A complex approach to the chronic recurrent cystitis treatment

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Abstract

Background. Chronic cystitis is the dominating urinary tract disease. Due to its high prevalence among women, this issue remains topical in medicine.

Aim. To evaluate the effectiveness of the sodium hyaluronate in the complex treatment of chronic recurrent cystitis.

Material and methods. The research included 60 patients with a confirmed clinical diagnosis of “chronic recurrent cystitis” in the clinic of Kazan State Medical University for the period from July 2020 to July 2021. To evaluate the effectiveness of treatment, the patients were divided into groups using the copy-pair method. The first (main) group included 30 women receiving anti-inflammatory therapy and local treatment with collargol instillations. After that, the patients were prescribed the topical use of sodium hyaluronate: 40 mg (50 ml) once a week for 1 month. The second (control) group also included 30 patients who received only anti-inflammatory therapy and local treatment with collargol. The average age of the observed patients was 30.5±1.5 years: in the first group — 31.1±1.5 years, in the second group — 31.9±1.3 years. All patients underwent control cystoscopy, ultrasound and urodynamic examinations on the 15th and 30th day of treatment. The Welch's t-test, Fisher's test, analysis of variance with repeated observations were used as statistical data analysis methods.

Results. Treatment was completed by all patients in both groups. The patients’ management showed a significant decrease in the number of urination (up to 6 times a day), and urgent uriesthesia was recorded in 86.6% of women in the main group compared to 60% in the control group (p <0.05). The control cystoscopy performed on the planned 15th day of treatment showed positive dynamics in the bladder mucosa recovery under the collargol influence. All patients of the first group had no changes in the mucous membrane of the bladder. There was a positive dynamics of urodynamic parameters in the first group compared to the control group.

Conclusion. The sodium hyaluronate, which was included in the complex therapy of chronic recurrent cystitis, accelerates the process of the bladder mucosa regeneration after local treatment with collargol and reduces the time of its recovery.

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About the authors

Dinara R. Sayapova

Kazan State Medical University

Author for correspondence.
Email: Sayapova.69@mail.ru
ORCID iD: 0000-0003-3221-7872

M.D., Cand. Med. Sci., Assistant, Department of Urology named after E.N. Sitdykov

Russian Federation, Kazan, Russia

Alexey Yu. Zubkov

Kazan State Medical University

Email: dr.alexz@icloud.com
ORCID iD: 0000-0002-1727-8995

M.D., Cand. Med. Sci., Associate Professor, Department of Urology named after E.N. Sitdykov

Russian Federation, Kazan, Russia

Timur M. Ibragimov

Kazan State Medical University

Email: Ibragimov.20024@mail.ru
ORCID iD: 0000-0003-1122-0132

M.D., student

Russian Federation, Kazan, Russia

References

  1. Gyaurgiev TA, Kuzmenko AV, Vachtel VM, Lukyanovich PA. Treatment of patients with chronic recurrent bacterial cystitis in the acute stage in combination with phototherapy using the apparatus “Svetozar”. Sistemnyy analiz i upravlenie biome­ditsinskikh sistemakh. 2014;13(4):821–824. (In Russ.)
  2. Glybochko PV, Alya­ev YuG, Gadzhieva ZG, Lokshin KL, Mirkin YaB. The use of hyaluronic acid in the treatment of chronic cystitis. Effektivnaya farmakoterapiya. 2011;(45):8–11. (In Russ.)
  3. Faxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Dis Mon. 2003;9(1):53–70. doi: 10.1067/mda.2003.7.
  4. Sinyakova LA. Contemporary views on antibiotic therapy of the urinary tract. Management tactics for patients with recurrent cystitis. Klinicheskaya immunologiya. Allergolo­giya. Infektologiya. 2010;(1 S):79–82. (In Russ.)
  5. Neimark BA. Treatment of persistent dysuria in females. Urologiya. 2003;(3):16–20. (In Russ.)
  6. Abrams P, Cardozo J, Fall M. The stadartisation of terminology of lower urinary tract function. Neurourol and Urodyn. 2002;21;167–168. doi: 10.1002/nau.10052.
  7. Gadzhieva ZhK. Narusheniya mocheispuskaniya. (Urination disorders.) YuG Alyaev, editor. Moscow: ­GEOTAR-Media; 2010. 176 р. (In Russ.)
  8. Alyaev YuG, Glybochko PV, Pushkar’ DYu. Urologiya. Rossiyskie klinicheskie rekomendatsii. (Urology. Russian clinical guidelines.) Moscow: Medforum-Al’fa; 2018. 544 p. (In Russ.)
  9. Bonkat G, Bartolett R, Bruyère F, Cai T, Geerlings SE, Köves B, Schubert S, Wagenlehner F. Guidelines Associates: T Mezei, A Pilatz, B Pradere, R Veerattera­pillay. European Association of Urology (EAU). Guidelines on urological infections. EAU-2019. https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Urological-infections-2019.pdf (access date: 14.07.2021).
  10. Urologiya. Rossiy­skie klinicheskie rekomendatsii. (Urology. Russian clinical guidelines.) YuG Alyaev, PV Glybochko, DY Pushkar’, editors. Moscow: GEOTAR-Media; 2015. 480 р. (In Russ.)
  11. Neimark AI, Neimark BA, Sopotov AV. Сorrection of microcirculation disturbances in patients with chronic cystitis by using peloidotherapy. Modern problems of science and education. 2015;(5):139. (In Russ.)
  12. Slesarevskaya MN, Kuzmin IV, Zarkih AV, Shabudina NO. Assessment of microcirculation’s condition of the bladder wall at women with chronic recurrent cystitis. Urologicheskie vedomosti. 2012;(2):26–31. (In Russ.)
  13. Pereverzev AS, Kogan MI. Infektsii i vospalenie v urologii. (Infection and inflammation in urology.) Moscow: ABV-press; 2007. 224 р. (In Russ.)
  14. Sorokin DA, Sevryukov FA, Malinina OYu, Zorin DG. Hyaluronic acid (URO-HYAL) after transurethral endoscopic surgical management of benign prostatic hyperplasia. Effektivnaya farmakoterapiya. 2014;(2):20–24. (In Russ.)
  15. Sayapova DR, Zubkov AYu. Combination therapy in the integrated treatment of recurrent chronic cystitis. Kazan Medical Journal. 2021;101(4);603–608. (In Russ.) doi: 10.17816/KMJ2020-603.

Supplementary files

Supplementary Files
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1. Рис. 1. Количество мочеиспусканий по данным дневников мочеиспусканий

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2. Рис. 2. Количество ургентных позывов по данным дневников мочеиспускания

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