Gastroesophageal reflux disease in residents of the Trans-Baikal Territory

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Abstract

Aim. To study the prevalence of gastroesophageal reflux disease (GERD) symptoms and lesions of the esophageal mucosa in residents of Zabaikalsky krai, taking into account ethnicity.

Methods. The first stage: 371 residents of Zabaikalsky krai over 18 years old, were door-to-door interviewed by using the GERD questionnaire (GerdQ). The respondents with 8 or more points were classified as having GERD symptoms. Additionally, we collected passport data, smoking status, alcohol and coffee consumption, anthropometric data and social status. The second stage: we analyzed 2130 upper gastrointestinal (GI) endoscopy reports from Regional Clinical Hospital in Chita.

Results. 48 (12.9%) of 371 respondents had GERD symptoms. 135 (36.4%) respondents were Buryats, and 236 (63.6%) were non-Buryats, with the latter more often had GerdQ total score of 8 or more [38 (16.1%) non-­Buryats and 10 (7.4%) Buryats, p=0.009]. The average age of non-Buryats respondents with GERD symptoms was 53.4±17.47 years and exceeded that in the group without symptoms (46.2±19.2 years), p=0.035. The age of Buryats with and without GERD symptoms did not differ (42.67±11.52 and 37.89±15.54 years, respectively, р=0.087). The prevalence of obesity, smoking, alcohol and coffee consumption of respondents with and without GERD symptoms, both among Buryats and non-Buryats was the same. Of the 2130 patients who underwent endoscopy, 164 (7.8%) had morphological changes in the esophagus, 105 (4.9%) had erosive esophagitis (EE). Catarrhal and erosive chan­ges in the esophagus were detected in 156 non-Buryats (91 men and 66 women) (7.7%), while EE was diagnosed in 97 (4.8%) patients. 6.5% (5 women and 3 men) Buryats had the esophagus pathology, which caused by erosion. It was found that in non-Buryats group EE develop more often in male respondents (p=0.0019). Only non-Buryats had catarrhal changes in the esophagus (37.8%, 59 people), p=0.0312. At the same time, the incidence of complica­ted disease course in groups with EE was the same (p=0.8934).

Conclusion. About 13% of residents of Zabaikalsky krai have weekly symptoms of GERD, male of a non-Buryat ethnic group are more likely to develop erosive esophagitis than women; the incidence of complications of esophagitis is the same in Buryats and non-Buryats respondents groups.

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About the authors

A A Zhilina

Chita State Medical Academy

Author for correspondence.
Email: albina1228@yandex.ru
Russian Federation, Chita, Russia

