Antidotes of cholinesterase inhibitors of the section of low-toxic phosphoroorganic сompounds

The toxicity, anticholinesterase activity and antagonism with anticholinesterase substances of different phosphoroorganic compounds are studied. The antagonism of these drugs with anticholinesterase substances is connected with their capacity to interact reversibly with active surface of cholinesterase and to protect thic enzyme against inhibition, to show anticonvulsive activity, to -suppress liver monooxygenase system function. One of the representatives of the series — dimephosphone — has potentiated the antidote effects on atropine M-cholinoblockator and diperoxime cholinesterase reactivator and has normalized some disturbed functions of animals’ organism in the course of application after intoxication by an- ticholineterase substances.