Plasma fibronectin in patients with chronic active hepatitis and cirrhosis of the liver with signs of disseminated intravascular blood coagulation syndrome

The plasma fibronectin level is determined in 39 patients with chronic active hepatitis and in 90 patients with cirrhosis of the liver by solid phase immunoenzyme method. All the patients with hepatitis and cirrhosis with signs of disseminated intravascular blood coagulability syndrome manifest a decrease of the fibronectin level, more pronounced in hypocoagulative phase of disseminated intravascular blood coagulability syndrome as a result of the consumption coagulopathy. A sharp decrease of the fibronection level (below 40% that of the norm) may suggest the possible prolongation of disseminated intravescular blood coagulability syndrome, the feasibility of the development of reticuloendothelial system block.