Comparative analysis of the treatment results of patients with breast cancer using various ­reconstruction methods

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Background. Breast cancer in many cases becomes the main cause of deterioration in the quality of life of patients due to the presence of severe postoperative asymmetry.Аim. To compare immediate and long-term results, quality of life indicators and cost-effectiveness in the treatment of patients diagnosed with breast cancer using an endoprosthesis and lipofilling reconstruction.

Material and methods. A prospective study of the treatment results of 72 patients diagnosed with breast cancer was carried out. Patients in the control group (n=40) underwent subcutaneous mastectomy with endoprosthesis plastics. Patients of the main group (n=32) underwent subcutaneous mastectomy with primary reconstruction by lipofilling. The calculation of indicators characterizing the efficiency of the use of hospital beds of a medical institution was carried out, the number of cases and days of temporary disability was calculated, an analysis of economic costs was made based on the tariff for a completed case of treatment of the disease. All statistical analyzes were performed using the Statistica 10.0 software. The study established a significance test of p <0.05.

Results. In the compared groups, the immediate results of surgical treatment did not differ statistically significantly (p=0.973), while the quality of life in patients after subcutaneous mastectomy with plastic lipofilling was significantly higher on the social functioning scale (0.004) than after reconstruction with the use of an endoprosthesis. When using the method of reconstruction with the use of lipofilling, it was possible to statistically significantly reduce the length of stay of patients in the hospital.

Conclusion. The use of lipofilling as a new method of reconstruction in patients diagnosed with breast cancer allows maintaining significantly high quality of life indicators on the scale of social functioning in comparison with the group of patients who underwent reconstruction with an endoprosthesis, and also makes it possible to significantly reduce the economic costs of treating patients.

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About the authors

Oleg I. Kaganov

Samara Regional Clinical Oncology Dispensary; Samara State Medical University

ORCID iD: 0000-0003-1765-6965

M.D., D. Sci. (Med.), Assoc. Prof., Deputy Chief Physician for Research

Russian Federation, Samara, Russia; Samara, Russia

Nikita A. Orlov

Samara State Medical University

ORCID iD: 0000-0002-0406-6803


Russian Federation, Samara, Russia

Maksim V. Tkachev

Samara Regional Clinical Oncology Dispensary; Samara State Medical University

Author for correspondence.
ORCID iD: 0000-0002-4183-0647

M.D., Cand. Sci. (Med.), Oncologist, Oncology Depart. (General Oncology); Assistant, Depart. of Oncology

Russian Federation, Samara, Russia; Samara, Russia


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Supplementary files

Supplementary Files
1. Рис. 1. Дооперационная разметка у пациентки основной группы

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2. Рис. 2. Вид больной контрольной группы через 1 мес ­после операции

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3. Рис. 3. Пациентка основной группы через 1 мес после операции

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4. Рис. 4. Безрецидивная выживаемость в группах сравнения

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5. Рис. 5. Общая выживаемость в группах сравнения

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