Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study
- 作者: Androutsakos T.1, Politou M.2, Boti S.1, Pittaras T.2, Kontos A.1, Kordossis T.1, Pouliakis A.3, Panayiotakopoulos G.4
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隶属关系:
- Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens
- Hematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens
- Second Department of Pathology, Medical School, National and Kapodistrian University of Athens
- Department of Pharmacology, Medical School, University of Patras
- 期: 卷 22, 编号 4 (2024)
- 页面: 240-248
- 栏目: Medicine
- URL: https://kazanmedjournal.ru/1570-162X/article/view/644110
- DOI: https://doi.org/10.2174/011570162X302844240605104855
- ID: 644110
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详细
Background:Vitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.
Objective:The objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, the factors, and possible complications associated with it.
Methods:All patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.
Results:Hypovitaminosis D was common, with 83.7% of the patients showing levels below 30ng/dl and 55.4% below 20ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.
Conclusion:Overall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIVrelated complications like PCP or wasting syndrome.
作者简介
Theodoros Androutsakos
Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens
编辑信件的主要联系方式.
Email: info@benthamscience.net
Marianna Politou
Hematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens
Email: info@benthamscience.net
Sofia Boti
Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens
Email: info@benthamscience.net
Theodoros Pittaras
Hematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens
Email: info@benthamscience.net
Athanasios Kontos
Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens
Email: info@benthamscience.net
Theodore Kordossis
Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens
Email: info@benthamscience.net
Abraham Pouliakis
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens
Email: info@benthamscience.net
George Panayiotakopoulos
Department of Pharmacology, Medical School, University of Patras
Email: info@benthamscience.net
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