-442. http://dx.doi.org/10.1038/380439a0
  15. Ferrara N., Carver-Moore K., Chen H. et al. Role of vascular endothelial growth factor in regulation of physiological angiogenesis // Am. J. Physiol. Cell. Physiol. - 2001. - Vol. 280. - P. 1358-1366.
  16. Ferrara N., Gerber H.P., Le Couter J. The biology of VEGF and its receptors // Nat. Med. - 2003. - Vol. 9. - P. 669-676. http://dx.doi.org/10.1038/nm0603-669
  17. Kaufmann P., Black S., Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia // Biol. Reprod. - 2003. - Vol. 69. - P. 1-7. http://dx.doi.org/10.1095/biolreprod.102.014977
  18. Kaufmann P., Mayhew T.M., Charnock-Jones D.S. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy // Placenta. - 2004. - Vol. 25. - P. 114-126. http://dx.doi.org/10.1016/j.placenta.2003.10.009
  19. Kerbel R., Folkman J. Clinical translation of angiogenesis inhibitors // Nat. Rev. Cancer. - 2002. - Vol. 2. - P. 727-730. http://dx.doi.org/10.1038/nrc905
  20. Krauss T., Pauer H.U., Augustin H.G. Prospective analysis of placental growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia // Hypertens. Pregnancy. - 2004. - Vol. 23. - P. 101-111. http://dx.doi.org/10.1081/PRG-120028286
  21. Mari G., Hanif F. Intrauterine growth retriction: how to manage and when to deliver // Clin. Obstet. Gynecol. - 2007. - Vol. 50, N 2. - P. 497-509. http://dx.doi.org/10.1097/GRF.0b013e31804c96a9
  22. Maulik D. Management of fetal growth restriction: an evidence-based approach // Clin. Obstet. Gynecol. - 2006. - Vol. 49, N 2. - P. 320-334. http://dx.doi.org/10.1097/00003081-200606000-00013
  23. McMahon G. VEGF receptor signaling in tumor angiogenesis // The Oncologist. - 2000. - Vol. 5, N 11. - P. 3-10. http://dx.doi.org/10.1634/theoncologist.5-suppl_1-3
  24. Otrock Z.K., Makarem J.A., Shamseddine A.I. Vascular endothelial growth factor family of ligands and receptors: review // Blood Cells Mol. Dis. - 2007. - Vol. 38. - P. 258-268.
  25. Romero R., Nien J.K., Espinoza J. et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate // J. Matern Fetal Neon. Med. - 2008. - Vol. 21, N 1. - P. 9-23.
  26. Shore V.H., Wang T.H., Wang C.L. et al. Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast // Placenta. - 1997. - Vol. 18. - P. 657-665. http://dx.doi.org/10.1016/S0143-4004(97)90007-2
  27. Sinclair J.C. Meta analysis of randomized controlled trials of antenatal corticosteroid for the prevention of respiratory distress syndrome: discussion // A. J. Obstet. Gynecol. - 1995. - Vol. 173, N 1. - P. 335-344. http://dx.doi.org/10.1016/0002-9378(95)90223-6
  28. Sugimoto H., Hamano Y., Charytan D. et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induced proteinuria // J. Biol. Chem. - 2003. - Vol. 278. - P. 12 605-12 608. http://dx.doi.org/10.1016/j.bcmd.2006.12.003

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

© 2015 Ul’yanina E.V., Fatkullin I.F.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.




This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies