Risk factors for developing epilepsy in children with cerebral pals

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Abstract

Aim. To identify the most important risk factors affecting the development of epilepsy in children with cerebral palsy.

Methods. The study included 160 cerebral palsy patients with and without epilepsy who received treatment at the Baku Children's Neurological Hospital. The patients were divided into 2 groups. The first group consisted of 110 (68.7%) patients with cerebral palsy and epilepsy, and the second group consisted of 50 (31.3%) patients with cerebral palsy. The age of children ranged from 1 to 14 years. Statistical data processing was performed by using the SPSS software version 16.0. The Chi-square test was used to compare categorical measurements. T-test for independent groups was used for comparison between groups of continuous measurements. Binary logistic regression was used for determining the risk factors. In all tests, the level of statistical significance was set at p <0.05.

Results. There was no significant difference in age and gender distribution between groups (p=0.492 and p=0.818, respectively). 10 (9.1%) children in the main group had a positive family history of epilepsy (odds ratio 8.08, p=0.028). Neonatal seizures were observed in 25 (22.7%) children in the main group and 3 (6%) children in the control group (odds ratio 4.4, p=0.010). The presence of infection during pregnancy in the mother was found in both the main (39.1%) and control (20%) groups (odds ratio 2.6, p=0.018). Level IV of the Gross Motor Function Classification System (GMFCS) was the most frequent among patients with epilepsy (odds ratio 12.8; p=0.035). The incidence rate of epilepsy among cerebral palsy patients was 68.7%. The mean age of onset of seizures was 19.2±26.6 months. The most frequent epileptic seizures (55.5%) occurred in spastic quadriplegic cerebral palsy.

Conclusion. The presence of a positive family history of epilepsy, neonatal seizures, maternal infection during pregnancy and severe GMFCS level were identified as factors for the development of epilepsy in patients with cerebral palsy; premature birth, presence of hypoxic-ischemic injury, low birth weight, consanguineous marriage, multiple pregnancies, or gender were not identified as risk factors for the development of epilepsy in children.

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About the authors

A K Mammadbayli

Azerbaijan Medical University

Email: vagabova_medina@yahoo.com
Russian Federation, Baku, Azerbaijan

M R Taghiyeva

Azerbaijan Medical University

Author for correspondence.
Email: vagabova_medina@yahoo.com
Russian Federation, Baku, Azerbaijan

References

  1. Rosenbaum P., Paneth N., Leviton A., Goldstein M., Bax M., Damiano D., Dan B., Jacobsson B. A report: the definition and classification of cerebral palsy April 2006. Eur. J. Paediatr. Neurol. Suppl. 2007; 109: 8–14.
  2. Sellier E., Uldall P., Calado E., Sigurdardottir S., Torrioli M.G., Platt M.J., Cans C. Epilepsy and cerebral palsy: characteristics and trends in children born in 1976–1998. Eur. J. Paediatr. Neurol. 2012; 16 (1): 48–55. doi: 10.1016/j.ejpn.2011.10.003.
  3. Carlsson M., Hagberg G., Olsson I. Clinical and aetiological aspects of epilepsy in children with cerebral palsy. Dev. Med. Child Neurol. 2003; 45 (6): 371–376. doi: 10.1017/s0012162203000719.
  4. Gururaj A.K., Sztriha L., Bener A., Dawodu A., ­Eapen V. Epilepsy in children with cerebral palsy. Seizure. 2003; 12 (2): 110–114. doi: 10.1016/s1059131102002558.
  5. Kulak W., Sobaniec W. Risk factors and prognosis of epilepsy in children with cerebral palsy in North-Eas­tern Poland. Brain and Development. 2003; 25 (7): 499–506. doi: 10.1016/s0387-7604(03)00040-8.
  6. Karatoprak E., Sözen G., Saltık S. Risk factors associated with epilepsy development in children with cerebral palsy. Child’s Nervous System. 2019; 35 (7): 1181–1187. doi: 10.1007/s00381-019-04152-w.
  7. Mert G.G., Incecik F., Altunbasak S., Herguner O., Mert M.K., Kiris N., Unal I. Factors affecting epilepsy development and epilepsy prognosis in cerebral palsy. Pediatr. Neurol. 2011; 45: 89–94. doi: 10.1016/j.pediatrneurol.2011.03.001.
  8. Zelnik N., Konopnicki M., Bennett-Back O., Castel-Deutsch T., Tirosh E. Risk factors for epilepsy in children with cerebral palsy. Eur. J. Paediatr. Neurol. 2010; 14: 67–72. doi: 10.1016/j.ejpn.2009.06.002.
  9. Palisano R.J., Cameron D., Resenbaum P.L., Walter S.D., Rusell D. Stability of the gross motor function classification system. Dev. Med. Child Neurol. 2006; 48: 424–428. doi: 10.1111/j.1469-8749.2006.tb01290.x.
  10. Scheffer I.E., Berkovic S., Meletti S., Connolly M.B., French J., Guilhoto L., Hirsch E., Jain S., Mathern G.W., Moshé S.L., Nordli D.R., Perucca E., Tomson T., Wiebe S., Zhang Y.H., Zuberi S.M. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017; 58: 512–521. doi: 10.1111/epi.13709.
  11. Cans C., Guillem P., Baille F., Arnaud C., Chalmers J., Cussen G., McManus V., Parkes J., Dolk H., Hagberg G., Hagberg B., Hensey O., Dowding V., Jarvis S., Colver A., Johnson A., Surmann G., Krägeloh-Mann I., Michaelis R., Pharoah P., Platt M.J., Topp M., Udall P., Torrioli M., Miceli M., Wichers M., van Nieuwenhuizen O. Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Surveillance of cerebral palsy in Europe (SCPE). Dev. Med. Child Neurol. 2000; 42: 816–824. doi: 10.1017/S0012162200001511.
  12. Sadowska M., Sarecka-Hujar B., Kopyta I. Evaluation of risk factors for epilepsy in pediatric patients with cerebral palsy. Brain Sci. 2020; 10: 481. doi: 10.3390/brainsci10080481.
  13. Persson M., Razaz N., Tedroff K., Joseph K.S., Cnattingius S. Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: Population based cohort study in Sweden. BMJ. 2018; 360: k207. doi: 10.1136/bmj.k207.
  14. Wu C.S., Pedersen L.H., Miller J.E., Sun Y., Streja E., Uldall P., Olsen J. Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy. PLoS One. 2013; 8 (2): e57552. doi: 10.1371/journal.pone.0057552.
  15. Schneider R.E., Ng P., Zhang X., Andersen J., Buckley D., Fehlings D., Kirton A., Wood E., van Rensburg E., Shevell M.I., Oskoui M. The association between maternal age and cerebral palsy risk factors. Pediatr. Neurol. 2018; 82: 25–28. doi: 10.1016/j.pediatrneurol.2018.01.005.
  16. Aksu F. Nature and prognosis of seizures in patients with cerebral palsy. Dev. Med. Child Neurol. 1990; 32: 661–668. doi: 10.1111/j.1469-8749.1990.tb08426.x.
  17. Shehata G.A., El-Tallawy H.N., Farghaly W.M., Badary R., Rageh T.A. Epileptic and cognitive changes in children with cerebral palsy: An Egyptian study. Neuropsychiatr. Dis. Treat. 2014; 10: 971. doi: 10.2147/NDT.S59600.

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2. Рис. 1. Распределение уровней поражения больших моторных функций пациентов согласно шкале Gross Motor Function Classification System (GMFCS) по группам; ЦП — церебральный паралич

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© 2021 Mammadbayli A.K., Taghiyeva M.R.

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