Determination of differentiated hemodynamics types based on assessment of integral circulation indicators in healthy people and patients with hypertension

Aim. To develop a method for determination of the differentiated types of hemodynamics based on the data analysis of integral circulation indicators.

Methods. The method for determination of the differentiated hemodynamics types was developed based on the data analysis of integral circulation indicators - cardiac output, heart rate, total peripheral vascular resistance and modulus of volume elasticity. The types of hemodynamics - hyperkinetic, eukinetic, hypokinetic - were determined by cardiac output. Tachy-, normo- and bradisistolic subtypes were determined by the heart rate, subtypes with a predominance of vascular resistance and arterial stiffness were determined by the modulus of volume elasticity and total peripheral vascular resistance ratio. Four groups of patients were examined. The first group included 63 patients with I-III degree of arterial hypertension aged 18 to 77 years, mean age 48.9±12.38 (M±σ). The second group - 82 patients with primary hypothyroidism and I-III degree of arterial hypertension aged of 41 to 75 years, 59.8±7.9 years (M±σ). The third group - 33 patients with rheumatoid arthritis and I-III degree of arterial hypertension aged 17 to 67 years, 47.2±8.12 years (M±σ). The control group included 32 healthy volunteers aged 21 to 37 years, 24.7±5.34 years (M±σ).

Results. Eukinetic and hyperkinetic circulation types with predominance of peripheral vascular resistance were mostly identified in healthy volunteers. Eukinetic type of hemodynamic with predominance of peripheral vascular resistance is typical for patients with hypothyroidism and arterial hypertension, and for patients with rheumatoid arthritis and arterial hypertension hyperkinetic and eukinetic types with predominance of the arterial system rigidity are characteristic. Eukinetic and hypokinetic circulation types with predominance of both peripheral resistance and arterial stiffness are mostly present in essential hypertension.

Conclusion. Developed method of distinguishing the differentiated types of hemodynamics allows determining the hemodynamic heterogeneity in both healthy people and patients with hypertension.