Features of the population immunity to SARS-CoV-2 development in staff members of medical organizations during the spread of COVID-19

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Abstract

Background. The ongoing COVID-19 pandemic generates the urgent need of monitoring the herd immunity among healthcare workers as a high-risk group for infection.

Aim. Determining the level and structure of population immunity to SARS-CoV-2 in the medical workers during the second peak of COVID-19 from August to November 2020.

Material and methods. The study involved 15,158 medical workers from 91 medical organizations of the Republic of Tatarstan. The age of the examined stuff members varied from 18 to 74 years, the average age was 45.48±0.1016 years, most of them were women (13 627, 89.87±0.258%). Testing for the presence of total antibodies (immunoglobulin classes G, A and M) to SARS- CoV-2 was performed once by the enhanced chemiluminescence method. Statistical processing was carried out by methods of variation statistics and correlation analysis according to the Pearson method using MS Excel and WinPepi.

Results. Seroprevalence to SARS-CoV-2 in medical workers was 35.23±0.388%. An increase in seropositive individuals level from 27.44±0.265% in August to 57.91±0.499% in November and an increase in the average geometric mean titer of total antibodies (immunoglobulin classes A, M, G) from 84.43 in August to 101.09 in November 2020 were detected. The level of individuals with antibodies increased with age from 18 to 59 years and decreased in group of 60–70 years. The largest proportion of seropositive to SARS-CoV-2 individuals was found among junior (42.01±1.384%) and middle grade (37.5±0.527%) medical staff of hospitals for patients with COVID-19, ambulance and emergency stations. Among the seropositive to the SARS-CoV-2 workers the proportion of asymptomatic forms of infection was 84.97±0.498%. According to the level of seroprevalence, municipal districts of the Republic of Tatarstan were divided into three groups: moderate — 8.9–39.0; average — 42.9–49.6, high level — 53.1–64.4.

Сonclusion. An increase in seroprevalence to SARS-CoV-2 was revealed among medical workers of the Republic of Tatarstan from August to November 2020 during the second peak of COVID-19.

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About the authors

Marat N. Sadykov

Ministry of Health of the Republic of Tatаrstan

Email: Sadykov.Marat@tatar.ru
ORCID iD: 0000-0003-4890-1812

M.D., Cand. Sci. (Med.), Minister

Russian Federation, Kazan, Russia

Vasil B. Ziatdinov

Kazan Scientific Research Institute of Epidemiology and Microbiology

Email: kniem@mail.ru
ORCID iD: 0000-0001-8029-6515

M.D., Dr. Sci. (Med.), Director

Russian Federation, Kazan, Russia

Irina D. Reshetnikova

Kazan Scientific Research Institute of Epidemiology and Microbiology; Institute of Fundamental Medicine and Biology of Kazan Federal University

Author for correspondence.
Email: reshira@mail.ru
ORCID iD: 0000-0002-3584-6861

M.D., Cand. Sci. (Med.), Deputy Head, Kazan Scientific Research Institute of Epidemiology and Microbiology; Assoc. Prof.

Russian Federation, Kazan, Russia; Kazan, Russia

Niyaz M. Khakimov

Kazan State Medical University

Email: hakimniaz@gmail.com
ORCID iD: 0000-0001-7895-0012

M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Epidemiology and Evidence-Based Medicine

Russian Federation, Kazan, Russia

Dmitriy V. Lopushov

Kazan State Medical University; Kazan State Medical Academy — Brunch of the Russian Medical Academy of Postgraduate Education

Email: doctor225@mail.ru
ORCID iD: 0000-0001-8896-969X

M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Preventive Medicine and Human Ecology; Assoc. Prof., Depart. of Epidemiology and Disinfectology

Russian Federation, Kazan, Russia; Kazan, Russia

Guzel Sh. Isaeva

Kazan Scientific Research Institute of Epidemiology and Microbiology; Kazan State Medical University

Email: kniem@mail.ru
ORCID iD: 0000-0002-1462-8734

M.D., Dr. Sci. (Med.), Prof., Deputy Director for Innovative Development; Head, Depart. of Microbiology named after Academician V.M. Aristovsky

Russian Federation, Kazan, Russia; Kazan, Russia

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Supplementary files

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2. Рис. 1. Динамика уровней серопревалентности с августа по ноябрь 2020 г. среди работников медицинских организаций муниципальной собственности Республики Татарстан; по оси ординат — серопревалентность (%), по оси абсцисс — месяцы

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3. Рис. 2. Динамика среднегеометрического титра антител с августа по ноябрь 2020 г. среди серопозитивных работников медицинских организаций муниципальной собственности Республики Татарстан; по оси ординат — среднегеометрический титр антител, по оси абсцисс — месяцы

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4. Рис. 3. Корреляционная связь между серопревалентностью и напряжённостью иммунитета к SARS-CoV-2 у работников медицинских организаций муниципальной собственности Республики Татарстан (метод — по Пирсону); по оси ординат — среднегеометрический титр антител, по оси абсцисс — серопревалентность (%)

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5. Рис. 4. Серопревалентность к SARS-CoV-2 медицинских работников муниципальных районов Республики Татарстан с августа по ноябрь 2020 г.

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6. Рис. 5. Доля лиц с бессимптомными формами из общего числа серопозитивных к SARS-CoV-2 медицинских работников медицинских организаций Республики Татарстан в августе — ноябре 2020 г.; по оси ординат — доля лиц с бессимптомными формами от всех серопозитивных (%), по оси абсцисс — возраст (годы)

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