Pathophysiological disturbances in complicated pancreatic pseudocysts

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Abstract

Aim. To determine profibrogenic mediators, markers of endothelial dysfunction and hemostasis in patients with different types of complicated pancreatic pseudocysts.

Methods. The study included 47 patients aged 43.58±7.38 years: 42 males and 5 females. The patients were allocated to three groups based on the classification of pancreatic pseudocysts by A. D’Egidio and М. Schein (1991). All patients underwent surgery. Serum levels of vascular endothelial growth factor, matrix metalloproteinase-9, matrix metalloproteinase-2 tissue inhibitor, the complex of metalloproteinase-9 and inhibitor, plasma levels of interleukin-6, -8, -18 and -10 were determined by ELISA method. Blood glutathione peroxidase activity and malondialdehyde serum level were determined by spectrophotometry.

Results.Levels of Interleukin-6, -8 and -18 was higher in patients with type I of pseudocysts compared to control (p

Conclusion. Increased concentration of matrix metalloproteinase-2 tissue inhibitor and increased inhibition coefficient in patients with chronic pancreatitis may reflect favorable conditions for pancreatic remodeling and fibrosis.

About the authors

O Yu Gerbali

Medical academy named after S.I. Georgievskiy of the Federal State Autonomous Educational Institution of Higher Education «Crimean Federal University named after V.I. Vernadskiy», Simferopol, Russia

Author for correspondence.
Email: oksana.gerbali@mail.ru

I A Krivoruchko

Kharkiv National Medical University, Kharkiv, Ukraine

Email: oksana.gerbali@mail.ru

N N Goncharova

Kharkiv National Medical University, Kharkiv, Ukraine

Email: oksana.gerbali@mail.ru

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© 2015 Gerbali O.Y., Krivoruchko I.A., Goncharova N.N.

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