Correction of atrophic post-acne scars with ablative erbium laser, taking into account the predominant type of scar

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Abstract

Background. The choice of an effective method of laser correction of atrophic post-acne scars, suitable for a particular type of scar, remains a difficult task, despite the variety of interventions.

Aim. To study the effectiveness of a combination of planar and fractional laser ablation in patients with atrophic post-acne scars, taking into account the predominant type of scar.

Material and methods. An open clinical intervention study included 60 patients with II–IV scar severity grade, 36 females and 24 males, with a mean age of 28.87±4.81 years. The predominance of V-shaped scars was observed in 11 (18.3%) patients, U-shaped — in 29 (48.3%), M-shaped — in 12 (20.0%), macular — in 8 (13.3%) patients. An erbium laser with a wavelength of 2940 nm was used to resurface the edge of the scars, followed by fractional ablation of the affected area. The change in the severity and quantitative index of the severity of post-acne scars after treatment, as well as the results on the international scale of aesthetic improvement, were evaluated. The safety of the method was assessed during a clinical examination on the 7th day after each procedure and 3 months after the last one, any adverse events and complications were recorded. The significance of differences was calculated using the Wilcoxon, Mann–Whitney, Kruskal–Wallis and the χ2 tests. Differences were considered statistically significant at p <0.05.

Results. Reduction of scar severity was registered, the quantitative index after treatment decreased from 11.4±3.25 to 6.2±3.1 points (p=0.000, Wilcoxon criterion). Regression of quantitative indices was established in patients with U-shaped and macular scars compared with patients with a predominance of M- and V-shaped scars (p ≤0.05, Mann–Whitney test). The average effectiveness of treatment on a scale of aesthetic improvement was 2.42±0.72 points, in 33 (55.0%) people the result corresponded to a significant improvement, in 19 (31.7%) — moderately pronounced improvement, a noticeable improvement in appearance compared to baseline was noted in 8 (13.3%) patients (χ2=23.55, p <0.000). Complications of procedures were not registered.

Conclusion. Correction of atrophic scars with an erbium laser, which combines planar and fractional ablation, is effective and safe for various types of atrophic scars; the optimal result is achieved in patients with U-shaped and macular scars.

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About the authors

Marina A. Ufimtseva

Ural State Medical University

Email: mail-m@mail.ru
ORCID iD: 0000-0002-4335-9334
SPIN-code: 4753-7210

M.D., D. Sci. (Med.), Prof., Head of Depart., Depart. of Dermatovenereology

Russian Federation, Yekaterinburg, Russia

Natalya V. Simonova

Ural State Medical University

Author for correspondence.
Email: nsimonova1@icloud.com
ORCID iD: 0000-0002-3330-2609
SPIN-code: 8323-6563

M.D., Assist., Depart. of Dermatovenereology

Russian Federation, Yekaterinburg, Russia

Kseniya N. Sorokina

Ural State Medical University

Email: ksenia.n.sorokina@mail.ru
ORCID iD: 0000-0003-3513-516X
SPIN-code: 1912-2319

