Kazan medical journalKazan medical journalКазанский медицинский журнал0368-48142587-9359Eco-Vector65344110.17816/KMJ653441YKELGCReviewsОбзорыReview ArticlePotential applications of mesenchymal stem cells derived from autologous microfragmented adipose tissue in the treatment of osteoarthritisВозможности применения мезенхимальных стволовых клеток, полученных из аутологичной микрофрагментированной жировой ткани, в лечении остеоартрозаhttps://orcid.org/0000-0002-3299-19245116-0931BeloborodovVladimir A.БелобородовВладимир Анатольевич
Russian Federation

MD, Dr. Sci. (Medicine), Professor, Head, Depart. of General Surgery

д-р мед. наук, профессор, заведующий, каф. общей хирургии

BVA555@yandex.ruhttps://orcid.org/0000-0001-9039-91475485-6316StepanovIvan A.СтепановИван Андреевич
Russian Federation

Assistant Lecturer, Depart. of General Surgery

ассистент, каф. общей хирургии

edmoilers@mail.ruhttps://orcid.org/0000-0001-8701-64327135-2828MankovAleksander V.МаньковАлександр Викторович
Russian Federation

MD, Cand Sci. (Medicine), Assistant Professor, Head, Depart. of Anesthesiology-Reanimatology

канд. мед. наук, доцент, заведующий, каф. анестезиологии-реаниматологии

man-aleksandrv@yandex.ruhttps://orcid.org/0000-0003-1153-06832293-8820SokolovaSvetlana V.СоколоваСветлана Викторовна
Russian Federation

MD, Cand Sci. (Medicine), Assistant Professor, Depart. of Faculty Surgery

канд. мед. наук, доцент, каф. факультетской хирургии и урологии

soksv@bk.ruhttps://orcid.org/0000-0002-3453-548X4335-2400FrolovAlexander P.ФроловАлександр Петрович
Russian Federation

MD, Cand Sci. (Medicine), Assistant Professor, Depart. of General Surgery

канд. мед. наук, доцент, каф. общей хирургии

frolovphd@mail.ruIrkutsk State Medical UniversityИркутский государственный медицинский университетKharlampiev ClinicХарлампиевская клиника210720250508202510646266340402202522052025Copyright ©; 2025, Eco-VectorCopyright ©; 2025, Эко-Вектор2025Eco-VectorЭко-Векторhttps://creativecommons.org/licenses/by-nc-nd/4.0/https://kazanmedjournal.ru/kazanmedj/article/view/653441

Regenerative medicine is gaining increasing recognition in osteoarthritis treatment. Articular cartilage regeneration is central to regenerative strategies for managing osteoarthritis. Several surgical techniques have been employed to restore joint cartilage; however, their clinical efficacy remains limited. Mesenchymal stem cells are a promising source for cartilage regeneration owing to their capacity to differentiate into chondrocytes and bone cells and ability to secrete trophic factors with regenerative properties. Adipose tissue-derived mesenchymal stem cells are easily harvested, particularly from subcutaneous fat depots. This study outlines the methods of obtaining autologous microfragmented adipose tissue containing the stromal vascular fraction enriched with mesenchymal stem cells and discusses associated advantages and limitations. Moreover, the study synthesizes available clinical data on the safety and efficacy of intra-articular administration of autologous microfragmented adipose tissue with stromal vascular fraction in patients with osteoarthritis. Further long-term randomized controlled trials are warranted to assess the therapeutic potential and safety of adipose-derived mesenchymal stem cells in osteoarthritis management.

В настоящее время регенеративная медицина набирает всё большую популярность в лечении пациентов с остеоартрозом. В основе регенеративного лечения остеоартрита лежит восстановление суставного хряща. Для регенерации суставного хряща применяются различные хирургические процедуры, имеющие ограниченную клиническую эффективность. Мезенхимальные стволовые клетки принято считать перспективным источником для регенерации суставного хряща из-за их способности дифференцироваться в хрящевые и костные клетки и секретировать трофические факторы с регенеративными функциями. Мезенхимальные стволовые клетки жировой ткани легко изолируются и особенно доступны из подкожной жировой клетчатки. В статье описаны способы получения аутологичной микрофрагментированной жировой ткани со стромально-васкулярной фракцией, содержащей мезенхимальные стволовые клетки, их преимущества и недостатки. Авторами работы предпринята попытка объединения результатов исследований, которые посвящены изучению клинической эффективности и безопасности применения аутологичной микрофрагментированной жировой ткани со стромально-васкулярной фракцией, содержащей мезенхимальные стволовые клетки, у пациентов с остеоартрозом. Необходимо проведение дальнейших долгосрочных рандомизированных контролируемых исследований с целью детального анализа эффективности и безопасности применения мезенхимальных стволовых клеток жировой ткани в лечении пациентов с остеоартрозом.

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