Prolan and folliculin

Removal of the anterior pituitary gland by extirpation, an operation considered impossible for a long time due to the special anatomical position of this gland, along with disturbed growth and metabolism, leads to a number of profound changes in the sexual apparatus: heat ceases, atrophy of the sexual apparatus takes place and, as a secondary phenomenon, the sexual instinct weakens. The opposite is observed when a small piece of the pituitary gland is transplanted. If the pituitary gland is transplanted to a non-mature animal, rapid puberty ensues, the ovaries enlarge, the follicles mature, which burst, giving rise to the formation of yellow bodies, with all the secondary phenomena in the sexual apparatus: uterine hypertrophy, the phenomenon of uterine heat from the vagina, etc.