M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Dermatovenereology

Russian Federation, Yekaterinburg, Russia

References

  1. Ufimtseva MA, Simonova NV, Bochkarev JuM, Zhunisova DS, Mylnikova ES. On the issue of assessing the quality of life of patients with acne scars. Farmateka. 2020;(8):24–27. (In Russ.) doi: 10.18565/pharmateca.2020.8.24-27.
  2. Ufimtseva MA, Simonova NV, Bochkarev YuM. Study of quality of life indicators in patients with atrophic postacne scars after laser ablation techniques. Uralskiy meditsinskiy zhurnal. 2021;20(3):67–72. (In Russ.) doi: 10.52420/2071-5943-2021-20-3-67-72.
  3. Chuah SY, Goh CL. The impact of post-acne scars on the quality of life among young adults in Singapore. J Cutan Aesthet Surg. 2015;8(3):153–158. doi: 10.4103/0974-2077.167272.
  4. Tan J, Kang S, Leyden J. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the USA. J Drugs Dermatol. 2017;16(2):97–102. PMID: 28300850.
  5. Dréno B, Tan J, Kang S, Rueda MJ, Torres Lozada V, Bettoli V, Layton AM. How people with facial acne scars are perceived in society: An online survey. Dermatol Ther (Heidelb). 2016;6: 07–218. doi: 10.1007/s13555-016-0113-x.
  6. Tan J, Beissert S, Cook-Bolden F, Chavda R, Harper J, Hebert A, Lain E, Layton A, Rocha M, Weiss J, Dréno B. Evaluation of psychological well-being and social impact of atrophic acne scarring: A multinational, mixed-methods study. JAAD Int. 2021;6:43–50. doi: 10.1016/j.jdin.2021.11.006.
  7. Tan J. Acne and scarring: Facing the issue to optimize outcomes. J Drugs Dermatol. 2018;17(12):s43. PMID: 30586480.
  8. Klinicheskie rekomendatsii Rossiyskogo obshhestva dermatovenerologov i kosmetologov. Akne. (Clinical recommendations of the Russian Society of Dermatovenerologists and Cosmetologists. Acne.) https://www.cnikvi.ru/docs/clinic_recs/klinicheskie-rekomendatsii-2017 (access date: 26.11.2021). (In Russ.)
  9. Dréno B, Bissonnette R, Gagné-Henley A, Barankin B, Lynde C, Chavda R, Kerrouche N, Tan J. Long-term effectiveness and safety of up to 48 weeks' treatment with topical adapalene 0.3%/Benzoyl Peroxide 2.5% gel in the prevention and reduction of atrophic acne scars in moderate and severe facial acne. Am J Clin Dermatol. 2019;20(5):725–732. doi: 10.1007/s40257-019-00454-6.
  10. Goodarzi A. Acne scar: A review of classification and treatment. Journal of Critical Reviews. 2020;7(7):1108–1114.
  11. Karabut MM, Gladkova ND, Feldshtein FI. Fractional Laser Photothermolysis in the Treatment of Skin Defects: Possibilities and Effectiveness (Review). Sovremennie tehnologii v medicine. 2016;8(2):98–108. (In Russ.) doi: 10.17691/stm2016.8.2.14.
  12. Sardana K, Manjhi M, Garg VK. Which type of atrophic acne scar (ice-pick, boxcar, or rolling) responds to nonablative fractional laser therapy? Dermatol Surg. 2014;40(3):288–300. doi: 10.1111/dsu.12428.
  13. Taub AM. The treatment of acne scars, a 30-year journey. Am J Clin Dermatol. 2019;20(5):683–690. doi: 10.1007/s40257-019-00451-9.
  14. Kruglova LS, Kolcheva PA, Korchazhkina NB. About modern methods of acne-scars correction. Journal of New Medical Technologies. 2018;25(4):155–163. (In Russ.) doi: 10.24411/1609-2163-2018-16316.
  15. Olisova OJu, Agavyan DV. Treatment of postoperative scars with combined use of CO2 laser ablation and autologous platelet enriched plasma. Rossiyskiy zhurnal kozhnykh i ve-nericheskikh bolezney. 2018;21(1):48–52. (In Russ.) doi: 10.18821/1560-9588-2018-21-1-48-52.
  16. Talybova AP. The combined laser technologies in correction of atrophic scars. Fizioterapevt. 2018;(5):57–64. (In Russ.)
  17. Majid I, Imran S. Fractional CO2 laser resurfacing as monotherapy in the treatment of atrophic facial acne scars. J Cutan Aesthet Surg. 2014;7(2):87–92. doi: 10.4103/0974-2077.138326.
  18. Kravvas G, Al-Niaimi F. A systematic review of treatments for acne scarring. Part 2: Energy-based techniques. Scars Burn Heal. 2018. doi: 10.1177/2059513118793420.
  19. Xiao A, Ettefagh L. Laser revision of scars. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. https://www.ncbi.nlm.nih.gov/books/NBK539686/ (access date: 27.12.2021).
