Synthesis and structure of 4-(het)aryl-6-methyl-2-cyanoimino-N,N-diethyl-1,2,3,4-tetrahydropyrimidine-5-carboxamides

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Resumo

A series of previously unknown 4-(het)aryl-6-methyl-2-cyanoimino-N,N-diethyl-1,2,3,4-tetrahydropyrimidine-5-carboxamides was synthesized by the reaction of N,N-diethyl-3-oxobutanamide with (het)arylaldehydes and N-cyanoguanidine. The structure of the obtained compounds was established by IR, 1H NMR spectroscopy and single crystal X-ray diffraction analysis.

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Sobre autores

N. Buzmakova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Autor responsável pela correspondência
Email: tanyapgfa@yandex.ru
ORCID ID: 0000-0003-3171-0438
Rússia, Perm

T. Zamaraeva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
ORCID ID: 0000-0002-9932-9628
Rússia, Perm

N. Slepova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
ORCID ID: 0000-0003-3924-3715
Rússia, Perm

F. Sobin

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
ORCID ID: 0000-0002-8416-6934
Rússia, Perm

M. Dmitriev

Пермский государственный национальный исследовательский университет

Email: tanyapgfa@yandex.ru
ORCID ID: 0000-0002-8817-0543
Rússia, Пермь

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2. Scheme 1.

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3. Fig.1. General view of the molecule of compound 1 in a crystal, represented by thermal ellipsoids with 50% probability.

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4. Fig.2. General view of the crystal packing of compound 1 (view along the 0a axis).

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