Evaluation of hormonal balance indicators in men with arterial hypertension in various types of left ventricular remodeling

Aim. To evaluate features of the hormonal balance in men with hypertension with different types of left ventricular geometry.

Methods. The study included 63 men (mean age 49.74±4.91 years) with II degree hypertension (the disease duration 6.03±3.64 years). In all patients the level of testosterone, estradiol, prolactin, thyroid-stimulating hormone in blood serum were determined and echocardiography was performed, which was done on the expert class machine PHILIPS iE33 (Netherlands).

Results.. According to echocardiographic examination data concentric hypertrophy prevailed in the left ventricular hypertrophy structure - 33 (52.38%) patients, eccentric hypertrophy occured in 18 (28.57%), concentric remodeling - in 12 (19.04%) patients. When analyzing the hormonal profile of patients a significant difference in testosterone levels in patients with various types of the left ventricular remodeling was revealed. In the concentric left ventricular hypertrophy, testosterone levels were lowest, and in some patients were beyond the lower limit of the normal range. Estradiol level exceeded the reference range values in men with concentric type of hypertrophy. The estradiol content in the group of men with concentric left ventricular remodeling was significantly higher than in patients with eccentric hypertrophy (p

Conclusion. In patients with hypertension, concentric left ventricular hypertrophy (as compared with eccentric hypertrophy and concentric remodeling) occurs more often, it is accompanied by a decrease in total testosterone level in blood serum; timely correction of early androgen deficiency will allow to reduce the risk of cardiovascular complications.