Parathyroid Carcinoma: Diagnosis and Treatment
- Authors: Matyanin M.V.1, Zhdankina N.V.2, Zubeev P.S.1
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Affiliations:
- City Hospital № 33 of the Leninsky District of Nizhny Novgorod
- Lobachevsky State University of Nizhny Novgorod
- Section: Clinical observations
- Submitted: 13.03.2025
- Accepted: 18.04.2025
- Published: 30.06.2025
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/677128
- DOI: https://doi.org/10.17816/KMJ677128
- EDN: https://elibrary.ru/HZMVFN
- ID: 677128
Cite item
Abstract
This paper describes the diagnostic search, treatment, and follow-up of a patient with parathyroid carcinoma. The authors analyzed the clinical signs and results of the investigations. Despite the long-term clinical presentation of urolithiasis, parathyroid hyperfunction was not suspected. Hyperparathyroidism was detected only when damage to the musculoskeletal system became clinical. The differential diagnoses included parathyroid carcinoma, iliac osteosarcoma, and anterior mediastinal tumor. The main difficulty in the verification of the diagnosis in this case was the atypical localization of the affected parathyroid gland. Conventional imaging is not effective in detecting this location of parathyroid carcinoma. Parathyroidectomy allowed for the final diagnosis of parathyroid carcinoma. Follow-up of the case after surgery revealed improvement, including less pain, improvement in parathyroid hormone and calcium levels, restoration of the iliac cortex, and reossification of the brown tumor. In general, this patient exhibited signs suggestive of parathyroid carcinoma, including very high parathyroid hormone and calcium levels, simultaneous renal and bone involvement, and a large mediastinal mass together with high corrected calcium levels. However, because the disease is rare and the tumor had an atypical localization, the diagnostic search for the tumor was long. The authors highlight the importance of early detection and a multidisciplinary approach for improving the prognosis of patients with this rare condition.
About the authors
Maxim V. Matyanin
City Hospital № 33 of the Leninsky District of Nizhny Novgorod
Email: matyanin@list.ru
ORCID iD: 0009-0001-5640-7702
SPIN-code: 5958-5280
MD, Cand. Sci. (Medicine), Surgeon, Depart. of Surgery № 1
Russian Federation, Nizhny NovgorodNatalya V. Zhdankina
Lobachevsky State University of Nizhny Novgorod
Author for correspondence.
Email: zhdankina@unn.ru
ORCID iD: 0000-0003-1109-3268
SPIN-code: 1730-0095
MD, Cand. Sci. (Medicine), Assistant Professor, Depart. of Internal Diseases
Russian Federation, Nizhny NovgorodPavel S. Zubeev
City Hospital № 33 of the Leninsky District of Nizhny Novgorod
Email: mlpu33@mail.ru
ORCID iD: 0000-0003-0414-9104
SPIN-code: 7091-8394
MD, Dr. Sci. (Medicine), Chief Medical Officer
Russian Federation, Nizhny NovgorodReferences
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