On the specificity of the tuberculin reaction

Abstract

The classic studies of R. Koch'a showed for the first time that an organism infected with tbc reacts in a completely different way to the introduction of tbc cultures and various cultures derived from them. drugs than a normal animal that has not yet had a chance to get acquainted with the tbc antigen. Koch's main experiments boil down to the following: if you inject a healthy guinea pig with a pure culture of tbc rods, then, as a rule, the wound at the site of the injection heals up and seems to heal in the first days: however, then, within 10-14 days, a solid a nodule that soon opens and forms a place ulcerating until the death of the animal; at the same time, swelling of the nearest lymph glands develops, and later the generalization of the process occurs.