N V Lareva

Chita State Medical Academy

Email: albina1228@yandex.ru
Russian Federation, Chita, Russia

E V Luzina

Chita State Medical Academy

Email: albina1228@yandex.ru
Russian Federation, Chita, Russia

References

  1. Belya­evа Yu.N. Diseases of the digestive system as a medical and social problem. Bulletin of Medical Internet Conferences. 2013; 3 (3): 566–568. (In Russ.)
  2. Starostin B.D. Gastroesophageal reflux disease (Part I). Epidemiology, risk factors. Gastroenterology of St. Petersburg. 2014; (1–2): 2–14. (In Russ.)
  3. Lyamina S.V., Maev I.V., Kalish S.V. et al. Features of the functional activity of macrophage link of immunity with gastroesopha­geal reflux disease depending on the type of reluctate: in vitro model. Terapevticheskiy arkhiv. 2018; (2): 19–23. (In Russ.) doi: 10.26442/terarkh201890219-23.
  4. Lazebnik L.B., Masharova A.A., Bordin D.S. et al. Results of a multicenter trial “Epidemiology of gastroesophageal reflux disease in Russia” (MEGRE). Terapevticheskiy arkhiv. 2011; (1): 45–50. (In Russ.)
  5. Isakov V.A., Morozov S.V., Stavraki E.S., Komarov R.M. Heartburn pre­valence analysis: a national epidemiological study of adult urban populations. Eksperimental'naia i klinicheskaia gastroenterologiia. 2008; (1): 20–30. (In Russ.)
  6. Tsukanov V.V., Khomenko O.V., Rzhavicheva O.S. et al. Prevalence of Helicobacter pylori and GERD in Mongo­loids and Caucasians of Eastern Siberia. Russian medical journal of gastroenterology and hepatology of coloprocto­logy. 2009; (3): 38–41. (In Russ.)
  7. Butorin N.N., Rzhavicheva O.S., Homenko O.V. Prevalence and risk factors of heartburn in organized population of administrative centre of Khakasia republic. Russian journal of gastroenterology of hepatology coloproctology. 2010; (2): 39–43. (In Russ.)
  8. Mayev I.V., Samsonov A.A., Andreyev N.G. Symptom Of Heartburn: Habitual Discomfort Or A Serious Problem? Farmateka. 2011; (10): 18–25. (In Russ.)
  9. Kaybysheva V.O., Kuche­ryavy Yu.A., Trukhmanov A.S. et al. Results of multicenter observation study on application of international questionnaire GerdQ for diagnosticsof gastroesophageal reflux disease. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2013; (5): 15–23. (In Russ.)
  10. Savarino E., Marabotto E., Bodini G. et al. Review article: prevalence and epidemiology of gastro-oesophageal reflux disease in Japan. Aliment. Pharmacol. Ther. 2004; 20 (8): 5–8. doi: 10.1111/j.1365-2036.2004.02220.x.
  11. Nam K., Shin J.E., Kim S.E. et al. Prevalence and risk factors for upper gastrointestinal diseases in health check-up subjects: a nationwide multicenter study in Korea. Scand. J. Gastroenterol. 2018; 53 (8): 910–916. doi: 10.1080/00365521.2018.1487992.
  12. Zagari R.M., Eusebi L.H., Rabitti S. et al. Prevalence of upper gastrointestinal endoscopic findings in the community: A systematic review of studies in unselected samples of subjects. J. Gastroenterol. Hepatol. 2016; 31 (9): 1527–1538. doi: 10.1111/jgh.13308.
  13. Vasilevskiy D.I., Skurihin S.S., Luft A.V. et al. Prevalence of erosive esophagitis and peptic esophageal strictures. Khirurgiya. Zhurnal im. N.I. Pirogova. 2015; (6): 35–37. (In Russ.) doi: 10.17116/hirurgia2015635-37.
  14. Dent J., Vakil N., Jones R. Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study. Gut. 2010; 59 (6): 714–721. doi: 10.1136/gut.2009.200063.
  15. Lazebnik L.B., Masharova A.A., Bordin D.S. et al. Results of a multicenter trial “Epidemiology of Gastroesopha­geal Reflux Disease in Russia” (MEGRE). Terapevticheskiy ­arkhiv. 2011; (1): 45–50. (In Russ.)
  16. Reshetnikov O.V., Kurilovich S.A., Bobak M. et al. Gastrointestinal symptoms in adult population of Novosibirsk city: prevalence and risk factors. Terapevticheskiy arkhiv. 2009; (2): 11–16. (In Russ.)
  17. Abdulkhakov S.R., Abdulkhakov R.A. Prevalence of symptoms of gastroesophageal reflux disease in Kazan. Practical medicine. 2011; (1): 82–85. (In Russ.)
  18. Kinoshita Y., Adachi K., Hongo M., Haruma K. Systematic review of the epidemiology of gastroesopha­geal reflux disease in Japan. J. Gastroenterol. 2011; 46 (9): 1092–1103. doi: 10.1007/s00535-011-0429-3.
  19. Kolesnikova L.I., Darenskaya M.A., Pervushina O.A Ethnic difference of health disorders in indigenous ethnic group of Baikal region (literature review). Acta Biomedica Scientifica. 2013; (4): 160–165. (In Russ.)
  20. Gunji T., Sato H., Iijima K. et al. Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males. J. Gastroenterol. 2011; 46: 448–455. doi: 10.1007/s00535-010-0359-5.
  21. Kim N., Lee S.W., Cho S.I. et al. H. pylori and Gerd Study Group of Korean College of Helicobacter and Upper Gastrointestinal Research. College of Helicobacter and Upper Gastrointestinal Research. The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux di­sease: a nationwide multicentre prospective study in Korea. Alimentary Pharmacol. Therap. 2008; 27: 173–185. doi: 10.1111/j.1365-2036.2007.03561.x.
  22. Huerta-Iga F., Bielsa-Fernández M.V., Remes-­Troche J.M. et al. Diagnosis and treatment of gastroeso­phageal reflux disease: recommendations of the Asociación Mexicana de Gastroenterología. Revista de Gastroente­rología de Méxi­co. 2016; 81 (4). 208–222. doi: 10.1016/j.rgmx.2016.04.003.
  23. Loffeld R.J., Liberov B., Dekkers P.E. The changing prevalence of upper gastrointestinal endoscopic diagnoses: a single-centre study. Neth. J. Med. 2012; 70 (5): 222–226.
  24. Ko S.-H., Baeg M.K., Jung H.S. et akl. Russian Caucasians have a higher risk of erosive reflux disease compared with East Asians: A direct endoscopic comparison. Neurogastroenterologi & Motilty. 2017; 29 (5): е13002. DOI: 10,1111/nmo.13002.
  25. Kim B.J., Cheon W.S., Oh H.C. et al. Prevalence and risk factor of erosive esophagitis observed in Korean National Cancer Screening Program. J. Korean Med. Sci. 2011; 26 (5): 642–646. doi: 10.3346/jkms.2011.26.5.642.
  26. Ou J.L., Tu C.C., Hsu P.I. et al. Prevalence and risk factors of erosive esophagitis in Taiwan. J. Chin. Med. Assoc. 2012; 75 (2). 60–64. doi: 10.1016/j.jcma.2011.12.008.
  27. Wang K., Zhang L., He Z.H. et al. A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in ­China. Chin. Med. J. (Engl.). 2019; 5.132 (13): 1516–1523. doi: 10.1097/CM9.0000000000000275.
  28. Abraham A., Lipka S., Hajar R. et al. Erosive esopha­gitis in the obese: The effect of ethnicity and gender on its association. Gastroenterol. Res. Pract. 2016; article ID 7897390: 7. doi: 10.1155/2016/7897390.
  29. Piqué N., Ponce M., Garrigues V. et al. Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross-sectional study). https://www.researchgate.net/publication/282223898_Prevalence_of_severe_esophagitis_in_Spain_Results_of_the_PRESS_study_Prevalence_and_Risk_factors_for_Esophagitis_in_Spain_A_cross-sectional_study (access date: 15.02.2020).
  30. Alkaddour A., McGaw C., Hritani R. et al. African American ethnicity is not associated with development of Barrett's oesophagus after erosive oesophagitis. Dig. Liver Dis. 2015; 47 (10): 853–856. doi: 10.1016/j.dld.2015.06.007.

Supplementary files

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1. Рис. 1. Диаграмма размаха возраста (годы) бурят и респондентов, не относящихся к бурятскому этносу, имеющих эндоскопические признаки поражения пищевода (р=0,0147)

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