Influence of insomnia and emotional disorders on the development of cognitive impairment in patients with chronic brain ischemia and arterial hypertension

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Abstract

Aim. To study correlation between sleep disorders, cognitive impairment and emotional state in patients suffering from chronic brain ischemia and artreial hypertension.

Methods. The study included 65 patients of Kazan City clinical hospital №7: 35 males and 30 females aged 21 to 92. Self-Administered Gerocognitive Exam test, Spielberg-Hanin scale, questionnaire developed by the authors, Pittsburgh sleep quality assessment were used.

Results. It was shown that reduced sleep quality in patients with chronic brain ischemia is associated with worsening cognitive impairment. Among responders with poor subjective sleep quality only 21% had cognitive function within normal limits, while in 88% of patients with good subjective sleep quality cognitive function was normal. High level of anxiety was found to cause poor sleep quality. 57% of patients were diagnosed with high level of situational anxiety combined with poor subjective sleep quality and among patients with good sleep quality in only 12% of responders high level of situational anxiety was found. In patients increase of the level of anxiety is associated with more frequent cognitive impairment. Only 38% of patients with high level of anxiety had normal cognitive function compared to 85% of responders with low level of anxiety and normal function.

Conclusion. Sleep quality and level of anxiety influence the development of cognitive disorders in patients with chronic brain ischemia.

About the authors

E Z Yakupov

Kazan State Medical University

Author for correspondence.
Email: ed_yakupov@mail.ru
Kazan, Russia

T S Grigor’eva

Kazan State Medical University

Email: ed_yakupov@mail.ru
Kazan, Russia

References

  1. Brainin М., Tuomilehto J., Heiss W.-D. et al. Post-stroke cognitive decline: An update and perspectives for clinical research. Eur. J. Neurol. 2015; 22 (2): 229-238. doi: 10.1111/ene.12626.
  2. Захаров В.В. Когнитивные нарушения в неврологической практике. Трудный пациент. 2005; (5): 4-9.
  3. Ковров Г.В., Палатов С.Ю., Лебедев М.А., Мачулина А.И. Инсомния и когнитивные нарушения. Эффективн. фармакотерап. Неврология. 2014; (3). http://umedp.ru/articles/insomniya_i_kognitivnye_narusheniya.html (дата обращения: 08.07.2016).
  4. Psaltopoupou T., Sergentsnis T.N., Panagiotakos D.B. et al. Mediterranean diet, stroke, cognitive impairment, and depression: a meta-analysis. Ann. Neurol. 2013; 74 (4): 580-590. doi: 10.1002/ana.23944.
  5. Scarmeas N., Luchsinger J.A., Schupf N. et al. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009; 302 (6): 627-637. doi: 10.1001/jama.2009.1144.
  6. Sherzai A., Heim L.Y., Boothby C. et al. Stroke, food group, and dietary patterns: a systematic review. Nutr. Rev. 2012; 70 (8): 423-435. doi: 10.1111/j.1753-4887.2012.00490.x.
  7. Sofi F., Macchi C., Abbate R. et al. Effectiveness of the Mediterranean diet: can it help delay or prevent Alzheimer’s disease? J. Alzheimer Dis. 2010; 20 (3): 795-801. doi: 10.3233/JAD-2010-1418.
  8. Solfrizzi V., Frisardi V., Seripa D. et al. Mediterranean diet in predementia and dementia syndromes. Curr. Alzheimer Res. 2011; 8 (5): 520-542. doi: 10.2174/156720511796391809.
  9. Полуэктов М.Г., Преображенская И.С. Нарушения сна и когнитивных функций, подходы к терапии. Неврология, нейропсихиатрия, психосоматика. 2014; (1): 68-73. doi: 10.14412/2074-2711-2014-1-68-73.
  10. Chang W.P., Liu M.E., Chang W.C. et al. Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan. PLoS One. 2013; 8 (10): e78655. http://dx.doi.org/10.1371/journal.pone.0078655 (access date: 30.06.2016).
  11. Jelicic M., Bosma H., Ponds R.W. et al. Subjective sleep problems in later life as predictors of cognitive decline. Report from the Maastricht Ageing Study (MAAS). Int. J. Geriatr. Psychiatry. 2002; 17 (1): 73-77. doi: 10.1002/gps.529.
  12. Negergaard M. Neuroscience. Garbage truck of the brain. Science. 2013; 340 (6140): 1529-1530. doi: 10.1126/science.1240514.
  13. Xie L., Kang H., Chen M.J. et al. Sleep drives metabolite clearance from the adult brain. Science. 2013; 342 (6156): 373. doi: 10.1126/science.1241224.
  14. Якупов Э.З., Александрова Е.А., Трошина Ю.В. и др. Нарушения сна как междисциплинарная проблема. Ж. международной мед. 2014; 4 (9): 125-131.
  15. Якупов Э.З. Нарушения сна как междисциплинарная проблема. Ж. международной мед. 2014; 4 (9): 75-78.
  16. Ковров Г.В., Вейн А.М. Стресс и сон у человека. М.: Нейро-медиа. 2004; 61.
  17. Преображенская И.С. Когнитивные нарушения и расстройства сна. Эффективн. фармакотерап. Неврология. 2015; (3). http://umedp.ru/articles/kognitivnye_narusheniya_i_rasstroystva_sna.html (дата обращения: 15.07.2016).
  18. Филатова Е.Г., Наприенко М.В. Терапия нарушений памяти и внимания у молодых пациентов. Неврология, нейропсихиатрия, психосоматика. 2013; (3): 18-23. doi: 10.14412/2074-2711-2013-2334.
  19. Boustani M., Peterson B., Hanson L. et al; U.S. Preventive SERVICES TASK Force: Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force. Ann. Intern. Med. 2003; 138 (11): 927-937. doi: 10.7326/0003-4819-138-11-200306030-00015.
  20. Scharre D.W., Chang S.-I., Murden R.A. et al. Community cognitive screening using the Self-Administered Gerocognitive Examination (SAGE). J. Neuropsychiatr. Clin. Neurosci. 2014; 26 (4): 369-375. doi: 10.1176/appi.neuropsych.13060145.
  21. Scharre D.W. SAGE: A test to detect signs of Alzheimer’s and dementia. The Ohio State University Wexner Medical Center. 2014. https://wexnermedical.osu.edu/brain-spine-neuro/memory-disorders/sage (access date: 27.06.2016).
  22. Морозов А.В. Деловая психология. Учебное пособие для вузов. СПб.: СОЮЗ. 1999; 112-115.
  23. Полуэктов М.Г. Клинический алгоритм диагностического и лечебного выбора при инсомнии. Эффективн. фармакотерап. Неврология и психиатрия. 2013; (12): 22-28.

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