Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study


Дәйексөз келтіру

Толық мәтін

Аннотация

Background:Vitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.

Objective:The objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, the factors, and possible complications associated with it.

Methods:All patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.

Results:Hypovitaminosis D was common, with 83.7% of the patients showing levels below 30ng/dl and 55.4% below 20ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.

Conclusion:Overall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIVrelated complications like PCP or wasting syndrome.

Авторлар туралы

Theodoros Androutsakos

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

Marianna Politou

Hematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens

Email: info@benthamscience.net

Sofia Boti

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens

Email: info@benthamscience.net

Theodoros Pittaras

Hematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens

Email: info@benthamscience.net

Athanasios Kontos

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens

Email: info@benthamscience.net

Theodore Kordossis

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens

Email: info@benthamscience.net

Abraham Pouliakis

Second Department of Pathology, Medical School, National and Kapodistrian University of Athens

Email: info@benthamscience.net

George Panayiotakopoulos

Department of Pharmacology, Medical School, University of Patras

Email: info@benthamscience.net

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