The role of microRNAs in the development of gastric and duodenal ulcers

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Abstract

The research highlights the fundamental concepts of microRNA, the mechanisms of RNA interference, the importance of microRNA in the development of diseases. Combining the experience of domestic and foreign researchers, the authors identified the main miRNAs involved in the development of gastric and duodenal ulcers. The article also describes the main mechanisms of regulation of the inflammatory process in gastric and duodenal ulcers associated with Helicobacter pylori, the influence of microorganisms on the expression of various microRNA types and the control of the cellular immune response. In addition, the review presents the latest research on methods for diagnosing Helicobacter pylori-associated peptic ulcer based on the determination of circulating microRNAs. The results of an experimental model of treatment of patients infected with Helicobacter pylori with drugs that act on non-coding RNA are presented.

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About the authors

Yulia R. Sagadatova

Bashkir State Medical University

Author for correspondence.
Email: sagadatovay@mail.ru
ORCID iD: 0000-0002-2922-7087
SPIN-code: 2634-5987
ResearcherId: GXA-0228-2022

Postgrad. Stud., Depart. of Surgical Diseases

Russian Federation, Ufa, Russia

Anvar G. Khasanov

Bashkir State Medical University

Email: hasanovag@mail.ru
ORCID iD: 0000-0001-5870-8894
Scopus Author ID: 7006453675

M.D., D. Sci. (Med.), Prof., Head of Depart., Depart. of Surgical Diseases

Russian Federation, Ufa, Russia

Irina R. Gilyazova

Bashkir State Medical University; Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences

Email: gilyasova_irina@mail.ru
ORCID iD: 0000-0001-9499-5632

Cand. Sci. (Biol.), Assoc. Prof., Senior Research Fellow

Russian Federation, Ufa, Russia; Ufa, Russia

Damir I. Sufiyarov

Bashkir State Medical University

Email: kafsurg@bashgmu.ru
ORCID iD: 0000-0002-9898-6757

student

Russian Federation, Ufa, Russia

Ildar F. Sufiyarov

Bashkir State Medical University

Email: ildars74@mail.ru
ORCID iD: 0000-0001-8688-8458
Scopus Author ID: 23053114300

M.D., D. Sci. (Med.), Prof., Depart. of Surgical Diseases

Russian Federation, Ufa, Russia

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