  20. Sadick NS, Cardona A. Laser treatment for facial acne scars: A review. Journal of Cosmetic and Laser Therapy. 2018;20(7–8):424–435. doi: 10.1080/14764172.2018.1461230.
  21. Talybova AP, Kruglova LS, Stenko AG. Ultraphonophoresis of enzyme drugs in treatment of postacne scars. Russian Journal of the Physial Therapy, Balneotherapy and Rehabilitation. 2017;16(5):254–256. (In Russ.) doi: 10.18821/1681-3456-2017-16-5-254-256.
  22. You H-Y, Kim D-W, Yoon E-S, Park S-H. Comparison of four different lasers for acne scars: Resurfacing and fractional lasers. J Plast Reconstr Aesthet Surg. 2016;69(4):87–95. doi: 10.1016/j.bjps.2015.12.012.
  23. Gupta A, Kaur M, Patra S, Khunger N, Gupta S. Evidence-based surgical management of post-acne scarring in skin of color. J Cutan Aesthet Surg. 2020;13(2):124–141. doi: 10.4103/JCAS.JCAS_154_19.
  24. Kutlubay Z, Gokdemir G. Treatment of atrophic facial acne scars with the Er:YAG laser: A Turkish experience. J Cosmet Laser Ther. 2010;2:65–72. doi: 10.3109/14764171003706141.
  25. Min S, Park SY, Moon J, Kwon HH, Yoon JY, Suh DH. Comparison between Er:YAG laser and bipolar radiofrequency combined with infrared diode laser for the treatment of acne scars: Differential expression of fibrogenetic biomolecules may be associated with differences in efficacy between ablative and non-ablative laser treatment. Lasers Surg Med. 2017;49(4):341–347. doi: 10.1002/lsm.22607.
  26. Manturova NE, Talybova AM, Kruglova LS, Stenko AG. Prevention and treatment of atrophic post-acne scars. Klinicheskaya dermatologiya i venerologiya. 2018;17(5):91–100. (In Russ.)
  27. Salameh F, Shumaker PR, Goodman GJ. Energy-based devices for the treatment of acne scars: 2021 international consensus recommendations. Lasers Surg Med. 2022;54:10–26. doi: 10.1002/lsm.23484.
  28. Igoshina AV, Bondarenko NV, Gryazeva NV. Laser technologies for post-acne scar correction. Farmateka. 2019;(8):53–58. (In Russ). doi: 10.18565/pharmateca.2019.8.53-58.
  29. Potekaev NN, Kruglova LS. Lazer v dermatologii i kosmetologii. (Laser in dermatology and cosmetology.) Moscow: Aprel’; 2015. 289 р. (In Russ.)
  30. Riggs K, Keller M, Humphreys TR. Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet. Clin Dermatol. 2007;25(5):462–473. doi: 10.1016/j.clindermatol.2007.07.003.
  31. Holcomb JD. Versatility of erbium YAG laser: from fractional skin rejuvenation to full-field skin resurfacing. Facial Plast Surg Clin North Am. 2011;19(2):261–73. doi: 10.1016/j.fsc.2011.04.005.
  32. Kurganskaya IG, Klyuchareva SV, Cherkashina IV. A combined high-intensity laser therapy in the complex treatment of patients with post-acne atrophic scars. Kremlyevskaya meditsina. Klinicheskiy vestnik. 2021;(1):31–36. (In Russ.) doi: 10.26269/tecy-af23.
  33. Wat H, Wu DC, Chan HH. Fractional resurfacing in the Asian patient: Current state of the art. Lasers Surg Med. 2017;49(1):45–59. doi: 10.1002/lsm.22579.
  34. Abdel Hay R, Shalaby K, Zaher H, Hafez V, Chi CC, Dimitri S, Nabhan AF, Layton AM. Interventions for acne scars. Cochrane Database Syst Rev. 2016;4(4):CD011946. doi: 10.1002/14651858.CD011946.pub2.
  35. Goodman GJ, Baron JA. Postacne scarring: a qualitative global scarring grading system. Dermatol Surg. 2006;32(12):1458–1466. doi: 10.1111/j.1524-4725.2006.32354.x
  36. Goodman GJ, Baron JA. Postacne scarring — a quantitative global scarring grading system. J Cosmet Dermatol. 2006;5(1):48–52. doi: 10.1111/j.1473-2165.2006.00222.x.
  37. Fife D. Practical evaluation and management of atrophic acne scars: Tips for the general dermatologist. J Clin Aesthet Dermatol. 2011;4(8):50–57. PMID: 21909457.
  38. Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol. 2001;45(1):109–117. doi: 10.1067/mjd.2001.113451.
  39. Narins RS, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg. 2003;29(6):588–595. doi: 10.1046/j.1524-4725.2003.29150.x.
  40. Dréno B, Khammari A, Orain N. ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology. Dermatol. 2007;214(1):46–51. doi: 10.1159/000096912.
  41. Chathra N, Mysore M. Resurfacing of facial acne scars with a new variable-pulsed Er:YAG laser in Fitzpatrick skin types IV–V. J Cutan Aesthet Surg. 2018;11:20–25. doi: 10.4103/JCAS.JCAS_4_18.

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