Potential Applications of Mesenchymal Stem Cells Derived From Autologous Microfragmented Adipose Tissue in the Treatment of Osteoarthritis



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Abstract

Regenerative medicine is gaining increasing recognition in osteoarthritis treatment. Articular cartilage regeneration is central to regenerative strategies for managing osteoarthritis. Several surgical techniques have been employed to restore joint cartilage; however, their clinical efficacy remains limited. Mesenchymal stem cells are a promising source for cartilage regeneration owing to their capacity to differentiate into chondrocytes and bone cells and ability to secrete trophic factors with regenerative properties. Adipose tissue-derived mesenchymal stem cells are easily harvested, particularly from subcutaneous fat depots. This study outlines the methods of obtaining autologous microfragmented adipose tissue containing the stromal vascular fraction enriched with mesenchymal stem cells and discusses associated advantages and limitations. Moreover, the study synthesizes available clinical data on the safety and efficacy of intra-articular administration of autologous microfragmented adipose tissue with stromal vascular fraction in patients with osteoarthritis. Further long-term randomized controlled trials are warranted to assess the therapeutic potential and safety of adipose-derived mesenchymal stem cells in osteoarthritis management.

About the authors

Vladimir A. Beloborodov

Irkutsk State Medical University

Email: BVA555@yandex.ru
ORCID iD: 0000-0002-3299-1924
SPIN-code: 5116-0931

MD, Dr. Sci. (Medicine), Professor, Head, Depart. of General Surgery

Russian Federation, Irkutsk

Ivan A. Stepanov

Irkutsk State Medical University; Kharlampiev Clinic

Author for correspondence.
Email: edmoilers@mail.ru
ORCID iD: 0000-0001-9039-9147
SPIN-code: 5485-6316

Assistant Lecturer, Depart. of General Surgery

Russian Federation, Irkutsk

Alexander V. Man'kov

Irkutsk State Medical University

Email: man-aleksandrv@yandex.ru
ORCID iD: 0000-0001-8701-6432
SPIN-code: 7135-2828

MD, Cand Sci. (Medicine), Assistant Professor, Head, Depart. of Anesthesiology-Reanimatology

Russian Federation, Irkutsk

Svetlana V. Sokolova

Irkutsk State Medical University

Email: soksv@bk.ru
ORCID iD: 0000-0003-1153-0683
SPIN-code: 2293-8820

MD, Cand Sci. (Medicine), Assistant Professor, Depart. of Faculty Surgery

Russian Federation, Irkutsk

Alexander P. Frolov

Irkutsk State Medical University

Email: frolovphd@mail.ru
ORCID iD: 0000-0002-3453-548X
SPIN-code: 4335-2400

MD, Cand Sci. (Medicine), Assistant Professor, Depart. of General Surgery

Russian Federation, Irkutsk

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