Features of the clinical course of nephrolithiasis in patients with hyperparathyroidism

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Abstract

Aim. To assess the incidence of kidney stone disease and to identify its clinical course in patients with primary hyperparathyroidism.

Methods. 48 medical records of patients hospitalized with primary hyperparathyroidism were retrospectively analyzed. The average age of the patients was 57 [53; 61] years. The medical history, complaints upon admission, the clinical presentation, the results of laboratory test and instrumental examination were studied in evaluating the medical records. The patients were divided into the group with nephrolithiasis (n=33) and the group without nephrolithiasis (n=15). The differences between the two groups were tested for statistical significance by the Mann–Whitney U test.

Results. Among patients with primary hyperparathyroidism, nephrolithiasis was detected in 69% of patients, of which 90% were women in the postmenopausal period. The course of the kidney stone disease in these patients was characterized by frequent recurrence with a predominance of bilateral renal impairment (62%). The duration of nephrolithiasis before the diagnosis of primary hyperparathyroidism was 6 [1; 19] years, and this complication was often the first manifestation of the disease. According to the instrumental examination of kidney in patients with nephrolithiasis, small stones up to 5 mm in diameter were detected in 42% of cases, asymptomatic kidney stones — in 15% of cases. A severe complication of primary hyperparathyroidism — staghorn calculi were found in 2 (10%) patients. The patients in the group with nephrolithiasis showed higher serum calcium (p=0.022) and parathyroid hormone (p=0.007) levels compared with patients in the group without nephrolithiasis.

Conclusion. Nephrolithiasis is a common complication of primary hyperparathyroidism; the presence of nephrolithiasis is associated with more significant changes in calcium and phosphate metabolism and is also characterized by a frequent asymptomatic course, thus requiring attention of specialists to this type of complications in primary hyperparathyroidism.

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I A Baranova

Northern State Medical University

Author for correspondence.
Email: baranov.av1985@mail.ru
Russian Federation, Arkhangelsk, Russia

T A Zykova

Northern State Medical University

Email: baranov.av1985@mail.ru
Russian Federation, Arkhangelsk, Russia

A V Baranov

Northern State Medical University; Cherepovets State University

Email: baranov.av1985@mail.ru
Russian Federation, Arkhangelsk, Russia; Cherepovets, Russia

References

  1. Nadeeva R.A., Kamasheva G.R., Amirov N.B. Hyperparathyroidism and urolithiasis: diagnostics errors (clinical case). The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 163–168. (In Russ.) doi: 10.20969/VSKM.2016.9(6).163-168.
  2. Imamverdiev S.B., Gusein-­zade R.T. Possible influence of epidemiological risk factors on the development of urolithiasis. Therapeutic Archive. 2016; 88 (3): 68–72. (In Russ.) doi: 10.17116/terarkh201688368-72.
  3. Agaronyan A.V., Satybaldyev V.M., Manuilov V.М. Medical-social component of urolithiasis development and treatment in northern navy servicemen. Ekologiya cheloveka. 2008; (11): 42–47. (In Russ.)
  4. Clinical guidelines. Urolithiasis disease. Russian Society of Urology. 2019; 73 p. https://pharm-spb.ru/docs/lit/Urologia_Rekomendazii%20po%20diagnostike%20i%20lecheniyu%20mochekamennoi%20bolezni%20(ROU,%202019).pdf (access date: 02.02.2021). (In Russ.)
  5. Dedov I.I., Melnichenko G.A., Mokrysheva N.G., Rozhinskaya L.Ya., Kusnezov N.S., Pigarova E.A., Voronkova I.A., Lipatenkova A.K., Egshatyan L.V., Mamedova E.O., Krupinova Yu.A. Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment. Problemy endocrinologii. 2016; 62 (6): 40–77. (In Russ.) doi: 10.14341/probl201662640-7.
  6. Rozhinskaya L.Ya., Rostomyan L.G., Mokrysheva N.G., Mirnaya S.S., Kirdyankina N.O. Epidemiology of primary hyperparathyroidism. Lechaschi Vrach. 2010; 11: 50–56. (In Russ.)
  7. Dedov I.I., Rozhinskaya L.Ya., Mokrysheva N.G., Vasileva T.O. Etiology, pathogenesis, clinical presentation, diagnostics and treatment of the primary hyperparathyroi­dism. Osteoporoz i osteopatii. 2010; 13 (1): 13–18. (In Russ.) doi: 10.14341/osteo2010113-18.
  8. Peretokina E.V., Mokrysheva N.G. Nephrolithiasis in primary hyperparathyroidism: a contemporary look. Ozhirenie i metabolizm. 2014; (3): 3–8. (In Russ.). doi: 10.14341/OMET201433-8.
  9. Verdelli С., Corbetta S. Kidney involvement in patients with primary hyperparathyroidism: an update on clinical and molecular aspects. Eur. J. Endocrinol. 2017; 176: R39–R52. doi: 10.1530/EJE-16-0430.
  10. Rozhinskaya L.Ya., Rostomyan L.G., Mokrysheva N.G., Mirnaya S.S., Kirdjankina N.O. Epidemiologic aspects of primary hyperparathyroidism in Russia. Osteoporoz i osteopatii. 2010; (3): 13–18. (In Russ.)
  11. Borretta G., Gianotti L., Cesario F., Borretta V., Tassone F. Renal function in primary hyperparathyroi­dism. G. Ital. Nefrol. 2010; 27 (Suppl. 50): S91–S95. PMID: 20922703.
  12. Bilezikian J.P., Brandi M.L., Eastell R., Shonni J., Silverberg S.J., Udelsman R., Marcocci C., Potts Jr.J.T. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. J. Clin. Endocrinol. Metab. 2014; 99 (10): 3561–3569. doi: 10.1210/jc.2014-1413.
  13. Baranova I.A., Zykova T.A., Sergeeva O.A. Comparative analysis of clinical manifestations of primary hyperparathyroidism by results of hospitalizations and screening for hypercalcia in the Arkhangelsk region. Medical Herald of the South of Russia. 2019; 10 (4): 36–42. (In Russ.) doi: 10.21886/2219-8075-2019-10-4-36-42.
  14. Dedov I.I., Mokrysheva N.G., Mirnaia S.S., Rostomian L.G., Pigarova E.A., Rozhinskaia L.I. Epidemiology of primary hyperparathyroidism in Russia (the first results from the database of Federal state institution “Endocrinological Research Centre”). Problemy endocrinologii. 2011; 57 (3): 3–10. (In Russ.) doi: 10.14341/probl20115733-10.
  15. Suh J.M., Cronan J.J., Monchik J.M. Primary hyperparathyroidism: Is there an increased prevalence of renal stone disease. Am. J. Roentgenol. 2008; 191 (3): 908–911. doi: 10.2214/AJR.07.3160.
  16. Cipriani C., Biamonte F., Costa A.G., Zhang C., Biondi P., Diacinti D., Pepe J., Piemonte S., Scillitani A., Minisola S., Bilezikian J.P. Prevalence of kidney stones and vertebral fractures in primary hyperparathyroidism ­using imaging technology. J. Clin. Endocrinol. Metab. 2015; 100 (4): 1309–1315. doi: 10.1210/jc.2014-3708.

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2. Рис. 1. Размер почечных конкрементов у пациентов с нефролитиазом на фоне первичного гиперпаратиреоза по данным визуализирующих методов исследования (n=21); D — диаметр

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